Retinoic acid administration and vitamin A status modulate retinoid X receptor   and retinoic acid receptor   levels in mouse brown adipose tissue

2004 ◽  
Vol 266 (1/2) ◽  
pp. 25-30 ◽  
Author(s):  
Joan Ribot ◽  
Francisco Felipe ◽  
M. Luisa Bonet ◽  
Andreu Palou
Keyword(s):  
Adipose Tissue ◽  
Retinoic Acid ◽  
Vitamin A ◽  
Brown Adipose Tissue ◽  
Retinoic Acid Receptor ◽  
Retinoid X Receptor ◽  
Acid Receptor ◽  
Vitamin A Status ◽  
Brown Adipose ◽  
Acid Administration

scholarly journals Effects of Vitamin-A Status on Hamster Tracheal Epithellum in Viva in Vitro

1989 ◽  
Vol 11 (3) ◽  
pp. 1-6 ◽  
Author(s):  
Luigi M. De Luca ◽  
Elizabeth M. McDowell
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Retinoic Acid Receptor ◽  
Normal Liver ◽  
Acid Receptor ◽  
New Horizons ◽  
Vitamin A Status ◽  
Essential Nutrient ◽  
Hepatoma Tissue

In this paper we have suggested the new concept of exotrophic cells, i.e. cells that have conditionally escaped the need for an essential nutrient, such as vitamin A. These exotrophs might become fixed by a mutation and eventually contribute to the tumorigenic phenotype. The discovery of the retinoic acid receptor (RAR) has opened up new horizons in the search for the mechanism of action of retinoic acid [17; 18]. It is intriguing that a second retinoic acid receptor, RARE, is abundantly expressed in hepatoma tissue and not in normal liver; Benbrook et al. [191 suggest that the erroneous expression of the RARE might contribute to tumour development in liver. How and whether these findings relate to the vitamin-A-deficient status of hepatoma cells remains to be understood.

scholarly journals Both retinoic-acid-receptor- and retinoid-X-receptor-dependent signalling pathways mediate the induction of the brown-adipose-tissue-uncoupling-protein-1 gene by retinoids

1999 ◽  
Vol 345 (1) ◽  
pp. 91-97 ◽  
Author(s):  
Rosa ALVAREZ ◽  
MaLuz CHECA ◽  
Sonia BRUN ◽  
Octavi VI±AS ◽  
Teresa MAMPEL ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Retinoic Acid ◽  
Brown Adipose Tissue ◽  
Uncoupling Protein ◽  
Retinoid X Receptor ◽  
Expression Vectors ◽  
Brown Adipocyte ◽  
Signalling Pathways ◽  
Uncoupling Protein 1 ◽  
Brown Adipose

The intracellular pathways and receptors mediating the effects of retinoic acid (RA) on the brown-fat-uncoupling-protein-1 gene (ucp-1) have been analysed. RA activates transcription of ucp-1 and the RA receptor (RAR) is known to be involved in this effect. However, co-transfection of an expression vector for retinoid-X receptor (RXR) increases the action of 9-cis RA but not the effects of all-trans RA on the ucp-1 promoter in brown adipocytes. Either RAR-specific {p-[(E)-2-(5,6,7,8,-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid} or RXR-specific [isopropyl-(E,E)-(R,S)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate, or methoprene] synthetic compounds increase the expression of UCP-1 mRNA and the activity of chloramphenicol acetyltransferase expression vectors driven by the ucp-1 promoter. The RXR-mediated action of 9-cis RA requires the upstream enhancer region at -2469/-2318 in ucp-1. During brown-adipocyte differentiation RXRα and RXRγ mRNA expression is induced in parallel with UCP-1 mRNA, whereas the mRNA for the three RAR subtypes, α, β and γ, decreases. Co-transfection of murine expression vectors for the different RAR and RXR subtypes indicates that RARα and RARβ as well as RXRα are the major retinoid-receptor subtypes capable of mediating the responsiveness of ucp-1 to retinoids. It is concluded that the effects of retinoids on ucp-1 transcription involve both RAR- and RXR-dependent signalling pathways. The responsiveness of brown adipose tissue to retinoids in vivo relies on a complex combination of the capacity of RAR and RXR subtypes to mediate ucp-1 induction and their distinct expression in the differentiated brown adipocyte.

Variations in parametrial white adipose tissue mass during the mouse estrous cycle: relationship with the expression of peroxisome proliferator-activated receptor-γ and retinoic acid receptor-α

2006 ◽  
Vol 84 (8-9) ◽  
pp. 887-892 ◽  
Author(s):  
Yaoting Gui ◽  
Zhiming Cai ◽  
Josef V. Silha ◽  
Liam J. Murphy
Keyword(s):  
Adipose Tissue ◽  
Retinoic Acid ◽  
Estrous Cycle ◽  
Retinoic Acid Receptor ◽  
Peroxisome Proliferator ◽  
Adipose Tissues ◽  
Peroxisome Proliferator Activated Receptor ◽  
Acid Receptor ◽  
Brown Adipose ◽  
Significant Difference

Estrogen and progestin participate in the regulation of adipose tissue metabolism, and peroxisome proliferator-activated receptor-gamma (PPARγ) and retinoic acid receptor-alpha (RXRα) are absolutely required for adipose tissue development. The present study is to investigate the changes in parametrial fat mass and expression of PPARγ and RXRα during estrous cycle in mice. Parametrial white adipose tissues (WAT), inter-scapula brown adipose tissues, and uteri from female mice were weighed. Blood samples were collected for the measurement of 17 β-estradiol and progesterone levels. An RNase protection assay and Western blot analysis were used to compare the expression of PPARγ and RXRα in adipose tissue. The mass of parametrial WAT in diestrus was significantly higher compared with estrus. However, there is no significant difference on the mass of brown adipose tissues during estrous cycle. The expression of PPARγ in WAT in diestrus was significantly higher than that in estrus. The expression of RXRα during estrous cycle was unchanged in both white and brown adipose tissues. In conclusion, the variation in parametrial WAT mass during the mouse estrous cycle correlates with changes in the expression of PPARγ in WAT.

scholarly journals Opposite effects of feeding a vitamin A-deficient diet and retinoic acid treatment on brown adipose tissue uncoupling protein 1 (UCP1), UCP2 and leptin expression

2000 ◽  
Vol 166 (3) ◽  
pp. 511-517 ◽  
Author(s):  
ML Bonet ◽  
J Oliver ◽  
C Pico ◽  
F Felipe ◽  
J Ribot ◽  
...  
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Retinoic Acid ◽  
Vitamin A ◽  
Brown Adipose Tissue ◽  
Mrna Expression ◽  
Uncoupling Protein ◽  
Uncoupling Protein 1 ◽  
Deficient Diet ◽  
Brown Adipose

The relationship between interscapular brown adipose tissue (IBAT) thermogenic potential and vitamin A status was investigated by studying the effects of feeding a vitamin A-deficient diet and all-trans retinoic acid (tRA) treatment on body weight and IBAT parameters in mice. Feeding a vitamin A-deficient diet tended to trigger opposite effects to those of tRA treatment, namely increased body weight, IBAT weight, adiposity and leptin mRNA expression, and reduced IBAT thermogenic potential in terms of uncoupling protein 1 (UCP1) mRNA and UCP2 mRNA expression. The results emphasize the importance of retinoids as physiological regulators of brown adipose tissue.

Ligand-inducible retinoid X receptor-mediated protein: DNA interactions in the retinoic acid receptor β2 gene promoter in vivo

1998 ◽  
Vol 136 (2) ◽  
pp. 109-118 ◽  
Author(s):  
Masato Ikeda ◽  
Remco A Spanjaard ◽  
Elizabeth W Noordhoek ◽  
Akio Kawaguchi ◽  
Toshimasa Onaya ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Gene Promoter ◽  
Retinoid X Receptor ◽  
Dna Interactions ◽  
Acid Receptor ◽  
Protein Dna Interactions ◽  
Retinoic Acid Receptor Β2

scholarly journals Vitamin A Status and Deposition in Neonatal and Weanling Rats Reared by Mothers Consuming Normal and High-Fat Diets with Adequate or Supplemented Vitamin A

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1460 ◽  
Author(s):  
Yanqi Zhang ◽  
Kristi M. Crowe-White ◽  
Lingyan Kong ◽  
Libo Tan
Keyword(s):  
Adipose Tissue ◽  
Vitamin A ◽  
Maternal Obesity ◽  
Sprague Dawley ◽  
High Fat ◽  
Vitamin A Status ◽  
Brown Adipose ◽  
Weanling Rats ◽  
Storage Organs ◽  
Fat Diets

The circulating level of vitamin A (VA; retinol) was reported to be lower in obese adults. It is unknown if maternal obesity influences the VA status of offspring. The objective of the study was to determine the VA status and deposition of neonatal and weanling rats reared by mothers consuming a normal or high-fat diet (NFD or HFD) with or without supplemented VA. Pregnant Sprague-Dawley rats were randomized to an NFD or HFD with 2.6 mg/kg VA. Upon delivery, half of the rat mothers in the NFD or HFD cohort were switched to an NFD or HFD with supplemented VA at 129 mg/kg (NFD+VA and HFD+VA group). The other half remained on their original diet (NFD and HFD group). At postnatal day 14 (P14), P25, and P35, pups (n = 4 or 3/group/time) were euthanized. The total retinol concentration in the serum, liver, visceral white adipose tissue (WAT), and brown adipose tissue (BAT) was measured. At P14, the HFD+VA group showed a significantly lower serum VA than the NFD+VA group. At P25, both the VA concentration and total mass in the liver, WAT, and BAT were significantly higher in the HFD+VA than the NFD+VA group. At P35, the HFD group exhibited a significantly higher VA concentration and mass in the liver and BAT compared with the NFD group. In conclusion, maternal HFD consumption resulted in more VA accumulation in storage organs in neonatal and/or weanling rats, which potentially compromised the availability of VA in circulation, especially under the VA-supplemented condition.

scholarly journals Retinoic acid receptor α and retinoid-X receptor-specific agonists synergistically target telomerase expression and induce tumor cell death

Oncogene ◽  
2003 ◽  
Vol 22 (57) ◽  
pp. 9142-9150 ◽  
Author(s):  
Frédéric Pendino ◽  
Charles Dudognon ◽  
Francois Delhommeau ◽  
Tewfik Sahraoui ◽  
Maria Flexor ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinoic Acid ◽  
Tumor Cell ◽  
Retinoic Acid Receptor ◽  
Retinoid X Receptor ◽  
Tumor Cell Death ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Α
Sign in / Sign up

Export Citation Format

Share Document