Umbilical Serum Insulin-like growth Factor 1 (IGF-1) in Newborns: Effects of Gestational Age, Postnatal Age, and Nutrition

2003 ◽  
Vol 73 (5) ◽  
pp. 343-346 ◽  
Author(s):  
Büyükkayhan ◽  
Tanzer ◽  
Erselcan ◽  
Çinar ◽  
Yönem
Keyword(s):  
Birth Weight ◽  
Growth Factor ◽  
Gestational Age ◽  
Serum Insulin ◽  
Study Group ◽  
Human Breast Milk ◽  
Insulin Like Growth Factor ◽  
Serum Samples ◽  
Labor Ward ◽  
The Relationship

Aim: The aim of this study was to determine the relationship between nutrition, gestational age, and birth weight, and serum insulin-like growth factor 1 (IGF-1) levels in newborns. Method: The first study group consisted of sixty newborns; thirty were fed with human breast milk and the others were fed with infant formula. Serum samples were obtained from all the newborns on days one and seven of life. Seventy-two pregnant women and their neonatal cord blood serum samples were obtained in a labor ward in the study group. All the serum samples were analyzed for IGF-1 by immunoassay. Result: Newborns fed with human milk had higher serum IGF-1 concentrations compared to formula-fed controls (p < 0.05). Cord IGF-1 levels showed a negative correlation with birthweight (p < 0.05) and a positive correlation with gestational age (p < 0.05). Conclusion: These findings suggest that IGF-1 levels during the neonatal period are influenced by gestational age, birth weight, and nutrition.

scholarly journals Longitudinal analysis of the relationship between serum insulin-like growth factor-I and radiographic knee osteoarthritis

1998 ◽  
Vol 6 (5) ◽  
pp. 362-367 ◽  
Author(s):  
Liana Fraenkel ◽  
Yuqing Zhang ◽  
Stephen B. Trippel ◽  
Timothy E. McAlindon ◽  
Michael P. LaValley ◽  
...  
Keyword(s):  
Growth Factor ◽  
Knee Osteoarthritis ◽  
Longitudinal Analysis ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
The Relationship ◽  
Radiographic Knee Osteoarthritis

scholarly journals The Relationship between Serum Insulin-Like Growth Factor I Levels and Ischemic Stroke Risk

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94845 ◽  
Author(s):  
Xiang Dong ◽  
Geng Chang ◽  
Xiao-Fei Ji ◽  
Ding-Bo Tao ◽  
Ying-Xin Wang
Keyword(s):  
Ischemic Stroke ◽  
Growth Factor ◽  
Stroke Risk ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Ischemic Stroke Risk ◽  
Growth Factor I ◽  
The Relationship

scholarly journals Serum Insulin-like Growth Factors and Insulin-like Growth Factor-binding Proteins: Clinical Implications

1999 ◽  
Vol 45 (8) ◽  
pp. 1384-1390 ◽  
Author(s):  
Clifford J Rosen
Keyword(s):  
Growth Factor ◽  
Binding Proteins ◽  
Serum Insulin ◽  
Cell Activity ◽  
Insulin Like Growth Factor ◽  
Disease States ◽  
Regulatory Systems ◽  
Igf I ◽  
The Relationship

Abstract The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated, and subcellular signaling mechanisms have been clarified. Clearly, both tissue and circulating growth factor concentrations are important in defining the relationship between IGF-I and cell activity. Bone, liver, and circulatory IGF-I have received the most attention by investigators, in part because of the ease of measurement and the interaction with disease states such as osteoporosis. More recently, attention has focused on the role IGF-I plays in neoplastic transformation and growth. Two large prospective observational studies have demonstrated greater risk for prostate and breast cancer associated with high circulating concentrations of IGF-I. Animal models and in vitro studies confirm that there is a close, albeit complex, interaction between IGF-I signaling and bone turnover. This report will focus on: (a) IGF physiology, including IGF ligands, binding proteins, and proteases; (b) the relationship between IGF-I and bone mass in respect to risk for osteoporosis; (c) the heritable regulation of the IGF-I phenotype; and (d) the association between serum IGF-I and cancer risk. The IGFs remain a major area for basic and clinical investigations; future studies may define both diagnostic and therapeutic roles for these peptides or their related proteins in several disease states.

Impact of Decreased Serum Insulin-Like Growth Factor-1 Levels on Central Aortic Compliance in Small-for-Gestational-Age Infants

Neonatology ◽  
2016 ◽  
Vol 111 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Yohei Akazawa ◽  
Motoko Kamiya ◽  
Shoko Yamazaki ◽  
Yoichiro Kawasaki ◽  
Chizuko Nakamura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Aortic Compliance
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