Depression is the most common form of mental illness and the major cause of disability
worldwide. Symptoms of depression, including feelings of intense sadness and hopelessness, may occur
after a specific event or in response to a gradual decline in health and functional status, often associated
with aging. Current therapies for treating these symptoms include antidepressant drugs, counseling
and behavioral therapy. However, antidepressant drugs are associated with mild to severe adverse
effects, which has prompted the need for better treatment options. Medicinal mushrooms are valuable
sources of food and medicine and are increasingly being used as supplements or as alternative medicines
in standard healthcare. Numerous studies have provided insights into the neuroprotective effects
of medicinal mushrooms, which are attributed to their antioxidant, anti-neuroinflammatory, cholinesterase
inhibitory and neuroprotective properties. In this review, we comprehensively examine the role
of these medicinal mushrooms in the treatment of depression. However, to apply these natural products
in clinical settings, the therapeutic agent needs to be properly evaluated, including the active ingredients,
the presence of synergistic effects, efficient extraction methods, and stabilization of the active ingredients
for delivery into the body as well as crossing the blood-brain barrier.
DEPRESI DAN TERAPI KOGNITIF-PERILAKU PADA WANITA PENDERITA HIV/AIDS YANG TERINFEKSI DARI SUAMINYA