Positive growth and development: From distress to coping across the life-span

2010 ◽  
Author(s):  
Erica Frydenberg ◽  
Krys Kaniasty ◽  
Erica Frydenberg ◽  
Barbara Jones ◽  
Esther Greenglass ◽  
...  
Parasitology ◽  
1982 ◽  
Vol 84 (2) ◽  
pp. 333-350 ◽  
Author(s):  
Marilyn E. Scott ◽  
M. E. Rau ◽  
J. D. McLaughlin

SUMMARYExperimental infections of mallards (Anas platyrhynchos L.) with Typhlocoelum cucumerinum sisowi (Skrjabin, 1913) and of canvasbacks (Aythya valisineria (Wilson)) with Typhlocoelum cucumerinum cucumerinum (Rudolphi, 1809) revealed significant differences in various parameters of the life-cycle in the definitive host. Both T. c. sisowi and T. c. cucumerinum migrate to the trachea via the abdominal cavity, air sacs and lungs, although T. c. cucumerinum migrate more quickly and more synchronously than T. c. sisowi. Typhlocoelum c. sisowi has a shorter expected life-span than T. c. cucumerinum but grows and reaches maturity more quickly than T. c. cucumerinum. Evidence suggests that T. c. cucumerinum has a higher fecundity than T. c. sisowi. These differences in the patterns of migration, growth and development are related not only to differences between the two host species but also to differences intrinsic to the parasites, and serve to provide biological support for considering them as separate sub-species.


Blood ◽  
2000 ◽  
Vol 95 (8) ◽  
pp. 2514-2522 ◽  
Author(s):  
Laurence A. Harker ◽  
Lorin K. Roskos ◽  
Ulla M. Marzec ◽  
Richard A. Carter ◽  
Judith K. Cherry ◽  
...  

The effects of thrombopoietic stimulation on megakaryocytopoiesis, platelet production, and platelet viability and function were examined in normal volunteers randomized to receive single bolus subcutaneous injections of 3 μg/kg pegylated recombinant megakaryocyte growth and development factor (PEG-rHuMGDF) or placebo in a 3:1 ratio. PEG-rHuMGDF transiently doubled circulating platelet counts, from 237 ± 41 × 103/μL to 522 ± 90 × 103/μL (P< .0001), peaking on day 12. Baseline and day-12 samples showed no differences in responsiveness of platelets to adenosine diphosphate or thrombin receptor agonist peptide (P > .4 in all cases); expression of platelet ligand-induced binding sites or annexin V binding sites (P > .6 in both cases); or density of platelet TPO-receptors (P > .5). Platelet counts normalized by day 28. The life span of autologous 111In-labeled platelets increased from 205 ± 18 hours (baseline) to 226 ± 22 hours (P < .01) on day 8. Platelet life span decreased from 226 ± 22 hours (day 8) to 178 ± 53 hours (P < .05) on day 18. The theoretical basis for senescent changes in mean platelet life span was illustrated by biomathematical modeling. Platelet turnover increased from 43.9 ± 11.9 × 103 platelets/μL/d (baseline) to 101 ± 27.6 × 103 platelets/μL/d (P = .0009), and marrow megakaryocyte mass expanded from 37.4 ± 18.5 fL/kg to 62 ± 17 × 1010 fL/kg (P = .015). Although PEG-rHuMGDF initially increased megakaryocyte volume and ploidy, subsequently ploidy showed a transient reciprocal decrease when the platelet counts exceeded placebo values. In healthy human volunteers PEG-rHuMGDF transiently increases megakaryocytopoiesis 2-fold. Additionally, peripheral platelets expand correspondingly and exhibit normal function and viability during the ensuing 10 days. The induced perturbation in steady state thrombopoiesis resolves by 4 weeks.


2000 ◽  
Vol 2 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Elizabeth J. Corwin

Cytokines are small signaling proteins released from a variety of cells that influence virtually every aspect of growth and development and every host response to infection, injury, and inflammation. Because of their widespread and potent effects across the life span, cytokines without a doubt influence nursing research and practice. From physiological and adaptive effects of cytokines to cytokine-induced diseases, nurses and nursing care are involved. Part II of this review highlights a few of the many examples of cytokines functioning in response to infection and inflammation, during the processes of reproduction, and in a variety of pathophysiological states. Implications for nursing research and practice are emphasized.


The Prostate ◽  
2012 ◽  
Vol 73 (4) ◽  
pp. 363-375 ◽  
Author(s):  
Arunangshu Das ◽  
James D. Bortner ◽  
Cesar A. Aliaga ◽  
Aaron Baker ◽  
Anne Stanley ◽  
...  

2010 ◽  
Vol 57 (4) ◽  
Author(s):  
Huiqing Chen ◽  
Yijia Li ◽  
Keping Chen ◽  
Qin Yao ◽  
Guohui Li ◽  
...  

Calorie restriction (CR) is known to extend life span from yeast to mammals. To gain an insight into the effects of CR on growth and development of the silkworm Bombyx mori at protein level, we employed comparative proteomic approach to investigate proteomic differences of hemolymph and fat body of the silkworm larvae subjected to CR. Thirty-nine differentially expressed proteins were identified by MALDI TOF/TOF MS. Among them, 19 were from the hemolymph and 20 from the fat body. The hemolymph of the CR group contained two down-regulated and 17 up-regulated proteins, whereas the fat body contained 15 down-regulated and five up-regulated ones. These proteins belonged to those functioning in immune system, in signal transduction and apoptosis, in regulation of growth and development, and in energy metabolism. Our results suggest that CR can alter the expression of proteins related to the above four aspects, implying that these proteins may regulate life span of the silkworm through CR.


2021 ◽  
Author(s):  
Norman Chivasa

One of the basic theories commonly believed in the secular world today is that conflict is inevitable which means that individuals and groups have needs, interests, dislikes, likes, partnerships, values and preferences which are often not compatible. This is also true of faith-based organizations. Using the Apostolic Faith Mission in Zimbabwe church as a point of reference, this article argues that in Christian circles there is need to deliberately develop a perspective of conflict that reflects conflict as a positive force that generates both co-existence and growth in the church to counter the conventional view in the majority of churches that consider conflict as a destructive force. In the Apostolic Faith Mission church, intra-church disputes have a negative effect on the wellbeing of individuals and groups (the church) as conflict creates rivalry, hostility, divisions, hate, breakaways, among others. This is because a strongly adversarial attitude to conflict of all sorts is reflected in the approach of the church to conflict and in particular, some pastors have responded with legal action against the disciplinary activities of the church. Consequently, this article suggests that faith-based organizations should appreciate the importance of conflict for positive growth and development as a good number of Christians today are still pessimistic about conflict.


2016 ◽  
Vol 3 (3) ◽  
Author(s):  
Teesta Saksena ◽  
Dr. Ritu Sharma

This article has been withdrawn at the request of the author(s) and or editor. The Publisher apologizes for any inconvenience this may cause.


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