A functional division of Drosophila sweet taste neurons that is value-based and task-specific

Sucrose is an attractive feeding substance and a positive reinforcer for Drosophila. But Drosophila females have been shown to robustly reject a sucrose-containing option for egg-laying when given a choice between a plain and a sucrose-containing option in specific contexts. How the sweet taste system of Drosophila promotes context-dependent devaluation of an egg-laying option that contains sucrose, an otherwise highly appetitive tastant, is unknown. Here, we report that devaluation of sweetness/sucrose for egg-laying is executed by a sensory pathway recruited specifically by the sweet neurons on the legs of Drosophila. First, silencing just the leg sweet neurons caused acceptance of the sucrose option in a sucrose versus plain decision, whereas expressing the channelrhodopsin CsChrimson in them caused rejection of a plain option that was “baited” with light over another that was not. Analogous bidirectional manipulations of other sweet neurons did not produce these effects. Second, circuit tracing revealed that the leg sweet neurons receive different presynaptic neuromodulations compared to some other sweet neurons and were the only ones with postsynaptic partners that projected prominently to the superior lateral protocerebrum (SLP) in the brain. Third, silencing one specific SLP-projecting postsynaptic partner of the leg sweet neurons reduced sucrose rejection, whereas expressing CsChrimson in it promoted rejection of a light-baited option during egg-laying. These results uncover that the Drosophila sweet taste system exhibits a functional division that is value-based and task-specific, challenging the conventional view that the system adheres to a simple labeled-line coding scheme.

Sensory computations in the cuneate nucleus of macaques

Tactile nerve fibers fall into a few classes that can be readily distinguished based on their spatiotemporal response properties. Because nerve fibers reflect local skin deformations, they individually carry ambiguous signals about object features. In contrast, cortical neurons exhibit heterogeneous response properties that reflect computations applied to convergent input from multiple classes of afferents, which confer to them a selectivity for behaviorally relevant features of objects. The conventional view is that these complex response properties arise within the cortex itself, implying that sensory signals are not processed to any significant extent in the two intervening structures—the cuneate nucleus (CN) and the thalamus. To test this hypothesis, we recorded the responses evoked in the CN to a battery of stimuli that have been extensively used to characterize tactile coding in both the periphery and cortex, including skin indentations, vibrations, random dot patterns, and scanned edges. We found that CN responses are more similar to their cortical counterparts than they are to their inputs: CN neurons receive input from multiple classes of nerve fibers, they have spatially complex receptive fields, and they exhibit selectivity for object features. Contrary to consensus, then, the CN plays a key role in processing tactile information.

Nanostructure Analysis of Anodic Films Formed on Aluminum-Focusing on the Effects of Electric Field Strength and Electrolyte Anions

In this review, the research conducted by the authors on anodic oxide films on aluminum is described, paying particular attention to how the electric field strength, as a factor other than voltage, controls the nanostructures and properties of the films. It will also be indicated what factors contribute to the formation of defects, which, in contrast to the ideal or model film structure, contains a significant number of defects in the film. In addition to electrochemical measurements, the films were examined with a variety of advanced instruments, including electron microscopes, to confirm the “reality of film nanostructure” from a slightly different angle than the conventional view. The following topics on anodic films formed in four types of major anodizing electrolytes are discussed: pore initiation process, steady-state porous structure, sealing mechanism, the relationship between cell parameters and voltage/electric field strength, amount and depth of anion incorporation, electrolyte types, radial branching of pores, atypical pore structures, defect formation mechanism, self-ordering, Al coordination number, and the creation of α-alumina membranes.

A recurrent circuit links antagonistic cerebellar modules during associative motor learning

The neural architecture of the cerebellum is thought to be specialized for performing supervised learning: specific error-related climbing fiber inputs are used to teach sensorimotor associations to small ensembles of Purkinje cells located in functionally distinct modules that operate independently of each other in a purely feedforward manner. Here, we test whether the basic operation of the cerebellum complies with this basic architecture in mice that learned a simple sensorimotor association during eyeblink conditioning. By recording Purkinje cells in different modules and testing whether their responses rely on recurrent circuits, our results reveal three operational principles about the functional organization of the cerebellum that stand in stark contrast to the conventional view: (1) Antagonistic organization, (2) Recurrent network dynamics, and (3) Intermodular communication. We propose that the neural architecture of the cerebellum implements these three operational principles to achieve optimal performance and solve a number of problems in motor control.

The meaning of nursing practice for nurses who are retired yet continue to work in a rural or remote community

Background Although much research has focused on nurses’ retirement intentions, little is known about nurses who formally retire yet continue to practice, particularly in rural and remote settings where mobilization of all nurses is needed to assure essential health services. To optimize practice and sustain the workforce stretched thin by the COVID-19 pandemic, it is necessary to understand what it means for retired registered nurses (RNs) and licensed practical nurses (LPNs) to work after retirement. This study explored what nursing practice means for RNs and LPNs who have formally retired but continue to practice in rural and remote communities. Methods A pan-Canadian cross-sectional survey conducted in 2014–2015 of nurses in rural and remote Canada provided data for analysis. Textual responses from 82 RNs and 19 LPNs who indicated they had retired but were occasionally employed in nursing were interpreted hermeneutically. Results Retired nurses who continued to practice took on new challenges as well as sought opportunities to continue to learn, grow, and give back. Worklife flexibility was important, including having control over working hours. Nurses’ everyday practice was inextricably tied up with their lives in rural and remote communities, with RNs emphasizing serving their communities and LPNs appreciating community recognition and the family-like character of their work settings. Conclusions Retired nurses who continue to work in nursing see retirement as the next phase in their profession and a vital way of engaging with their rural and remote communities. This study counters the conventional view of retaining retired nurses only to combat nursing shortages and alleviate a knowledge drain from the workplace. Rural and remote nurses who retire and continue working contribute to their workplaces and communities in important and innovative ways. They can be characterized as dedicated, independent, and resilient. Transitioning to retirement in rural and remote practice can be re-imagined in ways that involve both the community and the workplace. Supporting work flexibility for retired nurses while facilitating their practice, technological acumen, and professional development, can allow retired nurses to contribute their joy of being a nurse along with their extensive knowledge and in-depth experience of nursing and the community.

Public R&D and Science – Industry Links in Economic Development: Implications for Bosnia and Herzegovina

The paper presents the current understanding of the role of public R&D in economic growth and the science–industry links from middle-income economies like Bosnia and Herzegovina (BiH). In the second part, we present the conventional view on science–industry links which see these linkages primarily in terms of a one-way transfer of knowledge or its commercialisation from R&D to the business enterprise sector. Based on the comparative data, which also includes BiH, we show an alternative approach and argue about its relevance in the context of BiH. Our conclusion is that science–industry links (SIL) should support technology upgrading and not (or not only) R&D based growth. In the next section, we present the current understanding of the role of public R&D in economic growth. Section two explores the role of public R&D in the catching up context, while section 3 explores specifically the role of science-industry links in catching up context. Section 4 proposes a ‘Triple Helix’ approach to science - industry linkages for catching up economies. We illustrate its features within the data for the central and east European economies. Finally, section 5 concludes with implications for BiH

Relative Contributions of Mg Hydration and Molecular Structural Restraints to the Barrier of Dolomite Crystallization: A Comparison of Aqueous and Non-Aqueous Crystallization in (BaMg)CO3 and (CaMg)CO3 Systems

Carbonate mineralization is reasonably well-understood in the Ca–CO2–H2O system but continuously poses difficulties to grasp when Mg is present. One of the outstanding questions is the lack of success in dolomite MgCa(CO3)2 crystallization at atmospheric conditions. The conventional view holds that hydration retards the reactivity of Mg2+ and is supported by solvation shell chemistry. This theory however is at odds with the easy formation of norsethite MgBa(CO3)2, a structural analogue of dolomite, leading to the premise that crystal or molecular structural constrains may also be at play. The present study represents our attempts to evaluate the separate contributions of the two barriers. Crystallization in the Mg–Ba–CO2 system was examined in a non-aqueous environment and in H2O to isolate the effect of hydration by determining the minimal relative abundance of Mg required for norsethite formation. The results, showing an increase from 1:5 to 6:4 in the solution Mg/Ba ratio, represented a ~88% reduction in Mg2+ reactivity, presumably due to the hydration effect. Further analyses in the context of transition state theory indicated that the decreased Mg2+ reactivity in aqueous solutions was equivalent to an approximately 5 kJ/mol energy penalty for the formation of the activated complex. Assuming the inability of dolomite to crystallizes in aqueous solutions originates from the ~40 kJ/mol higher (relative to norsethite) Gibbs energy of formation for the activated complex, a hydration effect was estimated to account for ~12% of the energy barrier. The analyses present here may be simplistic but nevertheless consistent with the available thermodynamic data that show the activated complex of dolomite crystallization reaction is entropically favored in comparison with that of norsethite formation but is significantly less stable due to the weak chemical bonding state.

Did the Poona Pact Disenfranchise the ‘Depressed Classes’? An Analysis of the 1936–1937 and 1945–1946 Provincial Elections

This article contests the conventional view that the ‘Depressed Classes’ lost out on representation by agreeing to joint electorates in the Poona Pact. It analyses the results of the elections to the provincial legislatures in British India that took place in 1936–1937 and 1945–1946 under the Government of India Act, 1935, to concretely appraise the working of the Poona Pact. The article argues that reserved seats, primary elections and cumulative voting redeemed the ability of the Poona Pact to provide both descriptive and substantive representation for the ‘Depressed Classes’.

Resurgence of Large Class Sizes and Pedagogical Reform in 21st Century Secondary School History Classrooms

This paper examines the interaction between class size and teachers’ selection of teaching methods while implementing a new history curriculum in Zimbabwean secondary schools. Policy makers, parents, teachers, and students are worried about large class sizes because they are associated with higher dropout rates, less teacher-student interaction and rote pedagogy. Although class sizes had significantly declined in the latter half of the 20th century, the growth of online learning has witnessed class sizes ballooning in the 21st century, reigniting the class size debate. The large class size challenge has re-emerged in the developed North although the problem has never been resolved in the developing South. Using the theoretical lens of symbolic interactionism and a qualitative multiple case-study approach, data were collected over an eight-week period using document analysis, semi-structured interviews and lesson observations. Results seem to challenge the conventional view that large classes coerce teachers to use rote pedagogy and small classes encourage learner-centric practices. Teachers’ choices of teaching methods were neither linked to class size nor new pedagogical policy. Instead, teachers’ personal philosophy to instruction appeared to be the decisive factor to the teaching methods they used, rather than the size of the class. To promote pedagogical change, improving teacher quality appears a more valuable and cheaper investment than constructing new schools and employing more teachers to reduce class sizes.

Self-Made Farmers and Sustainable Change?

We studied livelihood changes and poverty dynamics over a twenty-five-year period in two villages in central Tanzania. The villages were, from the early 1990s and 2000s, strikingly poor with between 50 per cent and 55 per cent of families in the poorest wealth groups. Twenty-five years later much has changed: people have become substantially wealthier, with 64 per cent and 71 per cent in the middle wealth groups. The new wealth had been generated locally, from farming, particularly of sunflowers as a cash crop. This goes against a conventional view of small-scale farming in Tanzania as being stagnant or unproductive. The area of land farmed per family has increased, almost doubling in one village. People have made money, which they invest in mechanized farming, improved housing, education of their children, livestock, and consumer goods. Improved infrastructure and local entrepreneurs have played key roles in the area’s transformation. Locally identified wealth rankings showed that most villagers, those in the middle wealth groups and above, can now support themselves from their land, which is a notable change to a time when 71 per cent and 82 per cent in each village respectively depended on casual labour for their survival. This change has come at a cost to the environment. By 2016, the village forests have largely gone and been replaced by farms. Farmers were concerned that the climate was turning drier because of deforestation. Satellite data confirms extensive forest loss in this location. Studying the mundane—the material used in roofs, the size of farms, and so on—made it possible to trace and understand the radical transition the area has experienced.