scholarly journals Changes in proteomic profiles in different prostate lobes of male rats throughout growth and development and aging stages of the life span

The Prostate ◽  
2012 ◽  
Vol 73 (4) ◽  
pp. 363-375 ◽  
Author(s):  
Arunangshu Das ◽  
James D. Bortner ◽  
Cesar A. Aliaga ◽  
Aaron Baker ◽  
Anne Stanley ◽  
...  
Keyword(s):  
Life Span ◽  
Growth And Development ◽  
Male Rats ◽  
Development And Aging

Positive growth and development: From distress to coping across the life-span

2010 ◽  
Author(s):  
Erica Frydenberg ◽  
Krys Kaniasty ◽  
Erica Frydenberg ◽  
Barbara Jones ◽  
Esther Greenglass ◽  
...  
Keyword(s):  
Life Span ◽  
Growth And Development ◽  
Positive Growth

scholarly journals Altered miRNA and mRNA Expression in Sika Deer Skeletal Muscle with Age

Genes ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 172
Author(s):  
Boyin Jia ◽  
Yuan Liu ◽  
Qining Li ◽  
Jiali Zhang ◽  
Chenxia Ge ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth And Development ◽  
Molecular Mechanisms ◽  
Muscle Development ◽  
Sika Deer ◽  
De Novo ◽  
Expression Profiles ◽  
Differentially Expressed ◽  
Growth Development ◽  
Development And Aging

Studies of the gene and miRNA expression profiles associated with the postnatal late growth, development, and aging of skeletal muscle are lacking in sika deer. To understand the molecular mechanisms of the growth and development of sika deer skeletal muscle, we used de novo RNA sequencing (RNA-seq) and microRNA sequencing (miRNA-seq) analyses to determine the differentially expressed (DE) unigenes and miRNAs from skeletal muscle tissues at 1, 3, 5, and 10 years in sika deer. A total of 51,716 unigenes, 171 known miRNAs, and 60 novel miRNAs were identified based on four mRNA and small RNA libraries. A total of 2,044 unigenes and 11 miRNAs were differentially expressed between adolescence and juvenile sika deer, 1,946 unigenes and 4 miRNAs were differentially expressed between adult and adolescent sika deer, and 2,209 unigenes and 1 miRNAs were differentially expressed between aged and adult sika deer. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that DE unigenes and miRNA were mainly related to energy and substance metabolism, processes that are closely associate with the growth, development, and aging of skeletal muscle. We also constructed mRNA–mRNA and miRNA–mRNA interaction networks related to the growth, development, and aging of skeletal muscle. The results show that mRNA (Myh1, Myh2, Myh7, ACTN3, etc.) and miRNAs (miR-133a, miR-133c, miR-192, miR-151-3p, etc.) may play important roles in muscle growth and development, and mRNA (WWP1, DEK, UCP3, FUS, etc.) and miRNAs (miR-17-5p, miR-378b, miR-199a-5p, miR-7, etc.) may have key roles in muscle aging. In this study, we determined the dynamic miRNA and unigenes transcriptome in muscle tissue for the first time in sika deer. The age-dependent miRNAs and unigenes identified will offer insights into the molecular mechanism underlying muscle development, growth, and maintenance and will also provide valuable information for sika deer genetic breeding.

Comparative migration, growth and development of Typhlocoelum cucumerinum sisowi in dabbling ducks and Typhlocoelum cucumerinum cucumerinum in diving ducks

Parasitology ◽  
1982 ◽  
Vol 84 (2) ◽  
pp. 333-350 ◽  
Author(s):  
Marilyn E. Scott ◽  
M. E. Rau ◽  
J. D. McLaughlin
Keyword(s):  
Life Cycle ◽  
Life Span ◽  
Definitive Host ◽  
Host Species ◽  
Growth And Development ◽  
Abdominal Cavity ◽  
Dabbling Ducks ◽  
Diving Ducks ◽  
Air Sacs ◽  
Aythya Valisineria

SUMMARYExperimental infections of mallards (Anas platyrhynchos L.) with Typhlocoelum cucumerinum sisowi (Skrjabin, 1913) and of canvasbacks (Aythya valisineria (Wilson)) with Typhlocoelum cucumerinum cucumerinum (Rudolphi, 1809) revealed significant differences in various parameters of the life-cycle in the definitive host. Both T. c. sisowi and T. c. cucumerinum migrate to the trachea via the abdominal cavity, air sacs and lungs, although T. c. cucumerinum migrate more quickly and more synchronously than T. c. sisowi. Typhlocoelum c. sisowi has a shorter expected life-span than T. c. cucumerinum but grows and reaches maturity more quickly than T. c. cucumerinum. Evidence suggests that T. c. cucumerinum has a higher fecundity than T. c. sisowi. These differences in the patterns of migration, growth and development are related not only to differences between the two host species but also to differences intrinsic to the parasites, and serve to provide biological support for considering them as separate sub-species.

Life Span Study of SPF Fischer 344 Male Rats Fed AdLibitum or Restricted Diets: Longevity, Growth, Lean Body Mass and Disease

1982 ◽  
Vol 37 (2) ◽  
pp. 130-141 ◽  
Author(s):  
B. P. Yu ◽  
E. J. Masoro ◽  
I. Murata ◽  
H. A. Bertrand ◽  
F. T. Lynd
Keyword(s):  
Life Span ◽  
Lean Body Mass ◽  
Body Mass ◽  
Male Rats ◽  
Life Span Study ◽  
Fischer 344

Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in healthy human volunteers

Blood ◽  
2000 ◽  
Vol 95 (8) ◽  
pp. 2514-2522 ◽  
Author(s):  
Laurence A. Harker ◽  
Lorin K. Roskos ◽  
Ulla M. Marzec ◽  
Richard A. Carter ◽  
Judith K. Cherry ◽  
...  
Keyword(s):  
Life Span ◽  
Binding Sites ◽  
Growth And Development ◽  
Annexin V ◽  
Normal Function ◽  
Healthy Human ◽  
Platelet Production ◽  
Platelet Counts ◽  
Development Factor ◽  
Human Volunteers

The effects of thrombopoietic stimulation on megakaryocytopoiesis, platelet production, and platelet viability and function were examined in normal volunteers randomized to receive single bolus subcutaneous injections of 3 μg/kg pegylated recombinant megakaryocyte growth and development factor (PEG-rHuMGDF) or placebo in a 3:1 ratio. PEG-rHuMGDF transiently doubled circulating platelet counts, from 237 ± 41 × 103/μL to 522 ± 90 × 103/μL (P< .0001), peaking on day 12. Baseline and day-12 samples showed no differences in responsiveness of platelets to adenosine diphosphate or thrombin receptor agonist peptide (P > .4 in all cases); expression of platelet ligand-induced binding sites or annexin V binding sites (P > .6 in both cases); or density of platelet TPO-receptors (P > .5). Platelet counts normalized by day 28. The life span of autologous 111In-labeled platelets increased from 205 ± 18 hours (baseline) to 226 ± 22 hours (P < .01) on day 8. Platelet life span decreased from 226 ± 22 hours (day 8) to 178 ± 53 hours (P < .05) on day 18. The theoretical basis for senescent changes in mean platelet life span was illustrated by biomathematical modeling. Platelet turnover increased from 43.9 ± 11.9 × 103 platelets/μL/d (baseline) to 101 ± 27.6 × 103 platelets/μL/d (P = .0009), and marrow megakaryocyte mass expanded from 37.4 ± 18.5 fL/kg to 62 ± 17 × 1010 fL/kg (P = .015). Although PEG-rHuMGDF initially increased megakaryocyte volume and ploidy, subsequently ploidy showed a transient reciprocal decrease when the platelet counts exceeded placebo values. In healthy human volunteers PEG-rHuMGDF transiently increases megakaryocytopoiesis 2-fold. Additionally, peripheral platelets expand correspondingly and exhibit normal function and viability during the ensuing 10 days. The induced perturbation in steady state thrombopoiesis resolves by 4 weeks.

THE EFFECTS OF DIETARY ZINC DEFICIENCY ON THE REPRODUCTIVE SYSTEM OF MALE RATS

1958 ◽  
Vol 36 (6) ◽  
pp. 557-569 ◽  
Author(s):  
M. J. Millar ◽  
M. I. Fischer ◽  
P. V. Elcoate ◽  
C. A. Mawson
Keyword(s):  
Zinc Deficiency ◽  
Growth And Development ◽  
Zinc Concentration ◽  
Testicular Atrophy ◽  
Male Rats ◽  
Dietary Zinc ◽  
Poor Diet ◽  
Weanling Rats ◽  
Body Weights ◽  
Pituitary Glands

Dietary zinc deficiency produced by feeding a zinc-poor diet (0.5 μg. zinc per g.) to weanling rats for 8 weeks caused marked retardation in body growth, depressed growth and development of testes, epididymes, accessory sex organs, and pituitary glands, and in many cases severe atrophy of testicular germinal epithelium. The zinc concentration of dorsolateral prostates, testes, epididymes, and bone was reduced in zinc-deficient rats compared with controls receiving the zinc-poor diet plus 100 μg. zinc daily. Restricted feeding of the zinc-supplemented diet to produce body weights comparable to those in zinc-deficient rats caused a reduction in pituitary gland and accessory sex organ size which was similar to that observed in zinc-deficient rats. Testis growth and development were normal in the restricted controls and did not differ from controls fed ad libitum. The zinc concentration of dorsolateral prostates was reduced in restricted controls but exceeded that in the zinc-deficient rats. All the observed changes produced by zinc deficiency except the testicular atrophy were reversed when zinc was replaced in the diet. If testicular atrophy had occurred, neither testis nor epididymis regained normal size, function, or zinc concentration.

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