Characterization of some Urinary Protein Fractions in Patients with Multiple Myeloma

Nature ◽  
1962 ◽  
Vol 196 (4853) ◽  
pp. 480-481 ◽  
Author(s):  
H. WEICKER ◽  
K. HUHNSTOCK
Keyword(s):  
Multiple Myeloma ◽  
Urinary Protein ◽  
Protein Fractions

scholarly journals Bone Pain in Multiple Myeloma (BPMM)—A Protocol for a Prospective, Longitudinal, Observational Study

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1596
Author(s):  
Marta Diaz-delCastillo ◽  
Rebecca E. Andrews ◽  
Aritri Mandal ◽  
Thomas L. Andersen ◽  
Andrew D. Chantry ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Myeloma ◽  
Observational Study ◽  
Bone Turnover ◽  
Bone Pain ◽  
Subjective Experience ◽  
Prospective Longitudinal ◽  
Bone Turnover Biomarkers

Multiple myeloma (MM) is a bone marrow neoplasia that causes bone pain in 70% patients. While preclinical models of MM have suggested that both nerve sprouting and nerve injury may be causative for the pain, there is a lack of clinical data. Thus, the primary aims of this clinical study are: (1) to provide a deep characterization of the subjective experience of pain and quality of life in MM patients; (2) to investigate disturbances in the bone innervation of MM patients. Secondary aims include exploring correlations between pain and serum inflammatory and bone turnover biomarkers. In a prospective, observational study (clinicaltrials.gov: NCT04273425), patients with suspected MM requiring a diagnostic iliac crest biopsy at Sheffield Teaching Hospital (UK) are invited to participate. Consenting patients answer seven standardized questionnaires assessing pain, quality of life and catastrophizing. Bone turnover biomarkers and inflammatory cytokines are measured in fasting serum samples, and bone innervation is evaluated in diagnostic biopsies. MM patients are invited to a follow-up upon completion of first line treatment. This will be the first deep characterization of pain in MM patients and its correlation with disturbances in bone innervation. Understanding how bone turnover and inflammation correlate to pain in MM is crucial to identify novel analgesic targets for this condition.

scholarly journals Identification and Characterization of Multiple Myeloma Stem Cell-Like Cells

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3523
Author(s):  
Wancheng Guo ◽  
Haiqin Wang ◽  
Peng Chen ◽  
Xiaokai Shen ◽  
Boxin Zhang ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Drug Resistance ◽  
Stem Cell ◽  
New Drugs ◽  
Cell Therapies ◽  
High Relapse Rate ◽  
High Incidence ◽  
Poorly Differentiated ◽  
Identification And Characterization

Multiple myeloma (MM) is a B-cell tumor of the blood system with high incidence and poor prognosis. With a further understanding of the pathogenesis of MM and the bone marrow microenvironment, a variety of adjuvant cell therapies and new drugs have been developed. However, the drug resistance and high relapse rate of MM have not been fundamentally resolved. Studies have shown that, in patients with MM, there is a type of poorly differentiated progenitor cell (MM stem cell-like cells, MMSCs). Although there is no recognized standard for identification and classification, it is confirmed that they are closely related to the drug resistance and relapse of MM. This article therefore systematically summarizes the latest developments in MMSCs with possible markers of MMSCs, introduces the mechanism of how MMSCs work in MM resistance and recurrence, and discusses the active pathways that related to stemness of MM.

scholarly journals Characterization of rare germline variants in familial multiple myeloma

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
Calogerina Catalano ◽  
Nagarajan Paramasivam ◽  
Joanna Blocka ◽  
Sara Giangiobbe ◽  
Stefanie Huhn ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Germline Variants

Characterization of hematopoietic stem cell subsets from patients with multiple myeloma after mobilization with plerixafor

Cytotherapy ◽  
2011 ◽  
Vol 13 (4) ◽  
pp. 459-466 ◽  
Author(s):  
Isabel Taubert ◽  
Rainer Saffrich ◽  
Abraham Zepeda-Moreno ◽  
Isabelle Hellwig ◽  
Volker Eckstein ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem

Large-scale N-glycoproteome map of rat brain tissue: Simultaneous characterization of insoluble and soluble protein fractions

PROTEOMICS ◽  
2011 ◽  
Vol 11 (21) ◽  
pp. 4274-4278 ◽  
Author(s):  
Xiaoqiang Qiao ◽  
Dingyin Tao ◽  
Yanyan Qu ◽  
Liangliang Sun ◽  
Liang Gao ◽  
...  
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Soluble Protein ◽  
Large Scale ◽  
Protein Fractions ◽  
Rat Brain Tissue

scholarly journals CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. I. THE CHARACTERIZATION OF THE PROTEIN FRACTIONS OF HUMAN PLASMA 12

1944 ◽  
Vol 23 (4) ◽  
pp. 417-432 ◽  
Author(s):  
Edwin J. Cohn ◽  
John L. Oncley ◽  
Laurence E. Strong ◽  
Walter L. Hughes ◽  
S. Howard Armstrong
Keyword(s):  
Human Plasma ◽  
Protein Fractions
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