Aldosterone synthase (CYP11B2) C-344T polymorphism affects the association of age-related changes of the serum C-reactive protein

Abstract Purpose To describe the clinical features of COVID-19 in older adults, and relate these to outcomes. Methods A cohort study of 217 individuals (median age 80, IQR 74–85 years; 62% men) hospitalised with COVID-19, followed up for all-cause mortality, was conducted. Secondary outcomes included cognitive and physical function at discharge. C-reactive protein and neutrophil:lymphocyte ratio were used as measures of immune activity. Results Cardinal COVID-19 symptoms (fever, dyspnoea, cough) were common but not universal. Inflammation on hospitalisation was lower in frail older adults. Fever, dyspnoea, delirium and inflammation were associated with mortality. Delirium at presentation was an independent risk factor for cognitive decline at discharge. Conclusions COVID-19 may present without cardinal symptoms as well as implicate a possible role for age-related changes in immunity in mediating the relationship between frailty and mortality.

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Presenting features of COVID-19 in older people: relationships with frailty, inflammation and mortality

10.1101/2020.06.07.20120527 ◽

2020 ◽

Cited By ~ 1

Author(s):

Paul Knopp ◽

Amy Miles ◽

Thomas E Webb ◽

Benjamin C Mcloughlin ◽

Imran Mannan ◽

...

Keyword(s):

Older Adults ◽

Older Individuals ◽

C Reactive Protein ◽

Immune Activity ◽

Neutrophil Lymphocyte Ratio ◽

Reactive Protein ◽

Age Related ◽

Cardinal Symptoms ◽

The Relationship ◽

Age Related Changes

AbstractPurposeTo describe the clinical features of COVID-19 in older adults, and relate these to outcomes.MethodsCohort study of 217 individuals (≥70 years) hospitalised with COVID-19, followed up for allcause mortality. Secondary outcomes included cognitive and physical function at discharge. C-reactive protein and neutrophil: lymphocyte ratio were used as measures of immune activity.ResultsCardinal COVID-19 symptoms (fever, dyspnoea, cough) were common but not universal. Inflammation on hospitalisation was lower in frail older adults. Fever, dyspnoea, delirium and inflammation were associated with mortality. Delirium at presentation was an independent risk factor for cognitive decline at discharge.ConclusionsCOVID-19 may present without cardinal symptoms as well as implicate a possible role for age-related changes in immunity in mediating the relationship between frailty and mortality.Key summary pointsAimTo characterise symptoms, key findings and clinical outcomes in older adults with COVID-19Findings12% of older individuals did not present with classical COVID-19 symptoms, though fever, dyspnoea, delirium and raised inflammation were associated with higher mortality. Compared with fitter older individuals, immune activity was lower in frailer patients.MessageCOVID-19 may present without cardinal symptoms as well as implicate a possible role for age-related changes in immunity in mediating the relationship between frailty and mortality.

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Effects of Caloric Restriction and Exercise on Age-Related, Chronic Inflammation Assessed by C-Reactive Protein and Interleukin-6

The Journals of Gerontology Series A ◽

10.1093/gerona/61.3.211 ◽

2006 ◽

Vol 61 (3) ◽

pp. 211-217 ◽

Cited By ~ 57

Author(s):

R. Kalani ◽

S. Judge ◽

C. Carter ◽

M. Pahor ◽

C. Leeuwenburgh

Keyword(s):

Chronic Inflammation ◽

Caloric Restriction ◽

Interleukin 6 ◽

C Reactive Protein ◽

Reactive Protein ◽

Age Related

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C-reactive protein isoforms differentially affect outer blood-retinal barrier integrity and function

AJP Cell Physiology ◽

10.1152/ajpcell.00057.2016 ◽

2017 ◽

Vol 312 (3) ◽

pp. C244-C253 ◽

Cited By ~ 7

Author(s):

Blanca Molins ◽

Anna Pascual ◽

Méndez ◽

Victor Llorenç ◽

Javier Zarranz-Ventura ◽

...

Keyword(s):

Pigment Epithelium ◽

Retinal Pigment ◽

Protein Isoforms ◽

Age Related Macular Degeneration ◽

C Reactive Protein ◽

Barrier Dysfunction ◽

Blood Retinal Barrier ◽

Reactive Protein ◽

Anti Vegf ◽

Age Related

The retinal pigment epithelium (RPE) forms the outer blood-retinal barrier (oBRB) and is the prime target of early age-related macular degeneration (AMD). C-reactive protein (CRP), a serum biomarker for chronic inflammation and AMD, presents two different isoforms, monomeric (mCRP) and pentameric (pCRP), that may have a different effect on inflammation and barrier function in the RPE. The results reported in this study suggest that mCRP but not pCRP impairs RPE functionality by increasing paracellular permeability and disrupting the tight junction proteins ZO-1 and occludin in RPE cells. Additionally, we evaluated the effect of drugs commonly used in clinical settings on mCRP-induced barrier dysfunction. We found that a corticosteroid (methylprednisolone) and an anti-VEGF agent (bevacizumab) prevented mCRP-induced ARPE-19 barrier disruption and IL-8 production. Furthermore, bevacizumab was also able to revert mCRP-induced IL-8 increase after mCRP stimulation. In conclusion, the presence of mCRP within retinal tissue may lead to disruption of the oBRB, an effect that may be modified in the presence of corticosteroids or anti-VEGF drugs.

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Chosen Vascular Risk Markers in Pseudoexfoliation Syndrome: An Age-Related Disorder

Journal of Ophthalmology ◽

10.1155/2017/5231095 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Hanna Lesiewska ◽

Agnieszka Łukaszewska-Smyk ◽

Grażyna Odrowąż-Sypniewska ◽

Magdalena Krintus ◽

Aneta Mańkowska-Cyl ◽

...

Keyword(s):

Density Lipoprotein ◽

Vascular Diseases ◽

Hdl Cholesterol ◽

High Sensitivity ◽

Serum Levels ◽

Pseudoexfoliation Syndrome ◽

C Reactive Protein ◽

Related Disorder ◽

Reactive Protein ◽

Age Related

Purpose. To evaluate lipids and C-reactive protein serum levels in patients with pseudoexfoliation syndrome (PEX) in the Polish population. Methods. 96 patients were studied with PEX and 79 control subjects. Total cholesterol, triglycerides, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, non-HDL-cholesterol and CRP serum levels, and TG/HDL-C and TC/HDL-C indexes were assessed. Results. There were no significant differences in concentration of lipids and values of TC/HDL-C, TG/HDL-C, and non-HDL-C between PEX and control groups. High-sensitivity C-reactive protein was not increased in patients with PEX. Conclusions. Our results cast doubt on the opinion on the possible PEX and vascular diseases relation. Further studies on this subject are mandatory.

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