scholarly journals Joint effects of prenatal exposure to per- and poly-fluoroalkyl substances and psychosocial stressors on corticotropin-releasing hormone during pregnancy

2021 ◽  
Author(s):  
Stephanie M. Eick ◽  
Dana E. Goin ◽  
Lara Cushing ◽  
Erin DeMicco ◽  
Sabrina Smith ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Life Events ◽  
Prenatal Exposure ◽  
Psychosocial Stress ◽  
Stressful Life Events ◽  
Financial Strain ◽  
Psychosocial Stressors ◽  
Second Trimester ◽  
Cross Sectional ◽  
The Relationship

Abstract Background Prenatal exposure to per- and poly-fluoroalkyl substances (PFAS) and psychosocial stressors has been associated with adverse pregnancy outcomes, including preterm birth. Previous studies have suggested that joint exposure to environmental chemical and social stressors may be contributing to disparities observed in preterm birth. Elevated corticotropin-releasing hormone (CRH) during mid-gestation may represent one biologic mechanism linking chemical and nonchemical stress exposures to preterm birth. Methods Using data from a prospective birth cohort (N = 497), we examined the cross-sectional associations between five individual PFAS (ng/mL; PFNA, PFOA, PFOS, PFHxS, and Me-PFOSA-AcOH) and CRH (pg/mL) using linear regression. PFAS and CRH were measured during the second trimester in serum and plasma, respectively. Coefficients were standardized to reflect change in CRH associated with an interquartile range (IQR) increase in natural log-transformed PFAS. We additionally examined if the relationship between PFAS and CRH was modified by psychosocial stress using stratified models. Self-reported depression, stressful life events, perceived stress, food insecurity, and financial strain were assessed using validated questionnaires during the second trimester and included as binary indicators of psychosocial stress. Results An IQR increase in PFNA was associated with elevated CRH (β = 5.17, 95% confidence interval [CI] = 1.79, 8.55). Increased concentrations of PFOA were also moderately associated with CRH (β = 3.62, 95% CI = −0.42, 7.66). The relationship between PFNA and CRH was stronger among women who experienced stressful life events, depression, food insecurity, and financial strain compared to women who did not experience these stressors. Conclusions This cross-sectional study is the first to examine the relationship between PFAS exposure and CRH levels in mid-gestation. We found that these associations were stronger among women who experienced stress, which aligns with previous findings that chemical and nonchemical stressor exposures can have joint effects on health outcomes.

scholarly journals The Correlation between Psychosocial Stress and Prematurity

2016 ◽  
pp. 55-60
Author(s):  
Renny Aditya
Keyword(s):  
Preterm Birth ◽  
Psychosocial Stress ◽  
Major Change ◽  
Cross Sectional Study ◽  
Living Conditions ◽  
Chi Square ◽  
Cross Sectional ◽  
Term Birth ◽  
Chi Square Test ◽  
The Relationship

Objective: This study was aimed to analyze the relationship between the level of psychosocial stress on preterm birth and term birth. Methods: This was a cross-sectional study, with 45 patients experiencing preterm birth and at term birth, who met the inclusion and exclusion criterias in Obstetrics and Gynecology Department of Dr. Hasan Sadikin Hospital and other hospital nearby. Result: The level of psychosocial stress on preterm birth was severe 64.4 %, moderate 14% and mild 2%. The comparison between the group resulted in p < 0.001 using chi-square test with confidence interval 95% and correlation coefficient was phi = 0.811. The specific psychosocial stressor were problem with in laws (p=0.001), problem with husband (p=0.003), foreclosure on a mortgage or loan (p=0.001), change in residence (p=0.001), major change in living conditions (building a new home, remodeling) (p=0.001), no monetary possession (p=0.001), major change in financial state (p=0.004), environment vulnerability (p=0.035), and being dismissal from work (p=0.014). Conclusion: The relationship between psychosocial stress and preterm birth was significant. The stressor included problem with in laws foreclosure on a mortgage or loan, change in residence, major change in living conditions (building a new home, remodeling, no monetary possesion, major change in financial state, environment vulnerability, and dismissal from work. [Indones J Obstet Gynecol 2012; 36-2: 55-60] Keywords: preterm birth, psychosocial stres

Sleep Reactivity and Psychological Health in Normal Sleepers: the moderating role of stress

2018 ◽  
Author(s):  
Jason G. Ellis ◽  
Sarah Allen ◽  
Michael Perlis ◽  
Michael Grandner ◽  
Maria Gardani ◽  
...  
Keyword(s):  
Life Events ◽  
Psychological Health ◽  
Public Health Campaign ◽  
Health Campaign ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Dysfunctional Cognitions ◽  
The Relationship ◽  
Moderating Role

The aim of the present study was to determine whether normal sleepers with vulnerability to insomnia, via high sleep reactivity, demonstrate more sleep-related dysfunctional cognitions and behaviours and poorer psychological health compared to those who are not vulnerable. Further, the influence of stress on the relationship between sleep reactivity and psychological health was also examined. A cross-sectional survey of 737 young adult ‘normal’ sleepers from the general population was undertaken. Results indicated normal sleepers vulnerable to insomnia demonstrated more sleep-related dysfunctional cognitions and behaviours as well as poorer psychological health compared to those not vulnerable. Furthermore, the relationship between sleep reactivity and psychological health was moderated by perceived stress over the previous month and life events over the previous year. Therefore, identifying and supporting those who are vulnerable to insomnia may be a fruitful avenue for preventative public health campaign to mitigate both insomnia and poor psychological health.

Somatic Distress, Mental Health and Psychological Resilience Among Cancer Patients During the Pandemic: A Cross-Sectional Study

2021 ◽  
Author(s):  
Eser Sağaltıcı ◽  
Özcan Sönmez ◽  
Ebru Karcı ◽  
Şengül Kocamer Şahin ◽  
Arzu Ertürk
Keyword(s):  
Cancer Patients ◽  
Life Events ◽  
Stressful Life Events ◽  
Psychological Symptoms ◽  
Cross Sectional Study ◽  
Stressful Life ◽  
Psychological Resilience ◽  
Cross Sectional ◽  
Somatic Distress ◽  
Stress Symptoms

Abstract Objective The current researches during COVID-19 have not yet addressed somatic distress among cancer patients. The aims of this study are to investigate the somatic distress and psychological symptoms levels of cancer patients, and analyze the influencing factors on somatic distress during the pandemic. Methods This cross-sectional study included consecutively selected 216 eligible cancer patients. The Patient Health Questionnaire-15, Posttraumatic Stress Disorder (PTSD) Checklist for DSM-5, The Depression, Anxiety and Stress Scale-21, the Brief Resilience Scale, the Stressful Life Events List due to Pandemic and, demographic and clinical characteristics form were administered to the participants with face to face interviewing. Results The moderate to severe somatic distress rate was % 38 and probable PTSD rate was 20.4%. Depression, anxiety and stress symptoms were 36.1%, 49.1% and 45.4%, respectively, from mild to extremely severe at any level. There were substantial association between somatic symptoms severity and high PTSD, anxiety, depression, and stress symptoms levels. Low educations levels, high anxiety levels, high experience stressful life events, and low psychological resilience predicted high somatic distress levels. Conclusion This study demonstrates the high risk of somatic distress, PTSD, depression, anxiety and stress in patients with cancer during the pandemic. In addition, somatic distress may indicate high levels of psychological symptoms, high experience stressful life events, and low psychological resilience. It underscores the need to assess psychological status during the pandemic, especially those with high level somatic symptoms.

scholarly journals Dissociative disorders: A study of clinico-demographic profile and associated stressors

2015 ◽  
Vol 3 (2) ◽  
pp. 25-30
Author(s):  
R Thapa
Keyword(s):  
Life Events ◽  
Stressful Life Events ◽  
Age Of Onset ◽  
Dissociative Disorders ◽  
Stressful Life ◽  
Psychosocial Stressors ◽  
Motor Disorder ◽  
Demographic Profile ◽  
Co Morbidity ◽  
One Year

Objectives: To study relevant clinico-demographic profile and stressors of dissociative disorders.  Methods: this is a case control study of 39 cases of dissociative disorders and compared with 39 controls using a self designed questionnaire and G. Singh’s Presumptive Stressful Life Events Scale (PSLE). Results: The mean age of the cases was 21.23 years. Cases of Dissociative motor disorders had significantly higher age (26.4 yrs) as compared to dissociative convulsion (18.8 yrs) and dissociative stupor (20.6 yrs). (38.5%).Two thirds of the cases had comorbid neuro-psychiatric illness, the commonest one being depression (35.9%). The cases had more stressful life events in the past one year as well as whole life when compared to controls. Family conflict was seen to be the commonest precipitating stress.Conclusions: Dissociative disorder mainly affects young people. Dissociative motor disorder is a distinct subtype with a higher age of onset. Presence of neuro-psychiatric co-morbidity is the rule rather than exception. Psychosocial stressors play an important role in disease production.J Psychiatric Association of Nepal Vol .3, No.2, 2014, pp: 25-30DOI: http://dx.doi.org/10.3126/jpan.v3i2.12386 

scholarly journals Psychological stress, stressful life events, male factor infertility, and testicular function: a cross-sectional study

2020 ◽  
Vol 113 (4) ◽  
pp. 865-875 ◽  
Author(s):  
Elvira V. Bräuner ◽  
Loa Nordkap ◽  
Lærke Priskorn ◽  
Åse Marie Hansen ◽  
Anne Kirstine Bang ◽  
...  
Keyword(s):  
Psychological Stress ◽  
Life Events ◽  
Stressful Life Events ◽  
Cross Sectional Study ◽  
Stressful Life ◽  
Testicular Function ◽  
Male Factor Infertility ◽  
Sectional Study ◽  
Male Factor ◽  
Cross Sectional

scholarly journals Factors associated with relapse of schizophrenia

2018 ◽  
Vol 29 (2) ◽  
pp. 59-63
Author(s):  
AKM Akramul Haque ◽  
AHM Kazi Mostofa Kamal ◽  
Zinat De Laila ◽  
Luna Laila ◽  
Helal Uddin Ahmed ◽  
...  
Keyword(s):  
Life Events ◽  
Expressed Emotion ◽  
Stressful Life Events ◽  
Economic Status ◽  
Cross Sectional Study ◽  
High Rate ◽  
Stressful Life ◽  
Cross Sectional ◽  
Significant Difference ◽  
Schizophrenic Patients

Schizophrenia is a chronic psychiatric illness with high rate of relapse which is commonly associated with noncompliance of medicine, as well as stress and high expressed emotions. The objective of the study was to determine the factors of relapse among the schizophrenic patients attending in outpatient departments of three tertiary level psychiatric facilities in Bangladesh. This was a cross sectional study conducted from July, 2001 to June, 2002. Two hundred patients including both relapse and nonrelapse cases of schizophrenia and their key relatives were included by purposive sampling. The results showed no statistically significant difference in terms of relapse with age, sex, religion, residence, occupation and level of education (p>0.05), but statistically significant difference was found with marital status and economic status (p<0.01). The proportion of non-compliance was found to be 80% and 14%, of high expressed emotion was 17% and 2% and of the occurrence of stressful life events was 10% and 1% in relapse and non-relapse cases respectively which were statistically significant (p<0.001). The study indicated that stressful life events, high expressed emotion, and noncompliance with medication had a role in schizophrenic patients for its relapse.Bang J Psychiatry December 2015; 29(2): 59-63

scholarly journals PATIENTS WITH CONVERSION DISORDER

2010 ◽  
Vol 17 (04) ◽  
pp. 715-720
Author(s):  
NIAZ MAQSOOD ◽  
BUSHRA AKRAM ◽  
WAJID ALI
Keyword(s):  
Life Events ◽  
Stressful Life Events ◽  
Case Series ◽  
Strong Relationship ◽  
Conversion Disorder ◽  
Stressful Life ◽  
Psychosocial Stressors ◽  
Medical College ◽  
Case Series Study ◽  
Series Study

Objectives: To assess the frequency of the various psychosocial stressors and stressful life events in patients presenting with conversion disorder. Study Design: Case series study. Place & Duration of Study: The study was conducted in the Department of Psychiatry & Behavioural Sciences, Bahawal Victoria Hospital & Quaid-e-Azam Medical College, Bahawalpur from January, 2009 to March, 2009. Subjects & Methods: The sample consisted of 100 in-patients (89 Female, 11 Male) with Conversion Disorder. They were interviewed andresults were analysed from the entries in a Performa. Results: Stressors were clearly identified in 100 patients. In all patients, we found more than one stressor. Among patients, there were (24%) In-laws problems, (23%) Love problems, (21%) Relationship problems with family, (20%) exam/study stress, (15%) marriage against will, (13%) demanding and pampered child, (11%) Issue less, (10%) sexual abuse, (8%) demand of marriage, (6%) overage in wait of marriage, (4%) death of partner, (3%) husband abroad and (3%) patient’s engagement break. Conclusions: We concluded that stressors and life events were present in all conversion disorder’s patients and these stressful life events are important causal factors for Conversion Disorder. Conversion Disorder has strong relationship with psychosocial stressors. 

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