Detection Rate and Clinical Impact of PET/CT with 18F-FACBC in Patients with Biochemical Recurrence of Prostate Cancer: A Retrospective Bicentric Study

Our aim was to assess the detection rate (DR) of positron emission computed tomography (PET/CT) with anti-1-amino-3-[18F]-flurocyclobutane-1-carboxylic acid (18F-FACBC) in patients with biochemical recurrence (BCR) from prostate cancer (PC). As a secondary endpoint, we evaluated 18F-FACBC PET/CT’s impact on patients management. Clinical records of 81 patients submitted to 18F-FACBC PET/CT due to PC BCR in two Italian Nuclear Medicine Units were retrospectively assessed. DR was gauged in the whole cohort and stratifying patients by discrete intervals of PSA levels. PET/CT’s impact on clinical management was scored as (1) major if it entailed an intermodality change (e.g., from systemic to loco-regional therapy); (2) minor if it led to an intramodality change (e.g., modified radiotherapy field). PET/CT’s DR resulted in 76.9% in the whole cohort, with a positive predictive value of 96.7%. Stratified by PSA quartile intervals, PET/CT’s DR was 66.7%, 71.4%, 78.9% and 90% for PSA 0.2–0.57 ng/mL, 0.58–0.99 ng/mL, 1–1.5 ng/mL and >1.5 ng/mL without significant difference among groups (p = 0.81). The most common sites of relapse were prostate bed and pelvic lymph nodes (59.3%). PET/CT impacted on clinical management in 33/81 cases (40.7%), leading to a major change in 30 subjects (90.9%). 18F-FACBC PET/CT localized recurrence in patients with BCR, with meaningful DR also at low PSA levels and significantly impacted on clinical management.

Editorial Introduction - GROUP 2022 Second Wave

For over a quarter century, GROUP has offered a premier yet intimate and welcoming venue for agenda-setting, diverse research. Although the traditional focus of the conference is on supporting group work, it has expanded to include research from computer-supported cooperative work, sociotechnical studies, practice-centered computing, human-computer interaction, computersupported collaborative learning, participatory technology design, and other related areas. The work presented in this issue embodies that interdisciplinary ethos. Papers in this issue cover a wide range topics, from human-AI collaboration, to collaboration in virtual reality, to perceptions of privacy and security, to the myriad impacts of the COVID-19 pandemic. The application domains are similarly wide ranging, from health data, to civic engagement, to educational settings, to government provision of social services. Similar to the 2021 issue, this issue also continues the tradition of design fiction at GROUP. This issue of PACM:HCI brings you papers from the planned 2022 ACMConference on Supporting Group Work (GROUP 2022). Typically, the GROUP conference occurs every two years. However, research developments do not necessarily follow conference deadline cycles. Thus, the GROUP conference offers authors the opportunity to submit to multiple waves. The first wave of papers for this conference were published in July 2021 in Volume 5 of PACM:HCI, and papers from this current issue were first submitted in May 2021. Both of these sets of papers published as part of the planned GROUP 2022 conference were authored and reviewed during the COVID-19 pandemic. These papers represent commendable volumes of hard work and resilience, not just from the authors, but also from the reviewers, the program committee, and the conference organizers. Additionally, the pandemic forced a major change to the conference at which these papers will be presented.

LEGAL PRACTICES OF INSOLVENCY AND BANKRUPTCY IN INDIA

Bankruptcies have historically followed the business cycle closely. Failure of certain company strategies is a natural part of the market economy’s process. When a firm fails, the optimum outcome for society is a quick renegotiation between financiers, to fund the going concern with a new structure of obligations and a new management team. The purpose of bankruptcy legislation is to recover an entity’s debt and distribute its assets among competing claimholders. As a result, the RBI’s asset quality reviewers identified an extremely high number of NPAs. The government’s most major change is the insolvency and bankruptcy legislation. On the heels of the adoption of the Insolvency and Bankruptcy Code, India jumpedfrom 108thto 52nd in the resolving insolvency category, while its rating improved significantly in dealing with construction permits to 27th from 52nd and trading across borders to 68th from 80th. The purpose of this study is to look into the regulatory framework in India for insolvency and bankruptcy. The impact of insolvency and bankruptcy Code on the Indian economy is also discussed in the study. KEYWORDS: Insolvency, Bankruptcy, Code, Regulatory, SARFAESI Act, National Company Law Appellate Tribunal (NCLAT)

Safeguards for the Future

Safeguards have evolved as a result of new circumstances, institutions, technologies and practices, including cultural phenomena. This chapter examines safeguards from a historical perspective as the product of a political process that resulted in the negotiation of safeguards instruments. In particular, the chapter addresses the IAEA safeguards from the perspective that adaptation of the legal framework for safeguards is necessary and often difficult. Major change will only occur through a political process, not a legal one, involving Member States of the IAEA. The change will be facilitated through the IAEA Secretariat’s role in strengthening safeguards implementation using the power and responsibilities afforded to it; the advancement of technology and techniques as a vital element of this process; and the non-technological aspects of safeguards, particularly the human element.

Designing Tools and Activities for Educational Robotics in Online Learning

The COVID-19 pandemic and the subsequent school closures created several challenges for teachers and students. From one day to the next, teachers had to rethink their educational activities and move to remote learning. Especially with regard to educational robotics activities, which makes large use of physical artefacts, this abrupt shift towards online learning represented a major change in how activities had to be designed and implemented. In this chapter, some experiences of online educational robotics activities carried out in compulsory schooling and teacher training are presented. The experiences are then discussed using a model for the development of educational robotics activities in order to reflect on how to design such activities that can be carried out online. The examples presented in this chapter showed there is great potential for educational robotics in online learning.

High temperature fuel cells to reduce CO2 emission in the maritime sector

Recently the interest in the sustainability of the maritime sector has increased exponentially. The International Maritime Organization (IMO) set as objective the reduction of CO2 emissions by 2030 by a margin of 40% compared to 2008. Recent studies showed that, according to the ships and the emission mitigation method applied, only 15–25% of CO2 reduction is de facto needed. Fuel cells represent an answer to meet this regulation. We propose two different solutions: (i) produce with SOFCs instead of engines the minimum power necessary to cut 20% of the emissions, or (ii) reduce the engine power of about 10% balancing the power requirement using MCFCs with CO2 capture. Using Aspen Plus each solution was investigated. The analysis contemplated LNG steam reforming to produce the H2 necessary for cell operation and the separation and liquefaction of CO2. Two case studies were considered comparing existing passenger ships with engines working on HFO and on LNG respectively. Although both solutions showed potential for the reduction of CO2 emissions respecting the IMO regulations, the SOFC solution requires a major change in the design of the ship, while MCFCs are proposed as an urgent solution allowing ship retrofitting without demanding update.

Digital Technology Deployment in the German Automotive Industry

Mobility is a central element of the new networked world, and customers expect highly integrated features in their vehicles and want to be able to use services or features at any time in a highly integrated manner. As a result, the entire automotive industry is facing a major change process, both technological as well as in its own core business processes and functions. This chapter examines the impact of this transition on the conduct and sustainability of IT projects in the German automotive industry. Information distilled from in-depth interviews with industry practitioners reveals how project management methods, tools, and culture have to evolve, as value chains in the industry are re-evaluated and re-defined. The chapter puts forward a framework for the interaction of project management methods and digital technologies to achieve sustainable project processes and outcomes. It is hoped this may act as a building block for future research in this field to advance the transitioning of the industry and its inherent IT projects to a more sustainable future.

JUDICIAL REFORM OF THE LATE 20TH – EARLY 21ST CENTURIES IN RUSSIA

The author analyzes the reform of the Russian legislation regulating the activity of courts for consideration of civil cases, the reform, which began in the 1990s and continues to this day. Highlights the main stages of the reform related to the adoption of the Constitution of the Russian Federation 1993, changes in the judicial system, with the adoption of the Commercial Procedure Code of the Russian Federation in 1992, 1995, 2002, with a major change of Civil Procedure Code of the RSFSR 1964 and the entry into force of the current Civil Procedure Code of the Russian Federation, 2002. In addition, the author calls the current trends in the development of procedural legislation, including reforms made by Federal Law of 28 November 2018 No. 451-FZ.

Measuring tourism success: alternative considerations

PurposeThe study aims to explore the possibility of redefining success in tourism and measuring such a phenomenon by considering alternatives to economic factors, and to identify the ways such measurement could be implemented.Design/methodology/approachThe study reviews and explains current approaches to defining and measuring success in tourism in the literature, followed by identification of alternative factors which could be measured and the implications of such a change in approach.FindingsThere has been a long-standing emphasis and priority placed on measuring tourism at the national level with a focus on economic criteria, and this has been followed at regional and local levels. The result has been that success has become equated with volume, supporting the aim of continued growth in tourism. Such an approach and attitude mitigate against achieving or moving towards sustainability, and other measures are needed to avoid problems such as overtourism.Originality/valueThere has been little discussion of moving to a wider range of indicators of success in tourism, and the previous focus has been on economic criteria and competitiveness as shown by tourist numbers. This paper presents a discussion of an alternative approach, showing that tourism stakeholders from national to local levels need to redefine success as including factors such as community and environmental well-being and focus on a wider concept of success. Using existing data and organisations would enable measuring such concepts to be done without major change or greatly increased costs to agencies.