scholarly journals Liprins in oncogenic signaling and cancer cell adhesion

Oncogene ◽  
2021 ◽  
Author(s):  
Henna Pehkonen ◽  
Ivan de Curtis ◽  
Outi Monni
Keyword(s):  
Cell Adhesion ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Scaffold Proteins ◽  
Oncogenic Signaling ◽  
Cellular Processes ◽  
Intrinsically Disordered ◽  
Cancer Cell Adhesion ◽  
Neuronal Functions ◽  
Synaptic Structures

AbstractLiprins are a multifunctional family of scaffold proteins, identified by their involvement in several important neuronal functions related to signaling and organization of synaptic structures. More recently, the knowledge on the liprin family has expanded from neuronal functions to processes relevant to cancer progression, including cell adhesion, cell motility, cancer cell invasion, and signaling. These proteins consist of regions, which by prediction are intrinsically disordered, and may be involved in the assembly of supramolecular structures relevant for their functions. This review summarizes the current understanding of the functions of liprins in different cellular processes, with special emphasis on liprins in tumor progression. The available data indicate that liprins may be potential biomarkers for cancer progression and may have therapeutic importance.

scholarly journals The Role of Lipid Rafts in Cancer Cell Adhesion and Migration

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Toshiyuki Murai
Keyword(s):  
Cell Adhesion ◽  
Lipid Rafts ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Migration And Invasion ◽  
Dynamic Features ◽  
Cellular Functions ◽  
Cancer Cell Adhesion ◽  
Cell Adhesion And Migration ◽  
And Migration

Lipid rafts are cholesterol-enriched microdomains of the cell membrane and possess a highly dynamic nature. They have been involved in various cellular functions including the regulation of cell adhesion and membrane signaling through proteins within lipid rafts. The dynamic features of the cancer cell surface may modulate the malignant phenotype of cancer, including adhesion disorders and aggressive phenotypes of migration and invasion. Recently, it was demonstrated that lipid rafts play critical roles in cancer cell adhesion and migration. This article summarizes the important roles of lipid rafts in cancer cell adhesion and migration, with a focus on the current state of knowledge. This article will improve the understanding of cancer progression and lead to the development of novel targets for cancer therapy.

scholarly journals Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Gerd Bendas ◽  
Lubor Borsig
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Biological Activities ◽  
Cellular Adhesion ◽  
Cell Interactions ◽  
Hematogenous Metastasis ◽  
Metastatic Cascade ◽  
Cancer Cell Adhesion

Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell interactions with platelets, leukocytes, and soluble components significantly contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions. Clinical evidence indicates that heparin, commonly used for treatment of thromboembolic events in cancer patients, is beneficial for their survival. Preclinical studies confirm that heparin possesses antimetastatic activities that lead to attenuation of metastasis in various animal models. Heparin contains several biological activities that may affect several steps in metastatic cascade. Here we focus on the role of cellular adhesion receptors in the metastatic cascade and discuss evidence for heparin as an inhibitor of cell adhesion. While P- and L-selectin facilitation of cellular contacts during hematogenous metastasis is being accepted as a potential target of heparin, here we propose that heparin may also interfere with integrin activity and thereby affect cancer progression. This review summarizes recent findings about potential mechanisms of tumor cell interactions in the vasculature and antimetastatic activities of heparin.

scholarly journals Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases

Oncogene ◽  
2020 ◽  
Vol 39 (18) ◽  
pp. 3666-3679 ◽  
Author(s):  
Mario De Piano ◽  
Valeria Manuelli ◽  
Giorgia Zadra ◽  
Jonathan Otte ◽  
Per-Henrik D. Edqvist ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Rho Gtpases ◽  
Prostate Cancer Cell ◽  
Cancer Cell Adhesion ◽  
Cell Adhesion And Migration ◽  
And Migration

scholarly journals CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells

2021 ◽  
Author(s):  
Mattias Lepsenyi ◽  
Nader Algethami ◽  
Amr A. Al-Haidari ◽  
Anwar Algaber ◽  
Ingvar Syk ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Adhesion ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Colon Cancer Cells ◽  
Cancer Cell Adhesion ◽  
And Migration ◽  
Cxcr2 Antagonist

AbstractPeritoneal metastasis is an insidious aspect of colorectal cancer. The aim of the present study was to define mechanisms regulating colon cancer cell adhesion and spread to peritoneal wounds after abdominal surgery. Mice was laparotomized and injected intraperitoneally with CT-26 colon carcinoma cells and metastatic noduli in the peritoneal cavity was quantified after treatment with a CXCR2 antagonist or integrin-αV-antibody. CT-26 cells expressed cell surface chemokine receptors CXCR2, CXCR3, CXCR4 and CXCR5. Stimulation with the CXCR2 ligand, CXCL2, dose-dependently increased proliferation and migration of CT-26 cells in vitro. The CXCR2 antagonist, SB225002, dose-dependently decreased CXCL2-induced proliferation and migration of colon cancer cells in vitro. Intraperitoneal administration of CT-26 colon cancer cells resulted in wide-spread growth of metastatic nodules at the peritoneal surface of laparotomized animals. Laparotomy increased gene expression of CXCL2 at the incisional line. Pretreatment with CXCR2 antagonist reduced metastatic nodules by 70%. Moreover, stimulation with CXCL2 increased CT-26 cell adhesion to extracellular matrix (ECM) proteins in a CXCR2-dependent manner. CT-26 cells expressed the αV, β1 and β3 integrin subunits and immunoneutralization of αV abolished CXCL2-triggered adhesion of CT-26 to vitronectin, fibronectin and fibrinogen. Finally, inhibition of the αV integrin significantly attenuated the number of carcinomatosis nodules by 69% in laparotomized mice. These results were validated by use of the human colon cancer cell line HT-29 in vitro. Our data show that colon cancer cell adhesion and growth on peritoneal wound sites is mediated by a CXCL2-CXCR2 signaling axis and αV integrin-dependent adhesion to ECM proteins.

Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody That Targets Two Distinct Epitopes on αv Integrins

2021 ◽  
pp. 167090
Author(s):  
Eugenio Gallo ◽  
Abdellali Kelil ◽  
Michael Haughey ◽  
Mariana Cazares-Olivera ◽  
Bradley P. Yates ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cancer Cell ◽  
Bispecific Antibody ◽  
Cancer Cell Adhesion

scholarly journals Senescent Peritoneal Mesothelial Cells Promote Ovarian Cancer Cell Adhesion

2009 ◽  
Vol 174 (4) ◽  
pp. 1230-1240 ◽  
Author(s):  
Krzysztof Ksiazek ◽  
Justyna Mikula-Pietrasik ◽  
Katarzyna Korybalska ◽  
Grzegorz Dworacki ◽  
Achim Jörres ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Mesothelial Cells ◽  
Peritoneal Mesothelial Cells ◽  
Cancer Cell Adhesion

Prostate Cancer Cell Adhesion to Bone Marrow Endothelium

2004 ◽  
Vol 64 (6) ◽  
pp. 2083-2089 ◽  
Author(s):  
Victor I. Romanov ◽  
Terry Whyard ◽  
Howard L. Adler ◽  
Wayne C. Waltzer ◽  
Stanley Zucker
Keyword(s):  
Prostate Cancer ◽  
Bone Marrow ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Adhesion
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