scholarly journals Transcriptomic signaling pathways involved in a naturalistic model of inflammation-related depression and its remission

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marie-Pierre Moisan ◽  
Aline Foury ◽  
Sandra Dexpert ◽  
Steve W. Cole ◽  
Cédric Beau ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bariatric Surgery ◽  
Signaling Pathways ◽  
Rating Scale ◽  
Obese Patients ◽  
Genome Expression ◽  
Symptom Intensity ◽  
Before And After ◽  
Apoptosis Pathways ◽  
Whole Genome Expression

AbstractThis study aimed at identifying molecular biomarkers of inflammation-related depression in order to improve diagnosis and treatment. For this, we performed whole-genome expression profiling from peripheral blood in a naturalistic model of inflammation-associated major depressive disorder (MDD) represented by comorbid depression in obese patients. We took advantage of the marked reduction of depressive symptoms and inflammation following bariatric surgery to test the robustness of the identified biomarkers. Depression was assessed during a clinical interview using Mini-International Neuropsychiatric Interview and the 10-item, clinician-administered, Montgomery–Asberg Depression Rating Scale. From a cohort of 100 massively obese patients, we selected 33 of them for transcriptomic analysis. Twenty-four of them were again analyzed 4–12 months after bariatric surgery. We conducted differential gene expression analyses before and after surgery in unmedicated MDD and non-depressed obese subjects. We found that TP53 (Tumor Protein 53), GR (Glucocorticoid Receptor), and NFκB (Nuclear Factor kappa B) pathways were the most discriminating pathways associated with inflammation-related MDD. These signaling pathways were processed in composite z-scores of gene expression that were used as biomarkers in regression analyses. Results showed that these transcriptomic biomarkers highly predicted depressive symptom intensity at baseline and their remission after bariatric surgery. While inflammation was present in all patients, GR signaling over-activation was found only in depressed ones where it may further increase inflammatory and apoptosis pathways. In conclusion, using an original model of inflammation-related depression and its remission without antidepressants, we provide molecular predictors of inflammation-related MDD and new insights in the molecular pathways involved.

scholarly journals Transcriptomic Signaling Pathways involved in a naturalistic model of Inflammation-related Depression and its remission

2020 ◽  
Author(s):  
Marie-Pierre Moisan ◽  
Aline Foury ◽  
Sandra Dexpert ◽  
Steve w Cole ◽  
Cedric Beau ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bariatric Surgery ◽  
Signaling Pathways ◽  
Rating Scale ◽  
Obese Patients ◽  
Symptom Intensity ◽  
Before And After ◽  
Apoptosis Pathways ◽  
Z Scores ◽  
Whole Genome Expression

This study aimed at identifying molecular biomarkers of inflammation-related depression in order to improve diagnosis and treatment. We performed whole-genome expression profiling from peripheral blood in a naturalistic model of inflammation-associated major depressive disorder (MDD) represented by comorbid depression in obese patients. We took advantage of the marked reduction of depressive symptoms and inflammation following bariatric surgery to test the robustness of the identified biomarkers. Depression was assessed during a clinical interview using Mini-International Neuropsychiatric Interview and the 10-item, clinician administered, Montgomery-Asberg Depression Rating Scale. From a cohort of 100 massively obese patients we selected 33 of them for transcriptomic analysis. Twenty-four of them were again analyzed 4-12 months after bariatric surgery. We conducted differential gene expression analyses before and after surgery in unmedicated MDD and non-depressed obese subjects. We found that TP53 (Tumor Protein 53), GR (Glucocorticoid Receptor) and NFκB (Nuclear Factor kappa B) pathways were the most discriminating pathways associated with inflammation-related MDD. These signaling pathways were processed in composite z-scores of gene expression that were used as biomarkers in regression analyses. Results showed that these transcriptomic biomarkers highly predicted depressive symptom intensity at baseline and their remission after bariatric surgery. While inflammation was present in all patients, GR signaling overactivation was found only in depressed ones where it may further increase inflammatory and apoptosis pathways. In conclusion, using an original model of inflammation-related depression and its remission without antidepressants, we provide molecular predictors of inflammation-related MDD and new insights in the molecular pathways involved.

POSTOPERATIVE COMPLIANCE OF BARIATRIC SURGERY PATIENTS REGARDING THE ASSESSMENT OF SERUM LEPTIN LEVELS AND INSULIN RESISTANCE

2019 ◽  
Vol 49 (1/2019) ◽  
Keyword(s):  
Insulin Resistance ◽  
Bariatric Surgery ◽  
Serum Levels ◽  
Medical Laboratory ◽  
Leptin Resistance ◽  
Obese Patients ◽  
Laboratory Assessment ◽  
Serum Leptin ◽  
Before And After ◽  
Bariatric Patients

Background and aims: Overweight and obese patients who undergo bariatric surgery require a rigorous clinical and paraclinical assessment both before and after the surgery at 3, 6, and 12 months.The present study aims the assessment of serum leptin levels and insulin resistance status in compliant bariatric patients to scheduled medical laboratory assessment at 6 months after surgery. Material and Method: The study included 109 eligible patients selected for bariatric surgery, 48 of whom attended the scheduled visit at 6 months after the surgery. Laboratory assessing regarded the insulin resistance by determining before meal the serum levels of leptin, glucose and insulin, as well as HOMA 1 and HOMA 2 indexes. Results: Patients who underwent bariatric treatment experienced a significant decrease in insulin resistance status. A higher percentage in the preoperative group was recorded in women, feature which was also recorded in the postoperative group that attended the scheduled visit at 6 months after surgery. Age is also an important factor that significantly influences the behavioral adherence to postoperative visits. Conclusions: Insulin resistance status improved significantly in 6 months after bariatric surgery among the fully compliant patients. The percentage of attendance at scheduled visits is higher among women, and decreases with age. Keywords: obesity surgery, leptin resistance, insulin resistance, HOMA index, compliance

scholarly journals Fasting and postprandial acyl and desacyl ghrelin and the acyl/desacyl ratio in obese patients before and after different types of bariatric surgery

2018 ◽  
Vol 13 (3) ◽  
pp. 366-375 ◽  
Author(s):  
Jolanta A. Dardzińska ◽  
Łukasz Kaska ◽  
Monika Proczko-Stepaniak ◽  
Maria Szymańska-Gnacińska ◽  
Ewa Aleksandrowicz-Wrona ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Obese Patients ◽  
Desacyl Ghrelin ◽  
Different Types ◽  
Before And After

Progranulin serum levels and gene expression in subcutaneous vs visceral adipose tissue of severely obese patients undergoing bariatric surgery

2019 ◽  
Vol 91 (3) ◽  
pp. 400-410 ◽  
Author(s):  
Judith Brock ◽  
Andreas Schmid ◽  
Thomas Karrasch ◽  
Petra Pfefferle ◽  
Jutta Schlegel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bariatric Surgery ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Serum Levels ◽  
Obese Patients ◽  
Severely Obese ◽  
Visceral Adipose

Whole genome expression as a quantitative trait

2009 ◽  
Vol 37 (6) ◽  
pp. 1276-1277 ◽  
Author(s):  
John Hardy ◽  
Danyah Trabzuni ◽  
Mina Ryten
Keyword(s):  
Gene Expression ◽  
Genetic Variability ◽  
Disease Risk ◽  
Neurological Diseases ◽  
Whole Genome ◽  
Genome Expression ◽  
Genome Analyses ◽  
Whole Genome Expression ◽  
Influence Gene Expression ◽  
Gene Expression Levels

Surprisingly, whole genome analyses of complex human neurological and psychiatric disorders have revealed that many genetic risk factors are likely to influence gene expression rather than alter protein sequences. Previous analyses of neurological diseases have shown that genetic variability in gene expression levels of deposited proteins influence disease risk. With this background, we have embarked on a comprehensive project to determine the effects of common genetic variability on whole genome gene expression.

scholarly journals Toxicity evaluation of manufactured CeO2 nanoparticles before and after alteration: combined physicochemical and whole-genome expression analysis in Caco-2 cells

BMC Genomics ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 700 ◽  
Author(s):  
Matthieu Fisichella ◽  
Frederic Berenguer ◽  
Gerard Steinmetz ◽  
Melanie Auffan ◽  
Jerome Rose ◽  
...  
Keyword(s):  
Expression Analysis ◽  
Ceo2 Nanoparticles ◽  
Whole Genome ◽  
Toxicity Evaluation ◽  
Genome Expression ◽  
Before And After ◽  
Whole Genome Expression

scholarly journals Provision of nutritional support to those experiencing complications following bariatric surgery

2010 ◽  
Vol 69 (4) ◽  
pp. 536-542 ◽  
Author(s):  
Ella Segaran
Keyword(s):  
Bariatric Surgery ◽  
Energy Expenditure ◽  
Hospital Admissions ◽  
Nutrition Support ◽  
Considerable Proportion ◽  
Obese Patients ◽  
Free Living ◽  
Protein Requirements ◽  
Before And After ◽  
Oral Diet

This review details the practicalities of providing nutrition support to obese patients who experience complications following bariatric surgery and highlights some of the nutritional challenges encountered by this group of patients. Bariatric surgery to treat morbid obesity has significantly increased internationally over the past decade with hospital admissions rising annually. The gastric bypass is currently the most commonly performed procedure. The complication rate can be up to 16%, with a considerable proportion having nutritional implications. The treatment can involve avoidance of oral diet and nutrition support, i.e. enteral or parenteral nutrition. Opposition to nutrition support can be encountered. It is useful to clarify the aims of nutrition support, these being: the avoidance of overfeeding and its consequences, preservation of lean body mass and promotion of healing. Evidence suggests that hypoenergic nutrition is not harmful and may actually be beneficial. There is a lack of consensus regarding the optimum method to predict the nutritional requirements in the obese acutely unwell patient. The literature suggests that the predicted equations are fairly accurate compared to measured energy expenditure in free living obese patients before and after bariatric surgery. However, these findings cannot be directly applied to those obese patients experiencing complications of bariatric surgery, who will be acutely unwell exhibiting inflammatory response. It is therefore necessary to refer to the literature on energy expenditure in hospitalized obese patients, to help guide practice. More research examining the energy and protein requirements of obese patients needing nutrition support following bariatric surgery is urgently required.

scholarly journals Physical Activity and Quality of Life of Obese Patients Before and After Bariatric Surgery

2019 ◽  
Vol 2 (6) ◽  
pp. 10-13
Author(s):  
Bruno Leandro de Melo Barreto ◽  
Raphael José Perrier Melo ◽  
Jones Silva Lima ◽  
Rodrigo Conrado de Lorena Medeiros ◽  
Jani Cléria Pereira Bezerra
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Bariatric Surgery ◽  
Obese Patients ◽  
Before And After

scholarly journals Meta-Analysis of Differential miRNA Expression after Bariatric Surgery

2019 ◽  
Vol 8 (8) ◽  
pp. 1220 ◽  
Author(s):  
Gladys Langi ◽  
Lukasz Szczerbinski ◽  
Adam Kretowski
Keyword(s):  
Bariatric Surgery ◽  
Target Genes ◽  
Web Of Science ◽  
Kegg Pathway ◽  
Meta Analysis ◽  
Obese Patients ◽  
Pathway Database ◽  
Efficient Treatment ◽  
Kegg Pathway Database ◽  
Before And After

Bariatric surgery is an efficient treatment for weight loss in obese patients and for resolving obesity comorbidities. However, the mechanisms behind these outcomes are unclear. Recent studies have indicated significant alterations in the transcriptome after surgery, specifically in the differential expression of microRNAs. In order to summarize the recent findings, we conducted a systematic summary of studies comparing microRNA expression levels before and after surgery. We identified 17 animal model and human studies from four databases (Ovid, Scopus, Web of Science, and PubMed) to be enrolled in this meta-analysis. From these studies, we identified 14 miRNAs which had the same direction of modulation of their expression after surgery in at least two studies (downregulated: hsa-miR-93-5p, hsa-miR-106b-5p, hsa-let-7b-5p, hsa-let-7i-5p, hsa-miR-16-5p, hsa-miR-19b-3p, hsa-miR-92a-3p, hsa-miR-222-3p, hsa-miR-142-3p, hsa-miR-140-5p, hsa-miR-155-5p, rno-miR-320-3p; upregulated: hsa-miR-7-5p, hsa-miR-320c). Pathway analysis for these miRNAs was done using database resources (DIANA-TarBase and KEGG pathway database) and their predicted target genes were discussed in relation with obesity and its comorbidities. Discrepancies in study design, such as miRNA source, bariatric surgery type, time of observation after surgery, and miRNA profiling methods, were also discussed.

Sign in / Sign up

Export Citation Format

Share Document