Development of a best-practice clinical guideline for the use of bleomycin in the treatment of germ cell tumours in the UK

Ovarian cancer is the fifth most common cancer in females in the UK. In contrast, testicular cancer is a rare disease: there were 2138 new cases of testicular cancer diagnosed in 2008 in the UK, and only 70 deaths. Ninety per cent of all ovarian cancers are of epithelial origin, although germ cell and sex cord–stromal cell tumours also occur. In contrast, 95% of testicular cancers are germ cell tumours, with stromal cell tumours and lymphomas making up the remaining 5%. This chapter discusses ovarian cancer and testicular cancer, including definitions of the diseases and their etiologies, typical symptoms, uncommon symptoms, demographics, natural history, complications, diagnostic approach, other diagnoses that should be considered, prognosis, and treatment.

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Nitrogen fractionation processes in germ cell tumours in the light of the most modern method of direct cancer tissue investigation

10.26226/morressier.5b4709846f4cb30010951b88 ◽

2018 ◽

Author(s):

Katarzyna Taran

Keyword(s):

Germ Cell ◽

Modern Method ◽

Cancer Tissue ◽

Germ Cell Tumours

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Faculty of 1000 evaluation for Regional deep hyperthermia for salvage treatment of children and adolescents with refractory or recurrent non-testicular malignant germ-cell tumours: an open-label, non-randomised, single-institution, phase 2 study.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718052125.793484801 ◽

2013 ◽

Author(s):

Steve Plaxe ◽

Kristy Ward

Keyword(s):

Germ Cell ◽

Children And Adolescents ◽

Salvage Treatment ◽

Germ Cell Tumours ◽

Phase 2 ◽

Single Institution ◽

Open Label ◽

Phase 2 Study ◽

Deep Hyperthermia

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Best practice for chronic oedema in community settings: what can we learn?

British Journal of Community Nursing ◽

10.12968/bjcn.2020.25.12.610 ◽

2020 ◽

Vol 25 (12) ◽

pp. 610-614

Author(s):

Garry Cooper-Stanton

Keyword(s):

Service Provision ◽

Best Practice ◽

Evidence Base ◽

Community Services ◽

Guidance Document ◽

Community Settings ◽

Tissue Viability ◽

Delivery Of Care ◽

Specialist Nurses ◽

The Uk

There are various opportunities and challenges in the delivery of care to those diagnosed with chronic oedema/lymphoedema. Service provision is not consistent within the UK, and non-specialist nurses and other health professionals may be called on to fill the gaps in this area. The latest best practice guidance on chronic oedema is directed at community services that care for people within their own homes in primary care. This guide was developed in order to increase awareness, knowledge and access to an evidence base. Those involved in its creation cross specialist fields (lymphoedema and tissue viability), resulting in the document covering a number of areas, including an explanation of chronic oedema, its assessment and management and the association between chronic oedema and wet legs. The document complements existing frameworks on the condition and its management and also increases the available tools within chronic oedema management in the community. The present article provides an overview of the guidance document and discusses its salient features.

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The Potential of Artificial Intelligence to Detect Lymphovascular Invasion in Testicular Cancer

Cancers ◽

10.3390/cancers13061325 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1325

Author(s):

Abhisek Ghosh ◽

Korsuk Sirinukunwattana ◽

Nasullah Khalid Alham ◽

Lisa Browning ◽

Richard Colling ◽

...

Keyword(s):

Artificial Intelligence ◽

Testicular Cancer ◽

Germ Cell ◽

Lymphovascular Invasion ◽

Automatic Segmentation ◽

Prognostic Significance ◽

Germ Cell Tumours ◽

Testicular Germ Cell ◽

Testicular Germ Cell Tumours ◽

Whole Slide Images

Testicular cancer is the most common cancer in men aged from 15 to 34 years. Lymphovascular invasion refers to the presence of tumours within endothelial-lined lymphatic or vascular channels, and has been shown to have prognostic significance in testicular germ cell tumours. In non-seminomatous tumours, lymphovascular invasion is the most powerful prognostic factor for stage 1 disease. For the pathologist, searching multiple slides for lymphovascular invasion can be highly time-consuming. The aim of this retrospective study was to develop and assess an artificial intelligence algorithm that can identify areas suspicious for lymphovascular invasion in histological digital whole slide images. Areas of possible lymphovascular invasion were annotated in a total of 184 whole slide images of haematoxylin and eosin (H&E) stained tissue from 19 patients with testicular germ cell tumours, including a mixture of seminoma and non-seminomatous cases. Following consensus review by specialist uropathologists, we trained a deep learning classifier for automatic segmentation of areas suspicious for lymphovascular invasion. The classifier identified 34 areas within a validation set of 118 whole slide images from 10 patients, each of which was reviewed by three expert pathologists to form a majority consensus. The precision was 0.68 for areas which were considered to be appropriate to flag, and 0.56 for areas considered to be definite lymphovascular invasion. An artificial intelligence tool which highlights areas of possible lymphovascular invasion to reporting pathologists, who then make a final judgement on its presence or absence, has been demonstrated as feasible in this proof-of-concept study. Further development is required before clinical deployment.

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