scholarly journals Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome

2020 ◽  
Vol 22 (5) ◽  
pp. 847-856 ◽  
Author(s):  
Mark Drost ◽  
Yvonne Tiersma ◽  
Dylan Glubb ◽  
Scott Kathe ◽  
Sandrine van Hees ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Lynch Syndrome

scholarly journals Interaction of Universal and Ethnocultural Codes in Structure of Advertisement Communication

2018 ◽  
Vol 50 ◽  
pp. 01206
Author(s):  
Elena N. Ezhova ◽  
Oksana A. Dvoenko
Keyword(s):  
Functional Analysis ◽  
Institutional Discourse ◽  
Multicultural Society ◽  
Ability To Work ◽  
Cultural Codes ◽  
The People ◽  
Semiotic Approach ◽  
Semiotic Systems ◽  
Advertising Information

This work presents the systematized Russian and foreign scientific knowledge about the specific functioning of advertisement discourse in multiethnic society. The methodology of this research is based on the structural semiotic approach, functional analysis, an institutional-discourse method, an activity approach. The analysis of a big number of advertisement texts served the basis for typological classification of ethno cultural codes in the structure of media advertisement communication. The idea of this typology is heterogeneity advertisement texts, which are organized on the basis of the three semiotic systems: visual, verbal and acoustic. The understanding and realization of the idea of hybrid text modeling in the advertisement design allows one to improve its effectiveness, which results from the increase of the level of advertising information perception and the degree of its impact to the people. This demonstrates the importance of such professional qualities for advertisement specialists as the readiness and ability to work in multicultural society.

The evolution of functional design in rudists (Hippuritacea) and its taxonomic implications

1978 ◽  
Vol 284 (1001) ◽  
pp. 305-318 ◽  
Keyword(s):  
Functional Analysis ◽  
Evolutionary Trends ◽  
Functional Design ◽  
Poor Understanding ◽  
Solid Foundation ◽  
Taxonomic Implications ◽  
Shell Geometry ◽  
Flexible Model

Poor understanding of rudist growth geometry and anatomy has hampered systematic studies of the superfamily. A flexible model that simulates the growth of rudist shells is therefore presented so that evolutionary trends in the group may be consistently analysed; this model is constructed by rotational or irrotational stacking of inclined gnomons around a contained axis. Functional analysis of shell geometry and reconstructed anatomy provides a more solid foundation for rudist systematics. The first rudists (Diceratidae) employed one or other of the spirogyrate umbones, inherited from megalodontid ancestors, as a facultatively elevating encrustation stem. Invagination of the ligament in the Caprotinidae permitted uncoiling of the shell, though this also entailed reduced gaping and therefore externalization of food entrapment, with increasing involvement of the mantle margins. Caprotinid functional design was preadapted to several new adaptive zones, which were exploited by various advanced descendant groups. Some of these groups show homeomorphic evolution and have often been assembled by earlier workers into polyphyletic ‘families’ (e.g. Caprinidae). An attempt is therefore made to establish a skeletal classification of rudists on the basis of true clades, as distinguished by careful functional analysis.

A putative Lynch syndrome family carrying MSH2 and MSH6 variants of uncertain significance—functional analysis reveals the pathogenic one

2011 ◽  
Vol 10 (3) ◽  
pp. 515-520 ◽  
Author(s):  
Jukka Kantelinen ◽  
Thomas v. O. Hansen ◽  
Minttu Kansikas ◽  
Lotte Nylandsted Krogh ◽  
Mari K. Korhonen ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Lynch Syndrome ◽  
Variants Of Uncertain Significance ◽  
Uncertain Significance ◽  
Lynch Syndrome Family

scholarly journals NATpare: a pipeline for high-throughput prediction and functional analysis of nat-siRNAs

2020 ◽  
Vol 48 (12) ◽  
pp. 6481-6490 ◽  
Author(s):  
Joshua Thody ◽  
Leighton Folkes ◽  
Vincent Moulton
Keyword(s):  
Functional Analysis ◽  
Messenger Rnas ◽  
Small Interfering Rnas ◽  
Sequencing Data ◽  
Software Pipeline ◽  
Resource Requirements ◽  
Time Required ◽  
First Time ◽  
Specific Mrna

Abstract Natural antisense transcript-derived small interfering RNAs (nat-siRNAs) are a class of functional small RNA (sRNA) that have been found in both plant and animals kingdoms. In plants, these sRNAs have been shown to suppress the translation of messenger RNAs (mRNAs) by directing the RNA-induced silencing complex (RISC) to their sequence-specific mRNA target(s). Current computational tools for classification of nat-siRNAs are limited in number and can be computationally infeasible to use. In addition, current methods do not provide any indication of the function of the predicted nat-siRNAs. Here, we present a new software pipeline, called NATpare, for prediction and functional analysis of nat-siRNAs using sRNA and degradome sequencing data. Based on our benchmarking in multiple plant species, NATpare substantially reduces the time required to perform prediction with minimal resource requirements allowing for comprehensive analysis of nat-siRNAs in larger and more complex organisms for the first time. We then exemplify the use of NATpare by identifying tissue and stress specific nat-siRNAs in multiple Arabidopsis thaliana datasets.

Functional analysis ofMSH2unclassified variants found in suspected Lynch syndrome patients reveals pathogenicity due to attenuated mismatch repair

2014 ◽  
Vol 51 (4) ◽  
pp. 245-253 ◽  
Author(s):  
Eva AL Wielders ◽  
Jan Hettinger ◽  
Rob Dekker ◽  
C Marleen Kets ◽  
Marjolijn J Ligtenberg ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Lynch Syndrome ◽  
Mismatch Repair

Elements of Geometry of Balls in Banach Spaces

2018 ◽  
Author(s):  
Kazimierz Goebel ◽  
Stanislaw Prus
Keyword(s):  
Functional Analysis ◽  
Graduate Students ◽  
Banach Spaces ◽  
Fixed Point Theory ◽  
Point Theory ◽  
Normed Spaces ◽  
The Subject ◽  
Basic Facts ◽  
Weak Topologies

One of the subjects of functional analysis is classification of Banach spaces depending on various properties of the unit ball. The need of such considerations comes from a number of applications to problems of mathematical analysis. The list of subjects contains: differential calculus in normed spaces, approximation theory, weak topologies and reflexivity, general theory of convexity and convex functions, metric fixed point theory, and others. The aim of this book is to present basic facts from this field. It is addressed to advanced undergraduate and graduate students interested in the subject. For some it may result in further interest, a continuation and deepening of their study of the subject. It may be also useful for instructors running courses on functional analysis, supervising diploma theses or essays on various levels.

Kinematic Structural and Functional Analysis of Wobble-Plate Engines

1986 ◽  
Vol 108 (2) ◽  
pp. 226-236 ◽  
Author(s):  
Z. Yu ◽  
Ting W. Lee
Keyword(s):  
Functional Analysis ◽  
Design Guidelines ◽  
Structure And Function ◽  
General Nature ◽  
Mathematical Approach ◽  
Type Synthesis ◽  
Optimization Criteria ◽  
Design Heuristics ◽  
And Function

This paper concerns the development of a procedure for systematic searching for mechanisms, classifying them, and screening for the optimum mechanism structure for wobble-plate engines. It includes two parts. The first part is on kinematic structural analysis, including the development of a procedure for the structure classification of 150 mechanisms obtained as a result of an exhaustive search from the prior arts, as disclosed in nearly 1000 patents between 1874 and 1982, and other publications. The second part is on functional analysis, which screens for an optimum design based on a set of judgment criteria. Such optimization criteria are developed in this paper and applied to a group of representative mechanisms derived from the structure analysis. Recommendations such as design guidelines are presented. The general nature of the approach—following the method of separation of kinematic structure and function [1] and combining mathematical approach and design heuristics—is demonstrated here in the case of wobble-plate engine mechanisms and is believed to be useful in type synthesis and design of mechanisms of realistic complexity.

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