scholarly journals Spiny mouse (Acomys): an emerging research organism for regenerative medicine with applications beyond the skin

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Janak Gaire ◽  
Justin A. Varholick ◽  
Sabhya Rana ◽  
Michael D. Sunshine ◽  
Sylvain Doré ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Human Diseases ◽  
Spiny Mouse ◽  
Skin Wounds ◽  
Wide Range ◽  
Regeneration Of Skin ◽  
Shed Light

AbstractThe spiny mouse (Acomys species) has emerged as an exciting research organism due to its remarkable ability to undergo scarless regeneration of skin wounds and ear punches. Excitingly, Acomys species demonstrate scar-free healing in a wide-range of tissues beyond the skin. In this perspective article, we discuss published findings from a variety of tissues to highlight how this emerging research organism could shed light on numerous clinically relevant human diseases. We also discuss the challenges of working with this emerging research organism and suggest strategies for future Acomys-inspired research.

scholarly journals The possibilities of stem cell application in regenerative medicine

2016 ◽  
Vol 54 (1) ◽  
pp. 49-64
Author(s):  
Sabina Galiniak ◽  
Izabela Krawczyk-Merć ◽  
Agnieszka Pedrycz
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Cell Types ◽  
Skin Damage ◽  
Wide Range ◽  
Bioethical Issues ◽  
The Subject ◽  
Alternative Sources ◽  
Regeneration Of Skin ◽  
Embryonal Stem

AbstractStem cells are characterized by their ability to self-renew and differentiate into various cell types. They offer great potential for a wide range of applications, however, medical studies on the use of embryonal stem cells are largely limited to bioethical issues searching for alternative sources of stem cells, which include isolating cells from adult organisms or inducing pluripotentiality of somatic cells by administration of transcription factors. Nowadays, stem cells are used to study the mechanisms of cell differentiation and treat diseases that are commonly considered to be incurable, such as diabetes and neurodegenerative diseases, as well as enable regeneration of skin damage and myocardium. This review introduces the subject of stem cells, their sources and application in regenerative medicine.

Sentence-Based Experience Logging in New Hearing Aid Users

2020 ◽  
Vol 29 (3S) ◽  
pp. 631-637
Author(s):  
Katja Lund ◽  
Rodrigo Ordoñez ◽  
Jens Bo Nielsen ◽  
Dorte Hammershøi
Keyword(s):  
Hearing Aid ◽  
Patient Experiences ◽  
Online Tool ◽  
Rehabilitation Process ◽  
Hearing Rehabilitation ◽  
Clinical Observations ◽  
Hearing Aid Use ◽  
Wide Range ◽  
Insight Into ◽  
Shed Light

Purpose The aim of this study was to develop a tool to gain insight into the daily experiences of new hearing aid users and to shed light on aspects of aided performance that may not be unveiled through standard questionnaires. Method The tool is developed based on clinical observations, patient experiences, expert involvement, and existing validated hearing rehabilitation questionnaires. Results An online tool for collecting data related to hearing aid use was developed. The tool is based on 453 prefabricated sentences representing experiences within 13 categories related to hearing aid use. Conclusions The tool has the potential to reflect a wide range of individual experiences with hearing aid use, including auditory and nonauditory aspects. These experiences may hold important knowledge for both the patient and the professional in the hearing rehabilitation process.

scholarly journals Stem cell therapies and benefaction of somatic cell nuclear transfer cloning in COVID-19 era

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Birbal Singh ◽  
Gorakh Mal ◽  
Vinod Verma ◽  
Ruchi Tiwari ◽  
Muhammad Imran Khan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Somatic Cell ◽  
Somatic Cell Nuclear Transfer ◽  
Nuclear Transfer ◽  
Drug Testing ◽  
Human Interaction ◽  
Patient Specific ◽  
Wide Range

Abstract Background The global health emergency of COVID-19 has necessitated the development of multiple therapeutic modalities including vaccinations, antivirals, anti-inflammatory, and cytoimmunotherapies, etc. COVID-19 patients suffer from damage to various organs and vascular structures, so they present multiple health crises. Mesenchymal stem cells (MSCs) are of interest to treat acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 infection. Main body Stem cell-based therapies have been verified for prospective benefits in copious preclinical and clinical studies. MSCs confer potential benefits to develop various cell types and organoids for studying virus-human interaction, drug testing, regenerative medicine, and immunomodulatory effects in COVID-19 patients. Apart from paving the ways to augment stem cell research and therapies, somatic cell nuclear transfer (SCNT) holds unique ability for a wide range of health applications such as patient-specific or isogenic cells for regenerative medicine and breeding transgenic animals for biomedical applications. Being a potent cell genome-reprogramming tool, the SCNT has increased prominence of recombinant therapeutics and cellular medicine in the current era of COVID-19. As SCNT is used to generate patient-specific stem cells, it avoids dependence on embryos to obtain stem cells. Conclusions The nuclear transfer cloning, being an ideal tool to generate cloned embryos, and the embryonic stem cells will boost drug testing and cellular medicine in COVID-19.

scholarly journals Beyond cultural and geographical proximity: delving into the factors that influence the dynamics of academic relationships between students in higher education

2021 ◽  
Author(s):  
José-Vicente Tomás-Miquel ◽  
Jordi Capó-Vicedo
Keyword(s):  
University Students ◽  
Academic Research ◽  
Past Research ◽  
Academic Networks ◽  
Level Data ◽  
Wide Range ◽  
Specific Stage ◽  
The University ◽  
Proximity Dimensions ◽  
Shed Light

AbstractScholars have widely recognised the importance of academic relationships between students at the university. While much of the past research has focused on studying their influence on different aspects such as the students’ academic performance or their emotional stability, less is known about their dynamics and the factors that influence the formation and dissolution of linkages between university students in academic networks. In this paper, we try to shed light on this issue by exploring through stochastic actor-oriented models and student-level data the influence that a set of proximity factors may have on formation of these relationships over the entire period in which students are enrolled at the university. Our findings confirm that the establishment of academic relationships is derived, in part, from a wide range of proximity dimensions of a social, personal, geographical, cultural and academic nature. Furthermore, and unlike previous studies, this research also empirically confirms that the specific stage in which the student is at the university determines the influence of these proximity factors on the dynamics of academic relationships. In this regard, beyond cultural and geographic proximities that only influence the first years at the university, students shape their relationships as they progress in their studies from similarities in more strategic aspects such as academic and personal closeness. These results may have significant implications for both academic research and university policies.

scholarly journals Messianism, rationalism and inter-Asian connections: The Majalis-i Jahangiri (1608–11) and the socio-intellectual history of the Mughal ‘ulama

2017 ◽  
Vol 54 (3) ◽  
pp. 317-338 ◽  
Author(s):  
Corinne Lefèvre
Keyword(s):  
Central Asia ◽  
Intellectual History ◽  
State Building ◽  
Specific Role ◽  
Wide Range ◽  
History Of ◽  
Muslim Intellectuals ◽  
Shed Light

Relying on the Majalis-i Jahangiri (1608–11) by ʿAbd al-Sattar b. Qasim Lahauri, this essay explores some of the discussions the Mughal Emperor Jahangir (r. 1605–27) conducted with a wide range of scholars, from Brahmans and ʿulama to Jesuit padres and Jewish savants. By far the most numerous, the debates bearing on Islam and involving Muslim intellectuals are especially significant on several accounts. First, because they illuminate how, following in the steps of his father Akbar (r. 1556–605), Jahangir was able to conciliate his messianic claims with a strong engagement with reason and to turn this combination into a formidable instrument for confession and state building. These conversations also provide promising avenues to think afresh the socio-intellectual history of the Mughal ʿulama inasmuch as they capture the challenges and adjustments attendant on imperial patronage, depict the jockeying for influence and positions among intellectuals (particularly between Indo-Muslim and Iranian lettrés), and shed light on relatively little known figures or on unexplored facets of more prominent individuals. In addition, the specific role played by scholars hailing from Iran—and, to a lesser extent, from Central Asia—in the juridical-religious disputes of the Indian court shows how crucial inter-Asian connections and networks were in the fashioning of Mughal ideology but also the ways in which the ongoing flow of émigré ʿulama was disciplined before being incorporated into the empire.

scholarly journals A new lead to NLRP3 inhibition

2017 ◽  
Vol 214 (11) ◽  
pp. 3147-3149 ◽  
Author(s):  
Mohamed Lamkanfi ◽  
Vishva M. Dixit
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Therapeutic Benefit ◽  
Human Diseases ◽  
Molecule Inhibitor ◽  
Wide Range ◽  
Potential Therapeutic Benefit

The discovery of a small molecule inhibitor that targets the inflammasome sensor NLRP3 offers a new path for the development of selective inflammasome blockers with potential therapeutic benefit in a wide range of human diseases (in this issue, see Jiang et al., https://doi.org/10.1084/jem.20171419).

scholarly journals Book Review: Islam: A Worldwide Encyclopedia

2017 ◽  
Vol 57 (2) ◽  
pp. 151
Author(s):  
Paul Fehrmann
Keyword(s):  
International Law ◽  
Common Ground ◽  
Controversial Issues ◽  
Islamic Studies ◽  
Law And Politics ◽  
Wide Range ◽  
Senior Researcher ◽  
Shed Light ◽  
Academic Debate

It is clear that the world of Islam is profoundly important, and also that there are wide and conflicting views on Islam today. Similarly, it seems clear that we should pursue efforts to promote the understanding of Islam. In response, a goal of the four volume Islam: A Worldwide Encyclopedia (IAWE) is to give “basic information on Islam” and to “shed light” on “controversial issues” (xxvii). In his opening comments, the editor, a Professor of International Law and Politics at Eskişehir Osmangazi University and Senior Researcher at the Wise Men Center for Strategic Research in Turkey, notes that there have been “a wide range of different interpretations and variations of Islam throughout history” (xxvii). He suggests that Muslims need to revive the “strong tradition of academic debate” that was integral to Islamic studies “in early decades of Islam,” and affirms support for the “diverse and plural nature of contemporary Islamic scholarship” (xxviii). At the same time, he is concerned that “disputed issues” may lead to “biases and stereotypes in the minds of Western people,” and hopes that this new resource can both “contribute to the pursuit of a common ground” between those of different faiths, and help a Western audience become more familiar with what Islam has to offer (xxviii).

scholarly journals Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Wide Range ◽  
Potential Applications ◽  
Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

scholarly journals Ceramics as the conveyance of art

2017 ◽  
Vol 6 (4) ◽  
pp. 133-139
Author(s):  
Olcay Boratav
Keyword(s):  
Time Perspective ◽  
Background Knowledge ◽  
Original Structure ◽  
The Arts ◽  
Art Form ◽  
Wide Range ◽  
Different Shapes ◽  
Different Cultures ◽  
Greek Pottery ◽  
Shed Light

AbstractThe concept of art has varied according to space and time perspective in each and every period and it has emerged in different forms in every culture. Artists or designers produce a wide range of forms with different materials representing the period and culture while creating their ceramics. Ceramics symbolizes a thousand-year-old endeavor as well as being considered as one of the arts. It has shed light on the history in different shapes and cultures in addition to undertaking the task of conveyance of art with original structure and formal style in the works of art. Ceramics makes identity differences thanks to background knowledge, form and decorative techniques and originality. Art is not for society’s sake; it aims to relieve the tension, to satisfy pleasure, to enable people to see and hear, to use and to evaluate. Different cultures have generated new styles in their ceramics by integrating creativity into their own traditions and techniques as well as interacting with Mayan vases and pots, Greek pottery, Anatolian ceramics and tiles. Some of these impacts have been so profound in ceramics that they have been passed on from generation to generation.This paper seeks to address to the following questions: How was ceramics used in different cultures and periods with composition features such as form, decoration, motif and figure; and how has it undertaken the task of conveyance of art by investigating what features they have. Keywords: ceramics, art, conveyance of art, form, figure.

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