scholarly journals Circadian clocks guide dendritic cells into skin lymphatics

2021 ◽  
Author(s):  
Stephan J. Holtkamp ◽  
Louise M. Ince ◽  
Coline Barnoud ◽  
Madeleine T. Schmitt ◽  
Flore Sinturel ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Lymphatic Vessels ◽  
Migration Pattern ◽  
Circadian Clocks ◽  
Leukocyte Trafficking ◽  
Lymphatic Endothelial Cells ◽  
Cell Type ◽  
Adaptive Immune Responses ◽  
Adaptive Immune

AbstractMigration of leukocytes from the skin to lymph nodes (LNs) via afferent lymphatic vessels (LVs) is pivotal for adaptive immune responses1,2. Circadian rhythms have emerged as important regulators of leukocyte trafficking to LNs via the blood3,4. Here, we demonstrate that dendritic cells (DCs) have a circadian migration pattern into LVs, which peaks during the rest phase in mice. This migration pattern is determined by rhythmic gradients in the expression of the chemokine CCL21 and of adhesion molecules in both mice and humans. Chronopharmacological targeting of the involved factors abrogates circadian migration of DCs. We identify cell-intrinsic circadian oscillations in skin lymphatic endothelial cells (LECs) and DCs that cogovern these rhythms, as their genetic disruption in either cell type ablates circadian trafficking. These observations indicate that circadian clocks control the infiltration of DCs into skin lymphatics, a process that is essential for many adaptive immune responses and relevant for vaccination and immunotherapies.

scholarly journals CD8+lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury

2017 ◽  
Vol 27 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Rituparna Chakraborty ◽  
Janin Chandra ◽  
Shuai Cui ◽  
Lynn Tolley ◽  
Matthew A. Cooper ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Inflammasome Activation ◽  
Adaptive Immune Responses ◽  
Skin Injury ◽  
Adaptive Immune

scholarly journals Dendritic Cells in Innate and Adaptive Immune Responses against Influenza Virus

Viruses ◽  
2009 ◽  
Vol 1 (3) ◽  
pp. 1022-1034 ◽  
Author(s):  
Artur Summerfield ◽  
Kenneth McCullough
Keyword(s):  
Dendritic Cells ◽  
Influenza Virus ◽  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Adaptive Immune

scholarly journals Dendritic Cells/Macrophages-Targeting Feature of Ebola Glycoprotein and its Potential as Immunological Facilitator for Antiviral Vaccine Approach

2019 ◽  
Vol 7 (10) ◽  
pp. 402
Author(s):  
Titus Abiola Olukitibi ◽  
Zhujun Ao ◽  
Mona Mahmoudi ◽  
Gary A. Kobinger ◽  
Xiaojian Yao
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Ebola Virus ◽  
Vaccine Development ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Immunological Approach ◽  
Vaccine Approach ◽  
Acquired Immune Responses ◽  
Diverse Virus

In the prevention of epidemic and pandemic viral infection, the use of the antiviral vaccine has been the most successful biotechnological and biomedical approach. In recent times, vaccine development studies have focused on recruiting and targeting immunogens to dendritic cells (DCs) and macrophages to induce innate and adaptive immune responses. Interestingly, Ebola virus (EBOV) glycoprotein (GP) has a strong binding affinity with DCs and macrophages. Shreds of evidence have also shown that the interaction between EBOV GP with DCs and macrophages leads to massive recruitment of DCs and macrophages capable of regulating innate and adaptive immune responses. Therefore, studies for the development of vaccine can utilize the affinity between EBOV GP and DCs/macrophages as a novel immunological approach to induce both innate and acquired immune responses. In this review, we will discuss the unique features of EBOV GP to target the DC, and its potential to elicit strong immune responses while targeting DCs/macrophages. This review hopes to suggest and stimulate thoughts of developing a stronger and effective DC-targeting vaccine for diverse virus infection using EBOV GP.

scholarly journals Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis

Genes ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 323 ◽  
Author(s):  
Guoying Wang ◽  
Xianghui Li ◽  
Lei Zhang ◽  
Abualgasim Elgaili Abdalla ◽  
Tieshan Teng ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Immune Responses ◽  
Critical Role ◽  
Innate Immune ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Th2 Responses ◽  
Novel Strategy

Dendritic cells (DCs) play a critical role in the immune system which sense pathogens and present their antigens to prime the adaptive immune responses. As the progression of sepsis occurs, DCs are capable of orchestrating the aberrant innate immune response by sustaining the Th1/Th2 responses that are essential for host survival. Hence, an in-depth understanding of the characteristics of DCs would have a beneficial effect in overcoming the obstacle occurring in sepsis. This paper focuses on the role of DCs in the progression of sepsis and we also discuss the reverse sepsis-induced immunosuppression through manipulating the DC function. In addition, we highlight some potent immunotherapies that could be used as a novel strategy in the early treatment of sepsis.

Dendritic cells and C‐type lectin receptors: coupling innate to adaptive immune responses

2008 ◽  
Vol 86 (7) ◽  
pp. 580-587 ◽  
Author(s):  
Sandra J Vliet ◽  
Juan J García‐Vallejo ◽  
Yvette Kooyk
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Lectin Receptors ◽  
Adaptive Immune

scholarly journals Specialized Proresolving Mediators in Innate and Adaptive Immune Responses in Airway Diseases

2018 ◽  
Vol 98 (3) ◽  
pp. 1335-1370 ◽  
Author(s):  
Nandini Krishnamoorthy ◽  
Raja-Elie E. Abdulnour ◽  
Katherine H. Walker ◽  
Braden D. Engstrom ◽  
Bruce D. Levy
Keyword(s):  
Immune Responses ◽  
Dynamic Process ◽  
Cell Type ◽  
Organ Function ◽  
Cellular Mechanisms ◽  
Adaptive Immune Responses ◽  
Disease Pathogenesis ◽  
Adaptive Immune ◽  
Airway Diseases ◽  
Cell Type Specific

Airborne pathogens and environmental stimuli evoke immune responses in the lung. It is critical to health that these responses be controlled to prevent tissue damage and the compromise of organ function. Resolution of inflammation is a dynamic process that is coordinated by biochemical and cellular mechanisms. Recently, specialized proresolving mediators (SPMs) have been identified in resolution exudates. These molecules orchestrate anti-inflammatory and proresolving actions that are cell type specific. In this review, we highlight SPM biosynthesis, the influence of SPMs on the innate and adaptive immune responses in the lung, as well as recent insights from SPMs on inflammatory disease pathophysiology. Uncovering these mediators and cellular mechanisms for resolution is providing new windows into physiology and disease pathogenesis.

scholarly journals Inducible Expression of Stat4 in Dendritic Cells and Macrophages and Its Critical Role in Innate and Adaptive Immune Responses

2001 ◽  
Vol 166 (7) ◽  
pp. 4446-4455 ◽  
Author(s):  
Taro Fukao ◽  
David M. Frucht ◽  
George Yap ◽  
Massimo Gadina ◽  
John J. O’Shea ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Critical Role ◽  
Inducible Expression ◽  
Adaptive Immune Responses ◽  
Adaptive Immune
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