scholarly journals Crucial role of 4-deoxy-L-erythro-5-hexoseulose uronate reductase for alginate utilization revealed by adaptive evolution in engineered Saccharomyces cerevisiae

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Fumiya Matsuoka ◽  
Makoto Hirayama ◽  
Takayuki Kashihara ◽  
Hideki Tanaka ◽  
Wataru Hashimoto ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Adaptive Evolution ◽  
Crucial Role ◽  
Engineered Saccharomyces Cerevisiae

The role of peroxisomes in xylose alcoholic fermentation in the engineered Saccharomyces cerevisiae

2020 ◽  
Vol 44 (8) ◽  
pp. 1606-1615 ◽  
Author(s):  
Ljubov Dzanaeva ◽  
Barbara Kruk ◽  
Justyna Ruchala ◽  
Jens Nielsen ◽  
Andriy Sibirny ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Alcoholic Fermentation ◽  
Engineered Saccharomyces Cerevisiae

scholarly journals A Regulatory Role of the Rnq1 Nonprion Domain for Prion Propagation and Polyglutamine Aggregates

2008 ◽  
Vol 28 (10) ◽  
pp. 3313-3323 ◽  
Author(s):  
Hiroshi Kurahashi ◽  
Masao Ishiwata ◽  
Shoichiro Shibata ◽  
Yoshikazu Nakamura
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Sodium Dodecyl Sulfate ◽  
Crucial Role ◽  
De Novo ◽  
Self Regulation ◽  
Sodium Dodecyl ◽  
Protein Conformations ◽  
Chaperone Protein ◽  
Prion Propagation

ABSTRACT Prions are infectious, self-propagating protein conformations. Rnq1 is required for the yeast Saccharomyces cerevisiae prion [PIN +], which is necessary for the de novo induction of a second prion, [PSI +]. Here we isolated a [PSI +]-eliminating mutant, Rnq1Δ100, that deletes the nonprion domain of Rnq1. Rnq1Δ100 inhibits not only [PSI +] prion propagation but also [URE3] prion and huntingtin's polyglutamine aggregate propagation in a [PIN +] background but not in a [pin −] background. Rnq1Δ100, however, does not eliminate [PIN +]. These findings are interpreted as showing a possible involvement of the Rnq1 prion in the maintenance of heterologous prions and polyQ aggregates. Rnq1 and Rnq1Δ100 form a sodium dodecyl sulfate-stable and Sis1 (an Hsp40 chaperone protein)-containing coaggregate in [PIN +] cells. Importantly, Rnq1Δ100 is highly QN-rich and prone to self-aggregate or coaggregate with Rnq1 when coexpressed in [pin −] cells. However, the [pin −] Rnq1-Rnq1Δ100 coaggregate does not represent a prion-like aggregate. These findings suggest that [PIN +] Rnq1-Rnq1Δ100 aggregates interact with other transmissible and nontransmissible amyloids to destabilize them and that the nonprion domain of Rnq1 plays a crucial role in self-regulation of the highly reactive QN-rich prion domain of Rnq1.

scholarly journals Saccharomyces cerevisiae, a Powerful Model for Studying rRNA Modifications and Their Effects on Translation Fidelity

2021 ◽  
Vol 22 (14) ◽  
pp. 7419
Author(s):  
Agnès Baudin-Baillieu ◽  
Olivier Namy
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Amino Acids ◽  
Ribosomal Rna ◽  
Crucial Role ◽  
Peptide Bond ◽  
Heterogeneous Population ◽  
Chemical Modifications ◽  
Yeast Saccharomyces Cerevisiae ◽  
Translation Fidelity

Ribosomal RNA is a major component of the ribosome. This RNA plays a crucial role in ribosome functioning by ensuring the formation of the peptide bond between amino acids and the accurate decoding of the genetic code. The rRNA carries many chemical modifications that participate in its maturation, the formation of the ribosome and its functioning. In this review, we present the different modifications and how they are deposited on the rRNA. We also describe the most recent results showing that the modified positions are not 100% modified, which creates a heterogeneous population of ribosomes. This gave rise to the concept of specialized ribosomes that we discuss. The knowledge accumulated in the yeast Saccharomyces cerevisiae is very helpful to better understand the role of rRNA modifications in humans, especially in ribosomopathies.

Epitaxial YBa2Cu3O7-8 films : Crucial role of growth-induced linear defects in microwave properties

2001 ◽  
Vol 11 (PR11) ◽  
pp. Pr11-47-Pr11-52
Author(s):  
V. M. Pan ◽  
V. S. Flis ◽  
V. A. Komashko ◽  
O. G. Plys ◽  
C. G. Tretiatchenko ◽  
...  
Keyword(s):  
Crucial Role ◽  
Microwave Properties ◽  
Linear Defects

ANALISIS YURIDIS PUTUSAN PENGADILAN NEGERI BLORA TENTANG DUALISME KEPENGURUSAN YAYASAN PENDIDIKAN ISLAM KARTAYUDA YANG AKTA PENDIRIANNYA DIBUAT OLEH DAN DIHADAPAN NOTARIS (Studi Kasus Putusan Perkara PN Blora No. 34/Pdt.G/2015/PN.Bla)

Jurnal Akta ◽  
2017 ◽  
Vol 4 (3) ◽  
pp. 463
Author(s):  
Muslim Ansori ◽  
Akhmad Khisni
Keyword(s):  
Private Schools ◽  
Education System ◽  
Crucial Role ◽  
The State ◽  
Educational Institutions ◽  
Legal Entity ◽  
Non Profit ◽  
The Right

With the enactment of the Education System Act no 20 of 2003 (better known as the Sisdiknas Act), the State has determined that educational institutions should have a legal umbrella in the form of a legal entity, or better known as the Legal Entity Education. As a non-profit organization, the Foundation is the right legal entity that becomes a place for educational institutions, especially private schools. Therefore, of course, Notary has a very crucial role in making notary deed in the form of establishment and deed of change, such as example how in making the right basic budget and not multi interpresatasi for stake holders in the foundation. Therefore, the role of function and authority of the organ of the foundation must be clearly stated in the articles of association, so as not to cause a dispute in the future.KEYWORDS: Notaries, Foundation, Organ Foundation,

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