scholarly journals Sclerostin antibody stimulates periodontal regeneration in large alveolar bone defects

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yao Yao ◽  
Frederic Kauffmann ◽  
Shogo Maekawa ◽  
Lea V. Sarment ◽  
James V. Sugai ◽  
...  
Keyword(s):  
Targeted Drug Delivery ◽  
Low Dose ◽  
Alveolar Bone ◽  
Tumor Resection ◽  
Periodontal Regeneration ◽  
Neutralizing Antibody ◽  
Bone Defects ◽  
Dose Delivery ◽  
Osseous Defects ◽  
Sclerostin Antibody

Abstract Destruction of the alveolar bone in the jaws can occur due to periodontitis, trauma or following tumor resection. Common reconstructive therapy can include the use of bone grafts with limited predictability and efficacy. Romosozumab, approved by the FDA in 2019, is a humanized sclerostin-neutralizing antibody (Scl-Ab) indicated in postmenopausal women with osteoporosis at high risk for fracture. Preclinical models show that Scl-Ab administration preserves bone volume during periodontal disease, repairs bone defects surrounding dental implants, and reverses alveolar bone loss following extraction socket remodeling. To date, there are no studies evaluating Scl-Ab to repair osseous defects around teeth or to identify the efficacy of locally-delivered Scl-Ab for targeted drug delivery. In this investigation, the use of systemically-delivered versus low dose locally-delivered Scl-Ab via poly(lactic-co-glycolic) acid (PLGA) microspheres (MSs) was compared at experimentally-created alveolar bone defects in rats. Systemic Scl-Ab administration improved bone regeneration and tended to increase cementogenesis measured by histology and microcomputed tomography, while Scl-Ab delivered by MSs did not result in enhancements in bone or cemental repair compared to MSs alone or control. In conclusion, systemic administration of Scl-Ab promotes bone and cemental regeneration while local, low dose delivery did not heal periodontal osseous defects in this study.

Effect of Nano Biphasic Calcium Phosphate Bioceramics on Periodontal Regeneration in the Treatment of Alveolar Defects

2012 ◽  
Vol 486 ◽  
pp. 422-425 ◽  
Author(s):  
Lan Lei Wang ◽  
Ji Hua Li ◽  
Yong Tao Xie ◽  
Pi Shan Yang ◽  
Yun Mao Liao ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Alveolar Bone ◽  
Periodontal Regeneration ◽  
Bone Defects ◽  
Beagle Dogs ◽  
Control Groups ◽  
Negative Controls ◽  
Osseous Defects ◽  
Positive Controls

The aim of the present study is to investigate the efficacy of nanobiphasic calcium phosphate (nanoBCP) bioceramic in the treatment of periodontal osseous defects. Alveolar bone defects were surgically created bilaterally at the buccal aspects of four second premolars in two beagle dogs. After root leveling, nanoBCP was randomly filled in one defect and nothing was put into the contralateral defect as negative controls. Bioglass was randomly filled in one of left defect as positive controls and nothing was put into the contralateral defect as negative controls. Dogs were killed at the 12th week. Histological observations were processed through a light microscopy. The results reveal that a great amount of functional periodontal fissures formed in the defects in the nanoBCP groups and bioglass groups while no new bone formed in the control groups at all. In this study, nanoBCP has proven to work well as a biocompatible and bioactive material to promote periodontal regeneration effectively.

scholarly journals Regeneration of Furcation Defects Treated with Porous Hydroxyapatite and Platelet-Rich Plasma: A Histological Study

2020 ◽  
Vol 10 (02) ◽  
pp. 68-73
Author(s):  
Avaneendra Talwar ◽  
Reshma Amin
Keyword(s):  
Growth Factor ◽  
Bone Formation ◽  
Transforming Growth Factor ◽  
Alveolar Bone ◽  
Platelet Rich Plasma ◽  
Periodontal Diseases ◽  
Histological Study ◽  
Periodontal Regeneration ◽  
Furcation Defects ◽  
Osseous Defects

Abstract Introduction The alveolar bone, periodontal ligament (PDL), and cementum are the integral structural components invariably subject to changes during periodontal diseases. Many documents on animal and human studies state that the polypeptide growth factors (GFs) have a role in periodontal regeneration. The platelet-rich fibrin (PRF) is in use since the last decade. It has the potential of delivering GFs into vertical osseous defects. Human platelets contain platelet-derived growth factor and transforming growth factor-β in their α granules. These GFs are involved in wound healing and act as promoters of tissue regeneration. The study aimed to obtain histologic evidence, if any, of new attachment in humans, following treatment of osseous defects with 10-1055-s-0040-1714651_00084_ (HA) and PRF mix. Materials and Methods Five maxillary molar teeth with advanced bone loss were treated with porous 10-1055-s-0040-1714651_00084_ (PHA) mixed with PRF. Distobuccal roots were resected and studied histologically for evidence of bone formation, if any, at 1st, 3rd, and the 5th months. Results The PHA was completely resorbed in all the specimens. There was definitive evidence of bone formation at the 3rd month itself with mature lamellar bone with resting and reversal lines at the fifth postoperative month. There was no evidence of new cementum or PDL formation. Conclusion PRF in conjunction with osteoconductive materials prove to accelerate bone formation in vertical osseous defects.

scholarly journals Periodontal regeneration capacity of equine particulate bone in canine alveolar bone defects

2010 ◽  
Vol 40 (5) ◽  
pp. 220 ◽  
Author(s):  
Tae-Il Kim ◽  
Chong-Pyoung Chung ◽  
Min-Suk Heo ◽  
Yoon-Jeong Park ◽  
Sang-Hoon Rhee
Keyword(s):  
Alveolar Bone ◽  
Periodontal Regeneration ◽  
Bone Defects ◽  
Regeneration Capacity

Therapy and regeneration-combined bone cements for minimally invasive treatment of neoplastic bone defects

2021 ◽  
Author(s):  
Yu Qu ◽  
Hui Zhuang ◽  
Meng Zhang ◽  
Yufeng Wang ◽  
Dong Zhai ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Minimally Invasive ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Tumor Resection ◽  
Bone Defects ◽  
Bone Cements ◽  
Invasive Treatment ◽  
Calcium Phosphate Cements ◽  
Bone Tumor Resection

Although calcium phosphate cements (CPC) have been clinically used to repair bone defects caused by bone tumor resection, traditional CPC cannot kill the remaining tumor cells after surgery and prevent...

scholarly journals A Graded Multifunctional Hybrid Scaffold with Superparamagnetic Ability for Periodontal Regeneration

2018 ◽  
Vol 19 (11) ◽  
pp. 3604 ◽  
Author(s):  
Simone Sprio ◽  
Elisabetta Campodoni ◽  
Monica Sandri ◽  
Lorenzo Preti ◽  
Tobias Keppler ◽  
...  
Keyword(s):  
Cell Fate ◽  
Alveolar Bone ◽  
Tape Casting ◽  
Periodontal Regeneration ◽  
Dental Tissue ◽  
Hybrid Scaffold ◽  
Dental Tissues ◽  
Biomineralization Process ◽  
Direct Cell

The regeneration of dental tissues is a still an unmet clinical need; in fact, no therapies have been completely successful in regenerating dental tissue complexes such as periodontium, which is also due to the lack of scaffolds that are able to guide and direct cell fate towards the reconstruction of different mineralized and non-mineralized dental tissues. In this respect, the present work develops a novel multifunctional hybrid scaffold recapitulating the different features of alveolar bone, periodontal ligament, and cementum by integrating the biomineralization process, and tape casting and electrospinning techniques. The scaffold is endowed with a superparamagnetic ability, thanks to the use of a biocompatible, bioactive superparamagnetic apatite phase, as a mineral component that is able to promote osteogenesis and to be activated by remote magnetic signals. The periodontal scaffold was obtained by engineering three different layers, recapitulating the relevant compositional and microstructural features of the target tissues, into a monolithic multifunctional graded device. Physico-chemical, morphological, and ultrastructural analyses, in association with preliminary in vitro investigations carried out with mesenchymal stem cells, confirm that the final scaffold exhibits a good mimicry of the periodontal tissue complex, with excellent cytocompatibility and cell viability, making it very promising for regenerative applications in dentistry.

scholarly journals Current approach to bone augmentation with allogeneic cortical graft: A case report

2021 ◽  
Vol 11 (Suppl. 1) ◽  
pp. 299-302
Author(s):  
Utku Nezih Yılmaz ◽  
Fatma Eriş Derkuş
Keyword(s):  
Case Report ◽  
Dental Implant ◽  
Soft Tissues ◽  
Alveolar Bone ◽  
Healing Process ◽  
Bone Defects ◽  
Current Approach ◽  
Autogenous Bone ◽  
Bone Augmentation ◽  
Alveolar Crest

Aim: Today, dental implant applications have become the most preferred option in the treatment of tooth deficiencies. Long-term successful results in dental implant applications depend largely on the volume and quality of the hard and soft tissues in the relevant region. Insufficient soft tissues and alveolar crest resorption complicate implant applications. Grafts and additional surgical procedures are required to compensate for resorption and to provide bone augmentation. Shell technique, one of the augmentation methods used in the treatment of alveolar bone defects, is an important procedure for guided bone regeneration. The purpose of this case report is to describe the treatment of vertical and horizontal bone loss with the Shell technique using allogeneic cortical grafts. Methodology: A 58-year-old female patient without any systemic disease was admitted to our clinic with the complaint of tooth loss in the right posterior mandibular region. In the intraoral and radiological examinations, it was determined that the bone volume in the relevant region was not sufficient for dental implant. Two-stage surgical treatment was planned for the patient. First, vertical and horizontal bone defects were augmented with allogeneic cortical graft application under local anesthesia. After the healing process, dental implants were placed in the sufficient volume of the alveolar bone and the patient's treatment was completed. Conclusion: Allogeneic grafts in the treatment of alveolar crest defects; it is a good alternative to autogenous bone grafts,there is no need for a second surgical field and the resulting reduction in morbidity.   How to cite this article: Eriş Derkuş F, Yılmaz UN. Current approach to bone augmentation with allogeneic cortical graft: A case report. Int Dent Res 2021;11(Suppl.1):299-302. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.44     Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

scholarly journals Periodontal disease defects and mandibular cortical index in lupus patients

2019 ◽  
Vol 22 (4) ◽  
pp. 506-512
Author(s):  
Vagner Braga ◽  
Lucas Morita ◽  
Luciana Munhoz ◽  
Silvia Lourenço ◽  
Emiko Arita
Keyword(s):  
Regression Analysis ◽  
Bone Loss ◽  
Periodontal Disease ◽  
Lupus Erythematosus ◽  
Alveolar Bone ◽  
Bone Defects ◽  
Panoramic Radiographs ◽  
Cortical Index ◽  
Multiple Organs ◽  
Mandibular Cortical Index

Objective:Systemic lupus erythematosus is an autoimmune disease that affects multiple organs. It is well known that lupus patients have higher risk of osteoporosis, but if the disease affects mandibular cortical bone and alveolar bone is not fully established. The objective of this study was to evaluate periodontal disease defects and mandibular osteoporotic alterations in patients with lupus as compared to healthy patients using panoramic radiographs.Material and Methods:The panoramic radiographs of 72 patients with lupus and 360 healthy patients were evaluated for the presence of bone loss secondary to periodontal disease, classified as horizontal and vertical bone loss. We also assessed mandibular osteoporotic alterations by using the mandibular cortical index. Logistic regression analysis was applied to estimate the risk of mandibular osteoporotic alterations as well as horizontal and vertical bone loss in patients with lupus as compared to healthy patients.Results:There were no statistically significant differences between groups in the presence of horizontal bone defects and mandibular cortical indexes. However, patients with lupus demonstrated that patients with lupus were 2.17 more likely to present vertical bone loss than healthy patients.Conclusions:Patients with lupus might have higher risk of vertical bone loss than healthy patients due to pathophysiology of their disease. Further larger prospective studies should be performed to confirm our findings.

scholarly journals Effect of Electrical Current on the Osteogenesis in Alveolar Bone Defects : Application of Tricalcium Phosphate

1987 ◽  
Vol 41 (5) ◽  
pp. 985-993 ◽  
Author(s):  
Kohzoh Kubota ◽  
Masatoshi Hitaka ◽  
Kazuo Yasumoto ◽  
Takashi Hayashikawa ◽  
Shinichi Umezaki ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Alveolar Bone ◽  
Electrical Current ◽  
Bone Defects

scholarly journals The possibility of healing alveolar bone defects with simvastatin thermosensitive gel: in vitro/in vivo evaluation

2018 ◽  
Vol Volume 12 ◽  
pp. 1997-2003 ◽  
Author(s):  
Hong Ruan ◽  
Youcheng Yu ◽  
Xuehua Guo ◽  
Qian Jiang ◽  
Ying Luo
Keyword(s):  
Alveolar Bone ◽  
Bone Defects ◽  
In Vivo Evaluation ◽  
Thermosensitive Gel

Custom Repair of Mandibular Bone Defects with 3D Printed Bioceramic Scaffolds

2017 ◽  
Vol 97 (1) ◽  
pp. 68-76 ◽  
Author(s):  
H. Shao ◽  
M. Sun ◽  
F. Zhang ◽  
A. Liu ◽  
Y. He ◽  
...  
Keyword(s):  
Weight Loss ◽  
Alveolar Bone ◽  
Bone Defects ◽  
Linear Shrinkage ◽  
Tris Buffer ◽  
Bone Tissue Regeneration ◽  
3 Dimensional ◽  
Flexural Resistance

Implanting artificial biomaterial implants into alveolar bone defects with individual shape and appropriate mechanical strength is still a challenge. In this study, bioceramic scaffolds, which can precisely match the mandibular defects in macro and micro, were manufactured by the 3-dimensional (3D) printing technique according to the computed tomography (CT) image. To evaluate the stimulatory effect of the material substrate on bone tissue regeneration in situ in a rabbit mandibular alveolar bone defect model, implants made with the newly developed, mechanically strong ~10% Mg-substituted wollastonite (Ca90%Mg10%SiO3; CSi-Mg10) were fabricated, implanted into the bone defects, and compared with implants made with the typical Ca-phosphate and Ca-silicate porous bioceramics, such as β-tricalcium phosphate (TCP), wollastonite (CaSiO3; CSi), and bredigite (Bred). The initial physicochemical tests indicated that although the CSi-Mg10 scaffolds had the largest pore dimension, they had the lowest porosity mainly due to the significant linear shrinkage of the scaffolds during sintering. Compared with the sparingly dissolvable TCP scaffolds (~2% weight loss) and superfast dissolvable (in Tris buffer within 6 wk) pure CSi and Bred scaffolds (~12% and ~14% weight loss, respectively), the CSi-Mg10 exhibited a mild in vitro biodissolution and moderate weight loss of ~7%. In addition, the CSi-Mg10 scaffolds showed a considerable initial flexural strength (31 MPa) and maintained very high flexural resistance during soaking in Tris buffer. The in vivo results revealed that the CSi-Mg10 scaffolds have markedly higher osteogenic capability than those on the TCP, CSi, and Bred scaffolds after 16 wk. These results suggest a promising potential application of customized CSi-Mg10 3D robocast scaffolds in the clinic, especially for repair of alveolar bone defects.

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