scholarly journals Influence of surfactant-tailored Mn-doped ZnO nanoparticles on ROS production and DNA damage induced in murine fibroblast cells

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Traian Popescu ◽  
Christien Oktaviani Matei ◽  
Ioana Dorina Vlaicu ◽  
Ioan Tivig ◽  
Andrei Cristian Kuncser ◽  
...  
Keyword(s):  
Specific Surface ◽  
Surface Area ◽  
Zno Nanoparticles ◽  
In Vitro Toxicity ◽  
Fibroblast Cells ◽  
Zno Nps ◽  
Mn Doping ◽  
Doped Zno ◽  
Mn Doped

Abstract The present study concerns the in vitro oxidative stress responses of non-malignant murine cells exposed to surfactant-tailored ZnO nanoparticles (NPs) with distinct morphologies and different levels of manganese doping. Two series of Mn-doped ZnO NPs were obtained by coprecipitation synthesis method, in the presence of either polyvinylpyrrolidone (PVP) or sodium hexametaphosphate (SHMTP). The samples were investigated by powder X-ray Diffraction, Transmission Electron Microscopy, Fourier-Transform Infrared and Electron Paramagnetic Resonance spectroscopic methods, and N2 adsorption–desorption analysis. The observed surfactant-dependent effects concerned: i) particle size and morphology; ii) Mn-doping level; iii) specific surface area and porosity. The relationship between the surfactant dependent characteristics of the Mn-doped ZnO NPs and their in vitro toxicity was assessed by studying the cell viability, intracellular reactive oxygen species (ROS) generation, and DNA fragmentation in NIH3T3 fibroblast cells. The results indicated a positive correlation between the specific surface area and the magnitude of the induced toxicological effects and suggested that Mn-doping exerted a protective effect on cells by diminishing the pro-oxidative action associated with the increase in the specific BET area. The obtained results support the possibility to modulate the in vitro toxicity of ZnO nanomaterials by surfactant-controlled Mn-doping.

scholarly journals Effect of Mn Doping on The Structural, Optical, Magnetic Properties and Antibacterial Activity of ZnO Nanospheres

2021 ◽  
Author(s):  
EBENEZAR JEYASINGH ◽  
Kelvin Adaikalam Charles ◽  
Pandiyarajan Thangaraj ◽  
Karthikeyan Chandrasekaran ◽  
Mangalaraja Ramalinga Viswanathan
Keyword(s):  
Zinc Oxide ◽  
Oxygen Vacancies ◽  
Average Particle Size ◽  
Antibacterial Properties ◽  
Ferromagnetic Phase ◽  
Average Particle ◽  
Zno Nps ◽  
Mn Doping ◽  
Doped Zno ◽  
Mn Doped

Abstract In this work, a systematic study of structural, optical, magnetic and antibacterial properties of Mn doped ZnO has been investigated. Zinc oxide (ZnO) and Mn2+ doped zinc oxide (ZnMnO) nanoparticles (NPs) were prepared through co-precipitation method. The X-ray diffraction studies confirmed that the synthesize nanoparticles did not modify the crystal structure upon Mn doping, but the microstructural parameters were changed considerably while increasing the concentration of Mn dopant. The HRTEM images showed that the ZnO NPs were exhibited nanospheres like morphology and a reduction in the average particle size from 41 nm to 33 nm were observed upon Mn2+ doping. The elemental composition of Zn, Mn and O atoms were identified by EDAX spectra. The Zn-O stretching bands were observed at 539 and 525cm-1 in the FTIR spectra and, the zinc and oxygen vacancies defects were confirmed by PL spectra. From the UV-Vis spectra, the band gap was estimated as 2.7 eV for pure and 2.9 eV for Mn doped ZnO NPs. The Mn doped ZnO NPs showed greater antibacterial effect than the pure ZnO NPs. The magnetization measurements for Mn doped ZnO samples under room temperature ferromagnetism (RTFM) showed the ferromagnetic phase that could originated from the interactions between Mn2+ ions and oxygen vacancies and the defects incorporated in the ZnO matrix.

scholarly journals Mn-Doped ZnO Nanoparticles Prepared by Solution Combustion Method

2014 ◽  
Vol 12 (0) ◽  
pp. 283-288 ◽  
Author(s):  
Murugesan Silambarasan ◽  
Shanmugam Saravanan ◽  
Tetsuo Soga
Keyword(s):  
Zno Nanoparticles ◽  
Combustion Method ◽  
Solution Combustion ◽  
Solution Combustion Method ◽  
Doped Zno ◽  
Mn Doped

Role of ZnO Nanoparticles for improvement of Antibacterial Activity in Food Packaging

2021 ◽  
pp. 128-131
Author(s):  
Saira Sehar ◽  
Amiza Amiza ◽  
I. H Khan
Keyword(s):  
Antimicrobial Activity ◽  
Particle Size ◽  
Surface Area ◽  
Zno Nanoparticles ◽  
Food Packaging ◽  
Antimicrobial Agents ◽  
Uv Light ◽  
Zno Nps ◽  
Long Time

Nanotechnology advancement leads to development of antimicrobial agents like ZnO nanoparticles. These nanoparticle have their main applications in food packaging. when these nanoparticles incorporate into the food surface, it will kill all bacterias residing on the surface and food become free of bacteria. In this way, food can be stored for a long time because its shelf life is improved. Antimicrobial activity of ZnO nanoparticles can be improved by increasing surface area, reducing particle size and large concentration of ZnO –NPS. Antimicrobial activity increases by increasing intensity of UV light. As UV light fall on ZnO nanoparticles, it increases ZnO surface area and hence anrtimicrobial activity will be increased. Exact mechanism of Antimicrobial activity is still unknown but some processes have been presented.

Magnetism in Mn-doped ZnO nanoparticles prepared by a co-precipitation method

2006 ◽  
Vol 17 (5) ◽  
pp. 1278-1285 ◽  
Author(s):  
O D Jayakumar ◽  
H G Salunke ◽  
R M Kadam ◽  
Manoj Mohapatra ◽  
G Yaswant ◽  
...  
Keyword(s):  
Zno Nanoparticles ◽  
Precipitation Method ◽  
Doped Zno ◽  
Co Precipitation ◽  
Mn Doped

scholarly journals IN VITRO GROWTH INHIBITORY EFFECT OF ZnO NANOPARTICLES ON HUMAN LIVER CANCER CELL LINES (Huh7)

2019 ◽  
pp. 191-193
Author(s):  
ANANTHALAKSHMI R ◽  
XAVIER RAJARATHINAM SR ◽  
Mohamed Sadiq A ◽  
MOHAMED SADIQ A
Keyword(s):  
Liver Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Zno Nanoparticles ◽  
Huh7 Cell ◽  
Cancer Cell Lines ◽  
Inhibitory Effect ◽  
Liver Cancer Cell ◽  
Zno Nps

Objective: The objective of the study was to access the anticancer activity of the biosynthesized ZnO nanoparticles against Huh7 liver cancer cell lines. Methods: The study was carried in vitro using Huh7 cell lines. The ZnO nanoparticles (ZnO NPs) were synthesized using Luffa acutangula peel extract and subjected to characterization by X-ray powder diffraction and transmission electron microscopy. The Huh7 cell lines were treated with ZnO NPs and done 3-(4, 5-dimethylthiazol- 2-yl)-2, 5-diphenyltetrazolium bromide assay. For live and dead assay, the cell lines treated with ZnO NPs were subjected to acridine orange/ethidium (AO/ET) bromide assay. Results: The ZnO NPs synthesized show spherical structure with 10–20 nm size. The 50% of Huh7 proliferation were inhibited at the concentration (IC50) of 40 μg/ml. The AO/ET assay shows compact nucleus and fine cytoplasmic morphology in control cells and apoptotic stage in treated cells Conclusion: This study suggests that ZnO NPs can be prepared in environment-friendly method using aqueous extract of L. acutangula and can be used in cancer treatment effectively.

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