scholarly journals Elastic fibres in alcoholic liver disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tu Vinh Luong ◽  
Sameh Abou-Beih ◽  
Jennifer Watkins ◽  
Emmanuel Tsochatzis ◽  
Massimo Pinzani ◽  
...  
Keyword(s):  
Liver Disease ◽  
Potential Role ◽  
Typical Feature ◽  
Elastic Fibre ◽  
Elastic Fibres ◽  
Oxytalan Fibres ◽  
Gradual Process ◽  
Advanced Stages ◽  
Liver Biopsies ◽  
Related Liver Disease

AbstractThe literature on the contribution of elastic fibre deposition to alcohol-related liver disease (ARLD) is limited. We studied: (1) 180 liver biopsies from ARLD patients; (2) 20 ARLD explant livers; (3) 213 liver biopsies with non-ARLD injury. Elastic fibres were assessed in terms of their distribution around hepatocytes [pericellular elastosis (PCE)] and within bridging fibrous septa (septal elastosis) and scored using a semiquantitative system. We also investigated the composition of the elastic fibres (oxytalan, elaunin and mature elastic fibres) in 20 cases. PCE was associated with steatohepatitis in ARLD patients and with ARLD when compared to non-ARLD cases (p < 0.001). Oxytalan fibres were identified in PCE in ARLD biopsies and broken dense perisinusoidal mature elastic fibres in explanted livers. Septal elastosis increased from intermediate to advanced fibrosis stage. Early septal elastosis contained oxytalan fibres, whereas septal elastosis at more advanced stages contained mainly mature elastic fibres. PCE is a typical feature of steatohepatitis in ARLD and includes oxytalan fibres. Septal elastosis is a gradual process with a transition from oxytalan to mature elastic fibres usually present in explanted livers. There may be different dynamics in the assembly and reabsorption of pericellular and septal elastic fibres, and a potential role for stratification of patients with advanced stage ARLD.

Nonalcoholic Fatty Liver Disease versus Alcohol-related Liver Disease: Is it Really so Different?

2020 ◽  
Vol 26 (10) ◽  
pp. 1093-1109 ◽  
Author(s):  
Ana Craciun ◽  
Caroline Lackner ◽  
Helena Cortez-Pinto
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Genetic Factors ◽  
Nonalcoholic Fatty Liver ◽  
Advanced Stages ◽  
The Difference ◽  
Related Liver Disease

: Nonalcoholic fatty liver disease and alcohol-related liver disease together, compose the majority of cases of liver disease and cirrhosis worldwide. Although in the last years, there has been much interest in the differentiation between the two entities, it is increasingly recognized that a large overlap exists between them. The main pathophysiological aspects are very similar, with the exceptions of mechanisms directly related to alcohol, acting as an added factor in the presence of metabolic risk factors. Genetic factors so far identified are also very similar. In both cases, the disease is more prevalent in males, the difference being more significant in the ALD group, having to do with harmful alcohol consumption, which is more frequent in males. NAFLD advanced stages usually present in older age than ALD. : Regarding laboratory features, the ratio AST/ALT < 1 is more frequent in NAFLD than ALD, in the absence of cirrhosis. Histological aspects of both situations are very similar, but some are specific for ALD, such as alcoholic foamy degeneration or cholestasis, or fibroobliterative venous lesions. Regarding treatment, several drugs now included in clinical trials in NAFLD, could also be assayed in ALD, since similar mechanisms of action, are potentially acting in ALD. In summary, similarities seem to outnumber differences, and since so large overlap between risk factors exist, the use of a common designation such as Fatty Liver Disease (FLD) or Metabolic Fatty Liver disease (MEFLD), could better serve the field.

The potential role of fucosylated cationic liposome/NFκB decoy complexes in the treatment of cytokine-related liver disease

Biomaterials ◽  
2007 ◽  
Vol 28 (3) ◽  
pp. 532-539 ◽  
Author(s):  
Yuriko Higuchi ◽  
Shigeru Kawakami ◽  
Fumiyoshi Yamashita ◽  
Mitsuru Hashida
Keyword(s):  
Liver Disease ◽  
Potential Role ◽  
Cationic Liposome ◽  
Related Liver Disease

scholarly journals Impact of Sarcopenia and Myosteatosis in Non-Cirrhotic Stages of Liver Diseases: Similarities and Differences across Aetiologies and Possible Therapeutic Strategies

Biomedicines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 182
Author(s):  
Annalisa Cespiati ◽  
Marica Meroni ◽  
Rosa Lombardi ◽  
Giovanna Oberti ◽  
Paola Dongiovanni ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Diseases ◽  
Early Stage ◽  
Alcoholic Fatty Liver ◽  
Early Stages ◽  
Advanced Stages ◽  
Related Liver Disease ◽  
And Function ◽  
The Relationship

Sarcopenia is defined as a loss of muscle strength, mass and function and it is a predictor of mortality. Sarcopenia is not only a geriatric disease, but it is related to several chronic conditions, including liver diseases in both its early and advanced stages. Despite the increasing number of studies exploring the role of sarcopenia in the early stages of chronic liver disease (CLD), its prevalence and the relationship between these two clinical entities are still controversial. Myosteatosis is characterized by fat accumulation in the muscles and it is related to advanced liver disease, although its role in the early stages is still under researched. Therefore, in this narrative review, we firstly aimed to evaluate the prevalence and the pathogenetic mechanisms underlying sarcopenia and myosteatosis in the early stage of CLD across different aetiologies (mainly non-alcoholic fatty liver disease, alcohol-related liver disease and viral hepatitis). Secondly, due to the increasing prevalence of sarcopenia worldwide, we aimed to revise the current and the future therapeutic approaches for the management of sarcopenia in CLD.

scholarly journals The natural history of histologically proved drug induced liver disease

Gut ◽  
1999 ◽  
Vol 44 (5) ◽  
pp. 731-735 ◽  
Author(s):  
P G Aithal ◽  
C P Day
Keyword(s):  
Liver Disease ◽  
Natural History ◽  
Drug Induced ◽  
Term Outcome ◽  
Long Term Outcome ◽  
History Of ◽  
Liver Biopsies ◽  
Related Liver Disease ◽  
Liver Tests

BACKGROUNDThe long term outcome of drug related liver disease is unknown.AIMSTo study the natural history of histologically proved drug induced hepatotoxicity.METHODS110 patients with liver biopsies coded either as drug induced liver disease or hepatitis/cholestasis of unknown aetiology were identified from hospital records 1978–1996. Review of case notes and histology identified 44 patients with definite drug induced hepatotoxicity. Forty surviving patients were invited to attend a follow up clinic. History, examination, full liver screen, and isotope and ultrasound liver scans were repeated in all patients. Repeat liver biopsies were offered to patients with abnormal liver tests.RESULTSPresentation at index biopsy was jaundice in 24 patients, abnormal liver tests in 17, and hepatic failure in three. Antibiotics (n=13) and non-steroidal anti-inflammatory drugs (n=11) were the most common drugs implicated. Initial histology showed acute hepatitis in six, chronic hepatitis in 20, and cholestasis in 18. At 1–19 years (median 5 years) follow up, 13/33 (39%) patients had persistent significant abnormalities in their liver blood tests and/or scans. Three of the five repeat liver biopsies performed showed significant abnormalities. Factors predicting persistence or development of chronic liver disease were fibrosis and continued exposure to the drug.CONCLUSIONSDrugs should be considered in the differential diagnosis of abnormal liver function and/or histology, as failure to withdraw the offending drug is associated with a high risk of persistent liver damage.

Detection of human cytomegalovirus DNA in liver biopsies from patients with cytomegalovirus-related liver disease

1989 ◽  
Vol 140 ◽  
pp. 361-372 ◽  
Author(s):  
P. Dény ◽  
A. Debure ◽  
H. Agut ◽  
P. Berche ◽  
F. Degos ◽  
...  
Keyword(s):  
Liver Disease ◽  
Human Cytomegalovirus ◽  
Liver Biopsies ◽  
Related Liver Disease

Crystalloid Inclusions in Hepatocyte Mitochondria and Their Similarity to Cytoplasmic Crystalloids

1974 ◽  
Vol 32 ◽  
pp. 198-199
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Special Interest ◽  
Structural Variations ◽  
Mitochondrial Alterations ◽  
The Matrix ◽  
Crystalloid Inclusions ◽  
Liver Biopsies

Mitochondrial alterations were studied in 25 liver biopsies from patients with alcoholic liver disease. Of special interest were the morphologic resemblance of certain fine structural variations in mitochondria and crystalloid inclusions. Four types of alterations within mitochondria were found that seemed to relate to cytoplasmic crystalloids.Type 1 alteration consisted of localized groups of cristae, usually oriented in the long direction of the organelle (Fig. 1A). In this plane they appeared serrated at the periphery with blind endings in the matrix. Other sections revealed a system of equally-spaced diagonal lines lengthwise in the mitochondrion with cristae protruding from both ends (Fig. 1B). Profiles of this inclusion were not unlike tangential cuts of a crystalloid structure frequently seen in enlarged mitochondria described below.

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