scholarly journals Functional impact of allelic variations/haplotypes of TNF-α on reproductive tract infections in Indian women

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vineeta Sharma ◽  
Subash Chandra Sonkar ◽  
Pallavi Singhal ◽  
Anoop Kumar ◽  
Rakesh Kumar Singh ◽  
...  
Keyword(s):  
Functional Role ◽  
Reproductive Tract ◽  
Nucleotide Polymorphisms ◽  
Reproductive Tract Infections ◽  
Confounding Bias ◽  
Tnf Α ◽  
Major Player ◽  
Tract Infections ◽  
Allelic Variations

AbstractThe aim of the present study is to investigate the functional role of TNF-α single-nucleotide polymorphisms/haplotypes in an association with reproductive tract infections (RTIs) in symptomatic and asymptomatic women. A total of 850 consecutive subjects consisting of 400 cases and 450 healthy controls, were screened for RTIs, along with their risk factors and associated symptoms. The propensity score matching was performed to reduce the confounding bias arise owing to covariates and to balance the data between two groups. A total of 211 pairs (1:1) have been created. Genotyping of rs1800629 (-308) and rs361525 (-238) SNPs of TNF-α was done by PCR–RFLP followed by sequencing. The functional implication of TNF-α SNPs in an association with RTIs was also checked by using ELISA. The frequency of -238A allele and -308A allele was found to be twofold (P < 0.0001) and threefold (P < 0.0001) higher in the presence of RTIs. AA haplotype emerged as a major player in an association with RTIs and elevated TNF-α expression. The present study revealed the functional role of rs1800629 (-308) and rs361525 (-238) of TNF-α in an association with RTIs. This information may be used to establish biomarkers for an inflammatory response during the persistence of RTIs.

scholarly journals Etiopathogenesis of reproductive tract infections and the emerging role of bitter taste receptors: A scoping review

2021 ◽  
Vol 10 (4) ◽  
pp. 145
Author(s):  
MenizibeyaO Welcome ◽  
Abraham Jeremiah ◽  
DennisO Allagoa ◽  
Senol Dane ◽  
VladimirA Pereverzev
Keyword(s):  
Scoping Review ◽  
Reproductive Tract ◽  
Bitter Taste ◽  
Taste Receptors ◽  
Reproductive Tract Infections ◽  
Bitter Taste Receptors ◽  
Tract Infections

scholarly journals Association of TNF-α rs-281865419 polymorphism with reproductive tract infections in Indian population

2016 ◽  
Author(s):  
Vineeta Sharma ◽  
Pallavi Singhal ◽  
Anoop Kumar ◽  
V. G. Ramachandran ◽  
Shukla Das ◽  
...  
Keyword(s):  
Indian Population ◽  
Reproductive Tract ◽  
North India ◽  
Reproductive Tract Infections ◽  
Homozygous Genotype ◽  
Tnf Α ◽  
Pcr Rflp ◽  
Polymorphic Genotype ◽  
Tract Infections ◽  
Asymptomatic Women

Aim: To investigate the presence of reproductive tract infections (RTIs) in symptomatic and asymptomatic women in North India and association of SNPs in TNFα gene (rs-281865419 C/T) with susceptibility to these RTIs. Methods: We collected 100 symptomatic (cases) and 100 asymptomatic women (controls) samples and screened them for RTIs. Then genotyping of TNF-α gene was performed by PCR-RFLP. Results: Among cases the frequencies of RTIs infection is higher than control. The prevalence of HPV, C. trachomatis, T. vaginalis, Bacterial vaginosis and N. gonorrhoeae are 28% & 6%; 11%, 32% respectively while in controls it was 5%, 2%, 1% and 8% & 1%. In the present study we found that the frequency of wild homozygous genotype (TT) was lower in cases 30% (6/20) as compared to controls 60% (12/20). The frequency of the heterozygous polymorphic genotype (CT) was higher in cases 65% (65/100) as compared to controls 32% (32/100). It was interesting to note that the frequency of the polymorphic homozygous genotype (CC) was higher in cases 15% (15/100) than controls 2% (2/100). While the frequency of the carrier genotype (CT + TT) was found to be more in cases 70% (70/100) than in controls 40/100 (40%). This study shows that T allele may be risk factor for Reproductive tract infections as its percentage is higher in cases as compare to normal controls. Conclusion: TNF-? rs-281865419 locus may serve as an important biomarker for RTIs predisposition in Indian population though larger sample size is needed to validate the findings.

scholarly journals Reproductive Tract Infections in Dairy Cows: Can Probiotics Curb Down the Incidence Rate?

Dairy ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 40-64
Author(s):  
Eduardo Barahona Rosales ◽  
Burim N. Ametaj
Keyword(s):  
Dairy Cows ◽  
Reproductive Tract ◽  
Negative Impact ◽  
Systemic Circulation ◽  
Contributing Factors ◽  
Reproductive Tract Infections ◽  
Uterine Health ◽  
Lower Fertility ◽  
Tract Infections ◽  
Uterine Diseases

Postpartum uterine diseases are common in dairy cows and are a great concern for the dairy industry as they are associated with various consequences, including lower fertility, lower milk yield, and an overall negative impact on the host health. An infected uterus is a source of bacterial compounds and cytokines that spill into the systemic circulation, spreading inflammation to other organs. In this review article, we discuss a short overview of the anatomy of the reproductive tract of dairy cows and several infectious diseases of the uterus including metritis, endometritis, and pyometra. Additionally, we discuss the microbiome of the reproductive tract in health and during uterine diseases. As well, diagnostic criteria for metritis and endometritis and contributing factors for increased susceptibility to metritis infection are important topics of this review. To better understand how the uterus and reproductive tract respond to bacterial pathogens, a section of this review is dedicated to immunity of the reproductive tract. Both the innate and adaptive immunity systems are also discussed. We conclude the review with a factual discussion about the current treatments of uterine diseases and the new developments in the area of application of probiotics for uterine health. Mechanisms of actions of probiotics are discussed in detail and also some applications to prevent uterine infections in dairy cows are discussed.

scholarly journals Identifying Risk Factors for Lower Reproductive Tract Infections among Women Using Reusable Absorbents in Odisha, India

2021 ◽  
Vol 18 (9) ◽  
pp. 4778
Author(s):  
Padmalaya Das ◽  
Danielle Lisnek ◽  
Krushna Chandra Sahoo ◽  
Shalini Sinha ◽  
JyotiRanjan Mohanty ◽  
...  
Keyword(s):  
Risk Factors ◽  
Reproductive Tract ◽  
Laboratory Diagnosis ◽  
Poverty Line ◽  
Reproductive Age ◽  
Reproductive Tract Infections ◽  
Menstrual Hygiene ◽  
Socio Demographic Factors ◽  
Tract Infections ◽  
Study Laboratory

A large proportion of women in Odisha, India, use reusable absorbents to manage their menstruation. Yet, the risk factors for lower reproductive tract infections (RTIs) related to menstrual hygiene management (MHM) have not been studied among reusable absorbent users. Women of reproductive age attending one of two hospitals from two different cities in Odisha during two separate study intervals were recruited for the study. Laboratory diagnosis of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) were conducted. A questionnaire was used to collect information on MHM practices, water, sanitation, and socio-demographic factors. Among the 509 women who used reusable absorbents, 71.7% were diagnosed with at least one infection. After adjusting for confounders, women with BV were more likely to identify as being a housewife (aOR: 1.8 (1.1–2.9)). Frequent absorbent changing was protective against BV (aOR: 0.5 (0.3–0.8)), whereas frequent body washing increased the odds of BV (aOR: 1.5 (1.0–2.2)). Women with VVC were more likely to be older (aOR: 1.6 (1.0–2.5)), live below the poverty line (aOR: 1.5 (1.1–2.2)), have a non-private household latrine (aOR: 2.2 (1.3–4.0)), dry their absorbents inside the house (aOR: 3.7 (2.5–4.5)), and store absorbents in the latrine area (aOR: 2.0 (1.3–2.9)). Washing absorbents outside the house was protective against VVC (aOR: 0.7 (0.4–1.0)). This study highlights the importance of improving MHM practices among reusable absorbent users to prevent lower RTIs among women reusing menstrual materials in Odisha.

scholarly journals Reproductive tract infections in women seeking abortion in Vietnam

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Nguyn M Hng ◽  
Jørgen Kurtzhals ◽  
Th Thu Thy ◽  
Vibeke Rasch
Keyword(s):  
Reproductive Tract ◽  
Reproductive Tract Infections ◽  
Tract Infections
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