scholarly journals Additive and interaction effects of working memory and motor sequence training on brain functional connectivity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Priska Zuber ◽  
Laura Gaetano ◽  
Alessandra Griffa ◽  
Manuel Huerbin ◽  
Ludovico Pedullà ◽  
...  
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Processing Speed ◽  
Resting State ◽  
Resting State Fmri ◽  
Interactive Effects ◽  
Angular Gyrus ◽  
Precentral Gyrus ◽  
Motor Sequence ◽  
Brain Functional Connectivity

AbstractAlthough shared behavioral and neural mechanisms between working memory (WM) and motor sequence learning (MSL) have been suggested, the additive and interactive effects of training have not been studied. This study aimed at investigating changes in brain functional connectivity (FC) induced by sequential (WM + MSL and MSL + WM) and combined (WM × MSL) training programs. 54 healthy subjects (27 women; mean age: 30.2 ± 8.6 years) allocated to three training groups underwent twenty-four 40-min training sessions over 6 weeks and four cognitive assessments including functional MRI. A double-baseline approach was applied to account for practice effects. Test performances were compared using linear mixed-effects models and t-tests. Resting state fMRI data were analysed using FSL. Processing speed, verbal WM and manual dexterity increased following training in all groups. MSL + WM training led to additive effects in processing speed and verbal WM. Increased FC was found after training in a network including the right angular gyrus, left superior temporal sulcus, right superior parietal gyrus, bilateral middle temporal gyri and left precentral gyrus. No difference in FC was found between double baselines. Results indicate distinct patterns of resting state FC modulation related to sequential and combined WM and MSL training suggesting a relevance of the order of training performance. These observations could provide new insight for the planning of effective training/rehabilitation.

scholarly journals Aberrant Brain Functional Connectivity Related to Insulin Resistance in Type 2 Diabetes: A Resting-State fMRI Study

Diabetes Care ◽  
2014 ◽  
Vol 37 (6) ◽  
pp. 1689-1696 ◽  
Author(s):  
Yu-Chen Chen ◽  
Yun Jiao ◽  
Ying Cui ◽  
Song-An Shang ◽  
Jie Ding ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Fmri ◽  
Fmri Study ◽  
Brain Functional Connectivity

scholarly journals ALTERED BRAIN FUNCTIONAL CONNECTIVITY FOLLOWING A SEASON OF COMPETITIVE FEMALE HIGH SCHOOL SOCCER AND THE EFFECT OF A JUGULAR VEIN COMPRESSION COLLAR: A NETWORK-BASED STATISTICS ANALYSIS

2020 ◽  
Vol 8 (4_suppl3) ◽  
pp. 2325967120S0026
Author(s):  
Jonathan A. Dudley ◽  
Jed A. Diekfuss ◽  
Weihong Yuan ◽  
Kim D. Barber Foss ◽  
Christopher A. DiCesare ◽  
...  
Keyword(s):  
High School ◽  
Functional Connectivity ◽  
Resting State ◽  
Female Athletes ◽  
Jugular Vein ◽  
Resting State Fmri ◽  
Head Impacts ◽  
Brain Functional Network ◽  
Female High School ◽  
Brain Functional Connectivity

Background: Cumulative exposure to repetitive sub-concussive head impacts in contact sports may have deleterious effects on brain function, even in the absence of acute symptoms. Moreover, anatomical and biomechanical factors may predispose female athletes to higher risk compared to males. At present, there is no effective injury prevention strategy to protect female athletes from sports-related head impact. Hypothesis/Purpose: (1). We aimed to use resting-state fMRI to investigate the effect of a full season of competitive soccer on brain functional network integrity in female high school athletes. (2). We also aimed to evaluate the efficacy of a jugular vein compression neck collar device, designed to mitigate potential injury by reducing the brain slosh effect. Methods: A total of 125 high school female soccer athletes were included in this study. These athletes were assigned randomly to a non-collar (n=55, age=16.06±1.06 yrs) or collar group (n=70, 15.81±0.95 yrs) before the season started. High resolution 3D T1-weighted images and resting-state fMRI data were collected prospectively at pre-season and again at post-season. Data processing and analysis were conducted in the MATLAB-based programs Statistical Parametric Mapping (SPM12) and Connectivity Toolbox (Conn). Functional connectivity was computed between each pair of 105 anatomically delineated regions of interest (ROI). Network Based Statistics were applied to detect coherent patterns of altered connectivity from pre- to post-season. Results: The non-collar group showed a significant pattern of altered connectivity (p-FWE = 0.047) spanning 60% of ROIs (63/105) and 1.7% of ROI-ROI connections (94/5,460). 65 of the 94 altered connections were weakened from pre-to-post season and tended to occur in the right hemisphere. 29 of the 94 altered connections were strengthened from pre-to-post season and tended to involve regions in the occipital lobe. The collar group did not show any statistically significant change (p-FWE = 0.223). Conclusion: The results of this study indicate that exposure to repetitive sub-concussive head impacts during a single season of competitive female soccer induces changes in brain functional connectivity. The observed increases and decreases of functional connectivity strength comprising the pattern of altered connectivity are congruent with a heterogeneous response to insult wherein some connections are reduced in strength due to neuronal damage and other “detour” connections are strengthened to preserve network function. Comparatively, the absence of alterations in the collar group suggest that the jugular vein compression collar may have generated a potentially protective effect to preserve brain functional network integrity during exposure to head impacts. [Figure: see text]

Changes in brain functional connectivity patterns are driven by an individual lesion in MS: a resting-state fMRI study

2015 ◽  
Vol 10 (4) ◽  
pp. 1117-1126 ◽  
Author(s):  
Amgad Droby ◽  
Kenneth S. L. Yuen ◽  
Muthuraman Muthuraman ◽  
Sarah-Christina Reitz ◽  
Vinzenz Fleischer ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Resting State Fmri ◽  
Fmri Study ◽  
Connectivity Patterns ◽  
Brain Functional Connectivity

scholarly journals Visual processing speed is linked to functional connectivity between right frontoparietal and visual networks

2020 ◽  
Author(s):  
Svenja Küchenhoff ◽  
Christian Sorg ◽  
Sebastian Schneider ◽  
Oliver Kohl ◽  
Hermann J. Müller ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Visual Attention ◽  
Processing Speed ◽  
Resting State ◽  
Visual Processing ◽  
Visual Information ◽  
Resting State Fmri ◽  
Healthy Human ◽  
Speed Parameter ◽  
Visual Processing Speed

AbstractVisual information processing requires an efficient visual attention system. The neural theory of visual attention (TVA) proposes that visual processing speed depends on the coordinated activity between frontoparietal and occipital brain areas. Previous research has shown that the coordinated activity between (i.e., functional connectivity, ‘inter-FC’) cingulo-opercular (COn) and right-frontoparietal (RFPn) networks is linked to visual processing speed. However, evidence for how inter-FC of COn and RFPn with visual networks links to visual processing speed is still missing. Forty-eight healthy human adult participants (27 females) underwent resting-state (rs-)fMRI and performed a whole-report psychophysical task. To obtain inter-FC, we analyzed the entire frequency range available in our rs-fMRI data (i.e., 0.01-0.4 Hz) to avoid discarding neural information. Following previous approaches, we analyzed the data across frequency bins (Hz): Slow-5 (0.01-0.027), Slow-4 (0.027-0.073), Slow-3 (0.073-0.198), and Slow-2 (0.198-0.4). We used the mathematical TVA framework to estimate an individual, latent-level visual processing speed parameter. We found that visual processing speed was negatively associated with inter-FC between RFPn and visual networks in Slow-5 and Slow-2, with no corresponding significant association for inter-FC between COn and visual networks. These results provide first empirical evidence that links inter-FC between RFPn and visual networks with the visual processing speed parameter. These findings suggest a direct connectivity between occipital and right frontoparietal, but not frontoinsular, regions, to support visual processing speed.Significance statementAn efficient visual processing is at the core of visual cognition. Here, we provide evidence for a brain correlate of how fast individuals process visual stimuli. We used mathematical modeling of performance in a visual report task to estimate visual processing speed. A frequency-based analysis of resting-state fMRI signals revealed that functional connectivity between the right frontoparietal network and primary and dorsal occipital networks is linked to visual processing speed. This link was present in the slowest, typical frequency of the fMRI signal but also in the higher frequencies that are routinely discarded. These findings imply that the coordinated spontaneous activity between right frontoparietal and occipital regions supports the individual potential of the visual system for efficient processing.

scholarly journals Wearing a KN95/FFP2 Facemask Has Subtle Effects on Functional Salience Network Interaction

2022 ◽  
Author(s):  
Sven HALLER ◽  
Marie-Louise MONTANDON ◽  
Cristelle RODRIGUEZ ◽  
Panteleimon GIANNAKOPOULOS
Keyword(s):  
Heart Rate ◽  
Functional Connectivity ◽  
Resting State Fmri ◽  
Seed Region ◽  
Self Awareness ◽  
Precentral Gyrus ◽  
Fmri Study ◽  
The Many ◽  
High Level ◽  
Brain Functional Connectivity

Abstract BackgroundWide use of wearing a facemask is one of the many consequences of the COVID-19 pandemic. We used resting-state fMRI to search for subtle changes in brain functional connectivity, expected notably related to the high-level salience (SN) and default mode networks (DMN).Materials and MethodsProspective crossover design resting fMRI study with/without wearing a tight FFP2/KN95 facemask, including 24 consecutive male participants (mean age ± SD = 29.9 ± 6.9 years) at 3T. As physiological parameters, respiration frequency and heart rate were monitored. Data analysis was performed using the CONN toolbox.ResultsWearing an FFP2/KN95 facemask did not impact respiration or heart rate but resulted in a significant reduction in functional connectivity between the SN as the seed region and the left middle frontal and precentral gyrus. No difference was found when the DMN, sensorimotor, visual, dorsal attention or language networks were used as seed regions.ConclusionsThe wearing of tight FFP2/KN95 facemasks in men decreases the functional connectivity of the SN, which is known to be involved in communication, social behavior and self-awareness. This phenomenon was confined to the left frontal and precentral gyrus. Our results imply that the wearing of a facemask could impact our ability to detect and react appropriately to salient stimuli by altering the functional connectivity of the SN.

Fine-grained mapping of mouse brain functional connectivity with resting-state fMRI

NeuroImage ◽  
2014 ◽  
Vol 96 ◽  
pp. 203-215 ◽  
Author(s):  
Anna E. Mechling ◽  
Neele S. Hübner ◽  
Hsu-Lei Lee ◽  
Jürgen Hennig ◽  
Dominik von Elverfeldt ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Mouse Brain ◽  
Resting State ◽  
Resting State Fmri ◽  
Fine Grained ◽  
Brain Functional Connectivity

Brain Functional Connectivity in OCD

2017 ◽  
Author(s):  
Carles Soriano-Mas ◽  
Ben J. Harrison
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Large Scale ◽  
Resting State Fmri ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Regulatory Systems ◽  
Variable Nature ◽  
Brain Functional Connectivity ◽  
Or Task

This chapter provides an overview of studies assessing alterations in brain functional connectivity in obsessive-compulsive disorder (OCD) as assessed by functional magnetic resonance imaging (fMRI). Although most of the reviewed studies relate to the analysis of resting-state fMRI data, the chapter also reviews studies that have combined resting-state with structural or task-based approaches, as well as task-based studies in which the analysis of functional connectivity was reported. The main conclusions to be drawn from this review are that patients with OCD consistently demonstrate altered patterns of brain functional connectivity in large-scale “frontostriatal” and “default mode” networks, and that the heterogeneity of OCD symptoms is likely to partly arise via distinct modulatory influences on these networks by broader disturbances of affective, motivational, and regulatory systems. The variable nature of some findings across studies as well as the influence of medications on functional connectivity measures is also discussed.

Sign in / Sign up

Export Citation Format

Share Document