scholarly journals Circulating neurotrophins and hemostatic risk factors of atherothrombotic cardiovascular disease at baseline and during sympathetic challenge: the SABPA study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Roland von Känel ◽  
Mark Hamer ◽  
Annemarie Wentzel ◽  
Leoné Malan
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Neurotrophic Factor ◽  
Calcium Binding ◽  
Black And White ◽  
Lower Baseline ◽  
Coronary Syndromes ◽  
Von Willebrand ◽  
Protein S100b ◽  
D Dimer

AbstractSympathetic activation may trigger acute coronary syndromes. We examined the relation between circulating neurotrophic factors and hemostatic risk factors of atherothrombotic cardiovascular disease at baseline and in response to acute mental stress to establish a brain–heart link. In 409 black and white South Africans, brain-derived neurotrophic factor (BDNF) and fibrinolytic measures were assessed at baseline. Glial cell-derived neurotrophic factor (GDNF), S100 calcium-binding protein (S100B), von Willebrand factor (VWF), fibrinogen and D-dimer were assessed at baseline and 10 min after the Stroop test. Neurotrophins were regressed on hemostatic measures adjusting for demographics, comorbidities, cardiometabolic factors and health behaviors. Higher baseline BDNF was associated with greater stress-induced increase in fibrinogen (p = 0.003) and lower D-dimer increase (p = 0.016). Higher baseline S100B was significantly associated with higher baseline VWF (p = 0.031) and lower fibrinogen increase (p = 0.048). Lower baseline GDNF was associated with higher baseline VWF (p = 0.035) but lower VWF increase (p = 0.001). Greater GDNF (p = 0.006) and S100B (p = 0.042) increases were associated with lower VWF increase. All associations showed small-to-moderate effect sizes. Neurotrophins and fibrinolytic factors showed no significant associations. The findings support the existence of a peripheral neurothrophin-hemostasis interaction of small-to-moderate clinical relevance. The implications for atherothrombotic cardiovascular disease need further exploration.

Overweight, fat patterning, and cardiovascular disease risk factors in black and white boys

1999 ◽  
Vol 135 (4) ◽  
pp. 451-457 ◽  
Author(s):  
John A. Morrison ◽  
Bruce A. Barton ◽  
Frank M. Biro ◽  
Stephen R. Daniels ◽  
Dennis L. Sprecher
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors ◽  
Black And White

The predictive value of markers of fibrinolysis and endothelial dysfunction in the post thrombotic syndrome

2014 ◽  
Vol 111 (06) ◽  
pp. 1031-1040 ◽  
Author(s):  
Anat Rabinovich ◽  
Jacqueline M. Cohen ◽  
Susan R. Kahn
Keyword(s):  
Risk Factors ◽  
Endothelial Dysfunction ◽  
Factor Xiii ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Post Thrombotic Syndrome ◽  
Definition Of ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
D Dimer

SummaryThe post thrombotic syndrome (PTS) develops in 20–40% of deep venous thrombosis (DVT) patients. Risk factors for PTS have not been well elucidated. Identification of risk factors would facilitate individualised risk assessment for PTS. We conducted a systematic review to determine whether biomarkers of fibrinolysis or endothelial dysfunction can predict the risk for PTS among DVT patients. Studies were identified by searching the electronic databases PubMed, EMBASE, Scopus and Web of science. We included studies published between 1990 and 2013, measured biomarker levels in adult DVT patients, and reported rates of PTS development. Fourteen studies were included: 11 investigated the association between D-dimer and PTS; three examined fibrinogen; two measured von Willebrand factor; one measured plasminogen activator inhibitor-1; one assessed ADAMTS-13 (A Disintegrin and Metalloprotease with Thrombospondin type 1 repeats) and one measured factor XIII activity. Studies varied with regards to inclusion criteria, definition of PTS, time point and method of biomarker measurement. We were unable to meta-analyse results due to marked clinical heterogeneity. Descriptively, a significant association with PTS was found for D-dimer in four studies and factor XIII in one study. Further prospective research is needed to elucidate whether these markers might be useful to predict PTS development.

scholarly journals Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection

AIDS ◽  
2010 ◽  
Vol 24 (10) ◽  
pp. 1509-1517 ◽  
Author(s):  
Emily S Ford ◽  
Jamieson H Greenwald ◽  
Aaron G Richterman ◽  
Adam Rupert ◽  
Lauren Dutcher ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Hiv Infection ◽  
Traditional Risk Factors ◽  
Incident Cardiovascular Disease ◽  
D Dimer ◽  
Chronic Hiv Infection

Concentrations of Lp(a) in black and white young adults: Relations to risk factors for cardiovascular disease

1994 ◽  
Vol 4 (5) ◽  
pp. 341-350 ◽  
Author(s):  
Barbara V. Howard ◽  
Ngoc-Anh Le ◽  
John D. Belcher ◽  
John M. Flack ◽  
David R. Jacobs ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Young Adults ◽  
Black And White

DNA-Polymorphisms and Plasma Levels of Vascular Disease Risk Factors in Greenland Inuit

1999 ◽  
Vol 81 (04) ◽  
pp. 547-552 ◽  
Author(s):  
Moniek P. M. de Maat ◽  
Else Marie Bladbjerg ◽  
Lars G. Johansen ◽  
Peter de Knijff ◽  
Jørgen Gram ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
High Risk ◽  
Plasma Levels ◽  
Disease Risk ◽  
Allele Frequencies ◽  
Cvd Risk ◽  
Risk Alleles ◽  
Pai 1 ◽  
D Dimer

SummaryGreenland Inuit are a population with a low risk of cardiovascular disease. Recently, we stated that frequencies of potentially high risk alleles of the apolipoproteins, fibrinogen, factor V, glycoprotein IIIa and factor VII (FVII) genes have different allele frequencies in the Inuit when compared with Caucasian populations. We have extended this study and evaluated whether or not this was also true for the genetic polymorphisms of tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), angiotensin-converting enzyme (ACE) and angiotensinogen in a group of 133 Greenland Inuit, aged 30-34 y. In addition, we compared the plasma levels of these factors and those of C-reactive protein (CRP) and D-Dimer in Inuit and in Danes, comparable for age and gender. Frequencies (f) were assessed of the alleles that are known as the potential high risk alleles in Caucasians.In the Inuit, the f(insertion allele) of the t-PA intron8ins311 polymorphism was 0.37 (CI 0.32-0.43), the f(4G allele) of the PAI-1 promoter polymorphism was 0.88 (CI 0.83-0.91), the f(deletion allele) of the ACE intron16ins287 polymorphism was 0.40 (CI 0.33-0.47) and the f(M-allele) of the angiotensinogen M/T353 polymorphism was 0.30 (CI 0.25-0.38). As for fibrinogen and FVII polymorphisms, these frequencies are all significantly different from what is reported for Caucasian populations. In the Inuit, plasma levels of fibrinogen and D-Dimer were higher than in the Danes, the PAI-1 levels were lower and FVII, t-PA and CRP levels were comparable. The observed allele frequencies of the polymorphisms of t-PA, fibrinogen, FVII, ACE, angiotensinogen and the plasma levels of PAI-1 and D-Dimer were in accordance with the low CVD risk in the Inuit, considering the observed associations between these measures and CVD risk in Caucasian populations, but for other measures this was not the case (allele frequencies of the PAI-1 polymorphism, and plasma levels of fibrinogen, FVII and t-PA).In conclusion there are clear differences in genetic background and plasma levels of risk factors in Greenland Inuit compared with Caucasian populations, and these differences were sometimes, but not always, in accordance with the observed low cardiovascular disease risk of the Inuit population.

scholarly journals Relationship of Visceral Adiposity to Cardiovascular Disease Risk Factors in Black and White Teens*

Obesity ◽  
2007 ◽  
Vol 15 (4) ◽  
pp. 1029-1035 ◽  
Author(s):  
Bernard Gutin ◽  
Maribeth H. Johnson ◽  
Matthew C. Humphries ◽  
Jeannie L. Hatfield-Laube ◽  
Gaston K. Kapuku ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Visceral Adiposity ◽  
Cardiovascular Disease Risk Factors ◽  
Black And White ◽  
Relationship Of
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