scholarly journals Altered sleep behavior in a genetic mouse model of impaired fear extinction

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eva Maria Fritz ◽  
Matthias Kreuzer ◽  
Alp Altunkaya ◽  
Nicolas Singewald ◽  
Thomas Fenzl
Keyword(s):  
Sleep Disturbances ◽  
Inbred Mouse ◽  
Inbred Mouse Strain ◽  
Emotional Memory ◽  
Fear Extinction ◽  
Face Validity ◽  
Poor Sleep ◽  
Post Traumatic Stress ◽  
Secondary Symptom ◽  
Sleep Behavior

AbstractSleep disturbances are a common complaint of anxiety patients and constitute a hallmark feature of post-traumatic stress disorder (PTSD). Emerging evidence suggests that poor sleep is not only a secondary symptom of anxiety- and trauma-related disorders but represents a risk factor in their development, for example by interfering with emotional memory processing. Fear extinction is a critical mechanism for the attenuation of fearful and traumatic memories and multiple studies suggest that healthy sleep is crucial for the formation of extinction memories. However, fear extinction is often impaired in anxiety- and trauma-related disorders—an endophenotype that is perfectly modelled in the 129S1/SvImJ inbred mouse strain. To investigate whether these mice exhibit altered sleep at baseline that could predispose them towards maladaptive fear processing, we compared their circadian sleep/wake patterns to those of typically extinction-competent C57BL/6 mice. We found significant differences regarding diurnal distribution of sleep and wakefulness, but also sleep architecture, spectral features and sleep spindle events. With regard to sleep disturbances reported by anxiety- and PTSD patients, our findings strengthen the 129S1/SvImJ mouse models’ face validity and highlight it as a platform to investigate novel, sleep-focused diagnostic and therapeutic strategies. Whether the identified alterations causally contribute to its pathological anxiety/PTSD-like phenotype will, however, have to be addressed in future studies.

scholarly journals Impaired Pavlovian fear extinction is a common phenotype across genetic lineages of the 129 inbred mouse strain

2009 ◽  
Vol 8 (8) ◽  
pp. 744-752 ◽  
Author(s):  
M. Camp ◽  
M. Norcross ◽  
N. Whittle ◽  
M. Feyder ◽  
W. D’Hanis ◽  
...  
Keyword(s):  
Mouse Strain ◽  
Inbred Mouse ◽  
Inbred Mouse Strain ◽  
Fear Extinction ◽  
Genetic Lineages ◽  
Common Phenotype

Abnormal REM Sleep Atonia Control in Chronic Post-Traumatic Stress Disorder

SLEEP ◽  
2021 ◽  
Author(s):  
John C Feemster ◽  
Tyler A Steele ◽  
Kyle P Palermo ◽  
Christy L Ralston ◽  
Yumeng Tao ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Sleep Disturbances ◽  
Stress Disorder ◽  
Rem Sleep Behavior Disorder ◽  
Post Traumatic Stress ◽  
Sleep Behavior ◽  
Chronic Ptsd ◽  
Post Traumatic

Abstract Study Objectives Post-traumatic stress disorder (PTSD) and REM sleep behavior disorder (RBD) share some common features including prominent nightmares and sleep disturbances. We aimed to comparatively analyze REM sleep without atonia (RSWA) between patients with chronic PTSD with and without dream enactment behavior (DEB), isolated RBD (iRBD), and controls. Methods In this retrospective study, we comparatively analyzed 18 PTSD with DEB (PTSD+DEB), 18 PTSD without DEB, 15 iRBD, and 51 controls matched for age and sex. We reviewed medical records to determine PTSD clinical features and quantitatively analyzed RSWA. We used non-parametric analyses to compare clinical and polysomnographic features. Results PTSD patients, both with and without DEB, had significantly higher RSWA than controls (all p < 0.025, excepting submentalis phasic duration in PTSD+DEB). Most RSWA measures were also higher in PTSD+DEB than in PTSD without DEB patients (all p <0.025). Conclusions PTSD patients have higher RSWA than controls, whether DEB is present or not, indicating that REM sleep atonia control is abnormal in chronic PTSD. Further prospective studies are needed to determine whether neurodegenerative risk and disease markers similar to RBD might occur in PTSD patients.

scholarly journals Sleep and PTSD in the Military Forces: A Reciprocal Relationship and a Psychiatric Approach

2021 ◽  
Vol 11 (10) ◽  
pp. 1310
Author(s):  
Saguin Emeric ◽  
Gomez-Merino Danielle ◽  
Sauvet Fabien ◽  
Leger Damien ◽  
Chennaoui Mounir
Keyword(s):  
Rem Sleep ◽  
Sleep Disturbances ◽  
Emotional Memory ◽  
Combat Exposure ◽  
Reciprocal Relationship ◽  
Post Traumatic Stress ◽  
Research Perspectives ◽  
Military Forces ◽  
Restorative Sleep ◽  
The Military

Sleep disturbances are well-recognised symptoms of Post-Traumatic Stress Disorder (PTSD). This review updates knowledge regarding the relationship between sleep during deployment, combat-related trauma, and PTSD in military personnel, from which the importance of restorative sleep results. The description of the characteristics of sleep in military forces with the considerable roles of the operational and training contexts highlights the important consequences of degraded sleep. Indeed, a lot of data suggest a dynamic link between sleep and the onset and chronicity of PTSD. We propose a reciprocal relationship model with strategies strongly recommended or already adopted by the military to promote restorative sleep before and after combat exposure. Among the alterations in a variety of sleep architecture and sleep patterns described in PTSD, the physiological hypothesis of REM sleep fragmentation in the development of PTSD symptoms may be important because REM sleep is generally associated with emotional memory. Finally, we address clinical and research perspectives that could be used to detect or restore sleep continuity before and during military deployment to possibly alleviate nightmares and insomnia related to combat exposure and PTSD occurrence and improve our understanding of sleep in PTSD.

scholarly journals 196 Sleeping Through a Pandemic: Sleep Health in Adults Around the World During the COVID-19 Lockdown

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A79-A79
Author(s):  
Dilara Yuksel ◽  
Grace McKee ◽  
Paul Perrin ◽  
Elisabet Alzueta ◽  
Sendy Caffarra ◽  
...  
Keyword(s):  
Sleep Disturbances ◽  
Financial Strain ◽  
Mitigation Measures ◽  
Poor Sleep ◽  
Sleep Health ◽  
Related Factors ◽  
Sleep Behavior ◽  
Global Comparison ◽  
The World ◽  
Good Sleep

Abstract Introduction The novel COVID-19 disease rapidly escalated into a global pandemic affecting people around the world. While communities imposed mitigation measures to stop the spread of the disease, the mass (home) confinement in addition to the uncertainty of the pandemic led to drastic changes in all aspects of life, including sleep. Sleep health is strongly linked with mental and overall health and could play a protective role against the development of mental distress during the pandemic. Here, we investigated sleep health in a global multicultural sample of adults during the COVID-19 pandemic. Methods We surveyed 6,882 adults (18-94 years) across 59 countries about their sleep health (RU-SATED scale), sleep behaviors, demographics, pandemic-related factors, and mood between late April and early May 2020. A hierarchical stepwise multiple linear regression was performed to investigate correlates of sleep health. Results Compared with pre-pandemic times, more than one third of the sample reported an increase in sleep disturbances, and more than half of the sample shifted their sleep schedule towards later bed- and wake-up times. Better sleep health was associated with being partnered, older age and living in a higher-income country (p<.001). Poorer sleep health was associated with a stricter level of quarantine, and other pandemic-related factors including being laid off from job, financial strain, or difficulties with transitioning to working from home (R2=.116, p<.001). Domestic conflict emerged as the strongest correlate of poorer sleep health in the regression model. Greater depression and anxiety symptoms were associated with a poorer sleep health (p<.001). In a global comparison, Latin Americans reported the lowest sleep health scores. Conclusion Our findings highlight how sleep behavior has changed during the international quarantine- and isolation measurements and show the association between pandemic-related factors and poor sleep health, which, in turn, is closely linked with poorer mental health. These results emphasize the importance of maintaining good sleep health during the pandemic, since poorer sleep health may trigger or exacerbate mental disorders. Maintenance of good sleep health should be incorporated into public health messages aimed at helping people maintain optimal mental and physical health during major stressful life events like the COVID-19 pandemic. Support (if any):

scholarly journals Impaired learning, memory, and extinction in posttraumatic stress disorder: translational meta-analysis of clinical and preclinical studies

2021 ◽  
Author(s):  
Milou S. C. Sep ◽  
Elbert Geuze ◽  
Marian Joëls
Keyword(s):  
Animal Models ◽  
Animal Studies ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Emotional Memory ◽  
Fear Extinction ◽  
Current Evidence ◽  
Preclinical Studies ◽  
Post Traumatic Stress ◽  
Trauma Memory

Background. Current evidence-based treatments for post-traumatic stress disorder (PTSD) are efficacious in only part of PTSD patients. Therefore, novel neurobiologically-informed approaches are urgently needed. Clinical and translational neuroscience point to altered learning and memory processes as key in (models of) PTSD psychopathology. We extended this notion by clarifying at a meta-level i) the role of information valence, i.e. neutral versus emotional/fearful, and ii) comparability between clinical and preclinical phenotypes. We hypothesized that, cross-species, neutral versus emotional/fearful information processing is, respectively, impaired and enhanced in PTSD. Methods. This preregistered meta-analysis involved a literature search on PTSD+Learning/Memory+Behavior, performed in PubMed. First, the effect of information valence was estimated with a random-effects meta-regression. Then sources of variation were explored with a random forest-based analysis. Results. The analyses included 92 clinical (N=6732 humans) and 182 preclinical (N=6834 animals) studies. A general impairment of learning, memory and extinction processes was observed in PTSD patients, regardless of information valence. Impaired neutral learning/memory and fear extinction were also present in animal models of PTSD. Yet, PTSD enhanced fear/trauma memory in preclinical studies and impaired emotional memory in patients. Clinical data on fear/trauma memory was limited. Mnemonic phase and valence explained most variation in rodents but not humans. Conclusions. Impaired neutral learning/memory and fear extinction show very stable cross-species PTSD phenotypes. These could be targeted for novel PTSD treatments, building on neurobiological animal studies. We argue that seemingly cross-species discrepancies in emotional/fearful memory deserve further study; until then animal models targeting this phenotype should be applied with care.

THE RELATIONSHIP BETWEEN SMART PHONE USAGE AND SLEEP DISTURBANCES AND PSYCHOLOGICAL DISSTRESS AMONG STUDENTS

2017 ◽  
pp. 125-130
Author(s):  
Minh Tam Nguyen ◽  
Phuc Thanh Nhan Nguyen ◽  
Thi Thuy Hang Nguyen
Keyword(s):  
High School ◽  
High School Students ◽  
University Students ◽  
Sleep Quality ◽  
Sleep Disturbances ◽  
Public Health Problem ◽  
Smartphone Addiction ◽  
Poor Sleep ◽  
School Students ◽  
The Relationship

The increasing use of smartphone among young people is creating negative effects and is an important public health problem in many countries. Smartphone abuse and addiction may cause physical and psychological disorders among users. However, the awarenes on this issue has been inadequate due to lacking of evidence. Objectives: To describe the current situation of smartphone using among students at highschools and universities in Hue city and to examine the relationship between smartphone using and sleep disturbances and psychological disstress among participants. Methods: A cross-sectional study with a randomly selected sample of 1,150 students at highschools and universities in Hue city. SAS-SV scale was used to evaluate phone addiction status, K10 scale was used for psychological distress assessment and PSQI scale was used to examine the sleep quality. Results: The proportion of students at highschools and universities having smartphones was 78.0%. The rate of smartphone addiction among high school students was 49.1% and that among university students was 43.7%. There was 57.3% of high school students had poor sleep quality, and that of university students was 51.6%. There was a statistically significant association between smartphone addiction and sleep disturbances and psychological disstress among participants (p <0.05). Conclusion: The prevalence of smartphone addiction among students at highschools and universities is alarming and is related to sleep disturbances and psychological disstress among participants. There is a strong call to develop intervention to help students to aware and manage the use of smartphone effectively.

scholarly journals Environmental enrichment prevents the late effect of acute stress-induced fear extinction deficit: the role of hippocampal AMPA-GluA1 phosphorylation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Leonardo Santana Novaes ◽  
Letícia Morais Bueno-de-Camargo ◽  
Carolina Demarchi Munhoz
Keyword(s):  
Environmental Enrichment ◽  
Basolateral Amygdala ◽  
Acute Stress ◽  
Fear Memory ◽  
Fear Extinction ◽  
Post Traumatic Stress ◽  
Related Disorder ◽  
Memory Extinction ◽  
Post Traumatic

AbstractThe persistence of anxiety and the deficit of fear memory extinction are both phenomena related to the symptoms of a trauma-related disorder, such as post-traumatic stress disorder (PTSD). Recently we have shown that single acute restraint stress (2 h) in rats induces a late anxiety-related behavior (observed ten days after stress), whereas, in the present work, we found that the same stress impaired fear extinction in animals conditioned ten days after stress. Fourteen days of environmental enrichment (EE) prevented the deleterious effect of stress on fear memory extinction. Additionally, we observed that EE prevented the stress-induced increase in AMPA receptor GluA1 subunit phosphorylation in the hippocampus, but not in the basolateral amygdala complex and the frontal cortex, indicating a potential mechanism by which it exerts its protective effect against the stress-induced behavioral outcome.

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