scholarly journals Evaluation of the Intel RealSense T265 for tracking natural human head motion

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Peter Hausamann ◽  
Christian B. Sinnott ◽  
Martin Daumer ◽  
Paul R. MacNeilage
Keyword(s):  
Gold Standard ◽  
Angular Position ◽  
Human Head ◽  
Clinical Diagnostics ◽  
Optical Tracking ◽  
Head Motion ◽  
Natural Environments ◽  
Standard Methods ◽  
Wide Range ◽  
Walking Speeds

AbstractAccurate and robust tracking of natural human head motion in natural environments is important for a number of applications including virtual and augmented reality, clinical diagnostics, as well as basic scientific research. IMU provide a versatile solution for recording inertial data including linear acceleration and angular velocity, but reconstructing head position is difficult or impossible. This problem can be solved by incorporating visual data using a technique known as visual-inertial simultaneous localization and mapping (VI-SLAM). A recently released commercial solution, the Intel RealSense T265, uses a proprietary VI-SLAM algorithm to estimate linear and angular position and velocity, but the performance of this device for tracking of natural human head motion in natural environments has not yet been comprehensively evaluated against gold-standard methods. In this study, we used a wide range of metrics to evaluate the performance of the T265 with different walking speeds in different environments, both indoor and outdoor, against two gold-standard methods, an optical tracking system and a so-called perambulator. Overall, we find that performance of the T265 relative to these gold-standard methods is most accurate for slow to normal walking speeds in small- to medium-sized environments. The suitability of this device for future scientific studies depends on the application; data presented here can be useful in making that determination.

scholarly journals Validation of the Intel RealSense T265 for Tracking Natural Human Head Motion

2021 ◽  
Author(s):  
Peter Hausamann ◽  
Christian Sinnott ◽  
Martin Daumer ◽  
Paul MacNeilage
Keyword(s):  
Gold Standard ◽  
Angular Position ◽  
Human Head ◽  
Clinical Diagnostics ◽  
Optical Tracking ◽  
Head Motion ◽  
Natural Environments ◽  
Standard Methods ◽  
Wide Range ◽  
Walking Speeds

Abstract Accurate and robust tracking of natural human head motion in natural environments is important for a number of applications including virtual and augmented reality, clinical diagnostics, as well as basic scientific research. Inertial measurement units (IMUs) provide a versatile solution for recording inertial data including linear acceleration and angular velocity, but reconstructing head position is difficult or impossible. This problem can be solved by incorporating visual data using a technique known as visual-inertial simultaneous localization and mapping (VI-SLAM). A recently released commercial solution, the Intel RealSense T265, uses VI-SLAM to estimate linear and angular position and velocity, but the performance of this device for tracking of natural human head motion in natural environments has not yet been comprehensively evaluated against gold-standard methods. In this study, we used a wide range of metrics to evaluate the performance of the T265 with different walking speeds in different environments, both indoor and outdoor, against two gold-standard methods, an optical tracking system and a so-called perambulator. Overall, we find that performance of the T265 relative to these gold-standard methods is most accurate for slow to normal walking speeds in small- to medium-sized environments. The suitability of this device for future scientific studies depends on the application; data presented here will be useful in making that determination.

scholarly journals INSPECTOR: free software for magnetic resonance spectroscopy data inspection, processing, simulation and analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Martin Gajdošík ◽  
Karl Landheer ◽  
Kelley M. Swanberg ◽  
Christoph Juchem
Keyword(s):  
Magnetic Resonance ◽  
Quality Management ◽  
Magnetic Resonance Spectroscopy ◽  
Data Processing ◽  
Biomedical Research ◽  
Clinical Diagnostics ◽  
Resonance Spectroscopy ◽  
User Friendliness ◽  
Wide Range

AbstractIn vivo magnetic resonance spectroscopy (MRS) is a powerful tool for biomedical research and clinical diagnostics, allowing for non-invasive measurement and analysis of small molecules from living tissues. However, currently available MRS processing and analytical software tools are limited in their potential for in-depth quality management, access to details of the processing stream, and user friendliness. Moreover, available MRS software focuses on selected aspects of MRS such as simulation, signal processing or analysis, necessitating the use of multiple packages and interfacing among them for biomedical applications. The freeware INSPECTOR comprises enhanced MRS data processing, simulation and analytical capabilities in a one-stop-shop solution for a wide range of biomedical research and diagnostic applications. Extensive data handling, quality management and visualization options are built in, enabling the assessment of every step of the processing chain with maximum transparency. The parameters of the processing can be flexibly chosen and tailored for the specific research problem, and extended confidence information is provided with the analysis. The INSPECTOR software stands out in its user-friendly workflow and potential for automation. In addition to convenience, the functionalities of INSPECTOR ensure rigorous and consistent data processing throughout multi-experiment and multi-center studies.

scholarly journals Tamoxifen and oxidative stress: an overlooked connection

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Nermin S. Ahmed ◽  
Marek Samec ◽  
Alena Liskova ◽  
Peter Kubatka ◽  
Luciano Saso
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Gold Standard ◽  
Pharmacological Activities ◽  
Standard Drug ◽  
Menopausal Women ◽  
Wide Range ◽  
Post Menopausal ◽  
Apoptotic Effects ◽  
And Oxidative Stress

AbstractTamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.

Beyond Bias: Critical Analysis and Layered Reading of Mao-Era Sources

2021 ◽  
Vol 29 (4) ◽  
pp. 759-782
Author(s):  
Sigrid Schmalzer
Keyword(s):  
Gold Standard ◽  
Critical Analysis ◽  
Source Material ◽  
The State ◽  
The Self ◽  
Wide Range ◽  
Layered Approach ◽  
Flea Markets ◽  
Mao Era

Abstract Scholars of Mao-era history adopt a wide range of approaches to the selection and treatment of source material. Some scholars regard published sources as propaganda, and therefore as biased and unreliable. For many, archival sources are the gold standard; others question the reliability even of the archive and favor materials that escaped the filtering fingers of the state to be found in flea markets or garbage piles. Avoiding the false choice of either accepting sources as received wisdom or dismissing them as biased, the author argues that how scholars read their sources is more important than which they keep and which they throw away. She advocates for a layered approach that accounts for contexts of production and circulation, and further emphasizes the need to make this process of reading sources visible in our writing. A critical, layered reading of three unlikely sources demonstrates the myriad possibilities for analysis that combines the empirical, the discursive, and the self-reflexive.

scholarly journals The Slow March toward Rapid Phenotypic Antimicrobial Susceptibility Testing: Are We There Yet?

2018 ◽  
Vol 56 (4) ◽  
pp. e01999-17 ◽  
Author(s):  
Christopher D. Doern
Keyword(s):  
Antimicrobial Susceptibility ◽  
Rapid Growth ◽  
Gold Standard ◽  
Historical Perspective ◽  
Susceptibility Testing ◽  
Turnaround Time ◽  
Antimicrobial Susceptibility Testing ◽  
Standard Methods ◽  
Phenotypic Susceptibility ◽  
Made In

ABSTRACT Antimicrobial susceptibility testing (AST) provides critical information for the management of patients with infections. The gold standard methods for assessing organism susceptibility are still based on growth and require incubation over relatively long periods of time. Until now, little progress has been made in developing rapid, growth-based, phenotypic AST systems. This commentary puts the recently FDA-cleared Accelerate PhenoTest (P. Pancholi et al., J Clin Microbiol 56:e01329-17, 2018, https://doi.org/10.1128/JCM.01329-17) in context by providing a historical perspective on attempts to accelerate phenotypic susceptibility results. In addition, some promising new innovations that promise to shorten the turnaround time for phenotypic AST will be briefly reviewed.

scholarly journals Real-time gaze estimation via pupil center tracking

2018 ◽  
Vol 9 (1) ◽  
pp. 6-18 ◽  
Author(s):  
Dario Cazzato ◽  
Fabio Dominio ◽  
Roberto Manduchi ◽  
Silvia M. Castro
Keyword(s):  
Real Time ◽  
Learning Algorithm ◽  
Natural Environments ◽  
Gaze Estimation ◽  
Head Pose ◽  
Data Set ◽  
Gaze Tracking ◽  
Illumination Changes ◽  
Wide Range ◽  
Estimation System

Abstract Automatic gaze estimation not based on commercial and expensive eye tracking hardware solutions can enable several applications in the fields of human computer interaction (HCI) and human behavior analysis. It is therefore not surprising that several related techniques and methods have been investigated in recent years. However, very few camera-based systems proposed in the literature are both real-time and robust. In this work, we propose a real-time user-calibration-free gaze estimation system that does not need person-dependent calibration, can deal with illumination changes and head pose variations, and can work with a wide range of distances from the camera. Our solution is based on a 3-D appearance-based method that processes the images from a built-in laptop camera. Real-time performance is obtained by combining head pose information with geometrical eye features to train a machine learning algorithm. Our method has been validated on a data set of images of users in natural environments, and shows promising results. The possibility of a real-time implementation, combined with the good quality of gaze tracking, make this system suitable for various HCI applications.

scholarly journals Directed Evolution of Aptamer Discovery Technologies

2021 ◽  
Author(s):  
Diana Wu ◽  
Chelsea Gordon ◽  
John Shin ◽  
Michael Eisenstein ◽  
Hyongsok Tom Soh
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Click Reaction ◽  
Clinical Diagnostics ◽  
High Quality ◽  
Affinity Reagents ◽  
Wide Range ◽  
Target Binding ◽  
Modified Nucleobases ◽  
Parallel Fashion

Although antibodies are a powerful tool for molecular biology and clinical diagnostics, there are many emerging applications for which nucleic acid-based aptamers can be advantageous. However, generating high-quality aptamers with sufficient affinity and specificity for biomedical applications is a challenging feat for most research laboratories. In this Account, we describe four techniques developed in our lab to accelerate the discovery of high quality aptamer reagents that can achieve robust binding even for challenging molecular targets. The first method is particle display, in which we convert solution-phase aptamers into aptamer particles that can be screened via fluorescence-activated cell sorting (FACS) to quantitatively isolate individual aptamer particles based on their affinity. This enables the efficient isolation of high-affinity aptamers in fewer selection rounds than conventional methods, thereby minimizing selection biases and reducing the emergence of artifacts in the final aptamer pool. We subsequently developed the multi-parametric particle display (MPPD) method, which employs two-color FACS to isolate aptamer particles based on both affinity and specificity, yielding aptamers that exhibit excellent target binding even in complex matrices like serum. The third method is a click chemistry-based particle display (click-PD) that enables the generation and high-throughput screening of non-nattural aptamers with a wide range of base modifications. We have shown that these base-modified aptamers can achieve robust affinity and specificity for targets that have proven challenging or inaccessible with natural nucleotide-based aptamer libraries. Lastly, we describe the non-natural aptamer array (N2A2) platform, in which a modified benchtop sequencing instrument is used to characterize base-modified aptamers in a massively parallel fashion, enabling the efficient identification of molecules with excellent affinity and specificity for their targets. This system first generates aptamer clusters on the flow-cell surface that incorporate alkyne-modified nucleobases, and then performs a click reaction to couple those nucleobases to an azide-modified chemical moiety. This yields a sequence-defined array of tens of millions of base-modified sequences, which can then be characterized in a high-throughput fashion. Collectively, we believe that these advancements are helping to make aptamer technology more accessible, efficient, and robust, thereby enabling the use of these affinity reagents for a wider range of molecular recognition and detection-based applications.

scholarly journals HeMoG: A White-Box Model to Unveil the Connection between Saliency Information and Human Head Motion in Virtual Reality

2021 ◽  
Author(s):  
Miguel Fabian Romero Rondon ◽  
Dario Zanca ◽  
Stefano Melacci ◽  
Marco Gori ◽  
Lucile Sassatelli
Keyword(s):  
Virtual Reality ◽  
Human Head ◽  
Box Model ◽  
Head Motion

Bacterial extracellular polysaccharides

1988 ◽  
Vol 34 (4) ◽  
pp. 415-420 ◽  
Author(s):  
Chris Whitfield
Keyword(s):  
Pathogenic Bacteria ◽  
Structural Information ◽  
Extracellular Polysaccharides ◽  
Natural Environments ◽  
Chemical Structures ◽  
Technological Advances ◽  
Wide Range ◽  
Surface Polysaccharides ◽  
Surface Location ◽  
Commercial Applications

The synthesis of extracellular polysaccharides has been recognized in certain bacterial cultures since the 1880s. It is now apparent that a wide range of bacteria produce these polymers and an equally wide range of chemical structures are possible. Their surface location, together with the range of available monosaccharide combinations, noncarbohydrate substituents, and linkage types, make extracellular polysaccharides excellent agents of diversity. As a result, much effort has been directed towards elucidating their structure in pathogenic bacteria and in enteric organisms in particular. Commercial applications of microbial polysaccharides have now broadened the scope of structural information. Most recently, technological advances in molecular biology have created the possibility of manipulating desired polymer characteristics, and with these advances, our knowledge of the mechanisms of synthesis and regulation of cell surface polysaccharides has improved. Ultimately more information regarding the function of extracellular polysaccharides in natural environments may result.

Analysis of Human Head Motion and Robotic Compensation for PET Imaging Studies

2021 ◽  
Author(s):  
Yangzhe Liu ◽  
Ti Wu ◽  
Iulian I. Iordachita ◽  
Caroline Paquette ◽  
Peter Kazanzides
Keyword(s):  
Pet Imaging ◽  
Human Head ◽  
Head Motion ◽  
Imaging Studies
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