scholarly journals Conductance artery stiffness impairs atrio-ventriculo-arterial coupling before manifestation of arterial hypertension or left ventricular hypertrophic remodelling

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kasper Kyhl ◽  
Sebastian von Huth ◽  
Annemie Bojer ◽  
Carsten Thomsen ◽  
Thomas Engstrøm ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Diastolic Function ◽  
Arterial Blood Pressure ◽  
Left Atrial ◽  
Aortic Distensibility ◽  
Arterial Blood ◽  
Artery Stiffness ◽  
Normal Ageing ◽  
Lv Diastolic Function

AbstractAs part of normal ageing, conductance arteries lose their cushion function, left ventricle (LV) filling and also left atrial emptying are impaired. The relation between conductance artery stiffness and LV diastolic function is normally explained by arterial hypertension and LV hypertrophy as needed intermediaries. We examined whether age-related aortic stiffening may influence LV diastolic function in normal healthy subjects. Aortic distensibility and pulse wave velocity (PWV) were related to LV emptying and filling parameters and left atrial emptying parameters as determined by magnetic resonance imaging in 36 healthy young (< 35 years) and 16 healthy middle-aged and elderly (> 35 years) with normal arterial blood pressure and myocardial mass. In the overall cohort, total aorta PWV correlated to a decrease in LV peak-emptying volume (r = 0.43), LV peak-filling (r = 0.47), passive atrial emptying volume (r = 0.66), and an increase in active atrial emptying volume (r = 0.47) (all p < 0.001). PWV was correlated to passive atrial emptying volume even if only the > 35-year-old were considered (r = 0.53; p < 0.001). Total peripheral resistance demonstrated similar correlations as PWV, but in a regression analysis only the total aorta PWV was related to left atrial (LA) passive emptying volume. Via impaired ventriculo-arterial coupling, the increased aortic PWV seen with normal ageing hence affects atrio-ventricular coupling, before increased aortic PWV is associated with significantly increased arterial blood pressure or LV hypertrophic remodelling. Our findings reinforce the existence of atrio-ventriculo-arterial coupling and suggest aortic distensibility should be considered an early therapeutic target to avoid diastolic dysfunction of the LV.

scholarly journals The status of element homeostasis in children and adolescents with essential arterial hypertension

2012 ◽  
Vol 93 (2) ◽  
pp. 184-190
Author(s):  
T P Makarova ◽  
Z R Khabibrakhmanova ◽  
D I Sadykova ◽  
Yu M Chilikina
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Blood Serum ◽  
Children And Adolescents ◽  
Arterial Blood Pressure ◽  
Childhood And Adolescence ◽  
Functional Variants ◽  
Arterial Blood ◽  
Essential Arterial Hypertension ◽  
Metabolic Type

Aim. To study the features of element homeostasis in children and adolescents with different variants of essential arterial hypertension. Methods. The clinical and functional variant of arterial hypertension was established based on the data of 24-hour monitoring of the arterial blood pressure. Investigation of the element content in the blood serum and daily urine was performed using the method of atomic absorption spectrophotometry. The clearance and the excreted fraction of the investigated elements were measured. Results. Revealed was an increase of the content of lead in the blood serum, an increase in lead excretion with urine, an increase in its clearance and excreted fraction in patients with stable arterial hypertension. It has been shown that for children and adolescents with a variety of clinical and functional variants of arterial hypertension characteristic is an excess of the serum content of a toxic element (lead) over the content of an essential element (zinc), and these changes are most pronounced in the group with stable arterial hypertension. In children and adolescents with the increase in arterial blood pressure registered was a decrease in the content of zinc and magnesium in the blood serum, whereas the disturbances of element homeostasis relate to the metabolic type. The increase in the content of copper and calcium in blood serum of patients with high blood pressure is also a manifestation of the metabolic type of element homeostasis disturbances. Conclusion. The increased level of lead in blood serum in combination with its enhanced excretion may be a cofactor in the development of essential arterial hypertension in childhood and adolescence.

scholarly journals Correlations between left ventricular and left atrial function assessed by speckle tracking echocardiography in patients with treated well-controlled arterial hypertension

2020 ◽  
Author(s):  
Beata Uziebło-Życzkowska ◽  
Paweł Krzesiński
Keyword(s):  
Arterial Hypertension ◽  
Diastolic Function ◽  
Left Atrial ◽  
Speckle Tracking ◽  
Longitudinal Strain ◽  
Speckle Tracking Echocardiography ◽  
Statistical Significance ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Lv Diastolic Function

Abstract BackgroundEven in patients with well-controlled arterial hypertension (AH) and without significant comorbidities left ventricular (LV) and left atrial (LA) strain abnormalities may sometimes be found in speckle-tracking echocardiography. Therefore, the aim of this study was to investigate the correlation between LA strain and LV diastolic and systolic function in a group of patients with treated, well-controlled AH.Methods LA contractile, conduit, and reservoir function, together with echocardiographic signs of LV diastolic function and LV global longitudinal strain (LV GLS), were assessed in 101 patients with treated, well-controlled AH who met the standard criteria of normal LV ejection fraction (LVEF) and normal LV diastolic function.ResultA relevant percentage of study participants presented lower than reference LV and LA strain values. Moreover, there were statistically significant differences in LA longitudinal strain (LAS) values (LAS during reservoir phase—LASr (p<0.001) and LAS during conduit phase—LAScd (p = 0.008)) between patients with high and lower LV GLS, confirmed by significant correlations between LASr, LAScd, and GLS. In the correlations analysis between LAS values and LV diastolic function parameters, statistical significance was obtained for the following: LASct (contraction) vs. e’avg, LASct vs. E/A, LASct vs. A, LAScd vs. e’avg, LAScd vs. E/A, and LAScd vs. A. Conclusions LV and LA strain abnormalities occurred within a significant percentage of patients with treated, well-controlledAH. Impaired LA strain is associated with lower LV strain and reduced LV diastolic function parameters, reflecting both the passive and active properties of the LA.

Systemic Haemodynamics in Mild Arterial Hypertension before and after Physical Training

1973 ◽  
Vol 45 (s1) ◽  
pp. 145s-149s ◽  
Author(s):  
R. Sannerstedt ◽  
H. Wasir ◽  
R. Henning ◽  
L. Werkö
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Arterial Hypertension ◽  
Arterial Blood Pressure ◽  
Physical Training ◽  
Blood Pressure Level ◽  
Work Load ◽  
Physical Conditioning ◽  
Arterial Blood ◽  
Before And After

1. Five men with borderline, latent arterial hypertension of the hyperkinetic type were studied haemodynamically at rest and during dynamic exercise before and after a 6-week period of supervised physical training. 2. Tendencies to lower heart rate, cardiac output and arterial blood pressure, both at rest and during a standardized work-load, were observed after the training period, with significant differences between paired observations for the heart rate and mean arterial blood pressure during exercise. The systemic vascular resistance being unchanged, there was a certain trend to an increased widening of the arteriovenous oxygen difference, both at rest and during exercise. 3. The present findings from a small number of subjects indicate that physical conditioning of patients with latent hypertension of the hyperkinetic type contributes to a normalization of their circulation toward a normokinetic one, thereby also normalizing their blood pressure level and achieving a more economic energy expenditure in the cardiovascular system.

scholarly journals INFLUENCE OF SHORT-TERM AIR POLLUTION WITH CARBON MONOXIDE ON THE RISK OF AMBULANCE CALL-OUTS RELATED TO ARTERIAL HYPERTENSION / TRUMPALAIKIS ORO TARŠOS ANGLIES MONOKSIDU POVEIKIS GREITOSIOS MEDICINOS PAGALBOS IŠKVIETIMŲ DĖL ARTERINĖS HIPERTENZIJOS RIZIKA

2015 ◽  
Vol 7 (4) ◽  
pp. 385-391 ◽  
Author(s):  
Agnė Brazienė ◽  
Jonė Venclovienė ◽  
Rūta Babarskienė ◽  
Tautvydė Danilčikaitė
Keyword(s):  
Blood Pressure ◽  
Air Pollution ◽  
Carbon Monoxide ◽  
Arterial Hypertension ◽  
Arterial Blood Pressure ◽  
Air Temperature ◽  
Negative Influence ◽  
Short Term ◽  
Arterial Blood ◽  
Negative Effect

Air pollution by carbon monoxide can be possibly related to the increase in arterial blood pressure and the risk of arterial hypertension. The study was made in Kaunas. The concentration of daily carbon monoxide was estimated according to the data provided by the Department of Environment of Kaunas and environmental monitoring stations of Kaunas city municipality. The study aims to determine a short-term impact of air pollution by carbon monoxide on the number of calls for ambulance due to the risk of arterial hypertension. The following factors were taken into consideration during the study: the time of calling for ambulance, seasons, weekdays and air temperature. Almost half of calls for ambulance (45.1%) due to the increase in arterial blood pressure were recorded in the afternoon (from 0 to 15 calls a day). The number of calls for ambulance due to the increase in arterial blood pressure was the lowest in the warmest time of the year (summer) regardless of the time of the day, and the highest in winter (in the afternoon and evening). The number of calls for ambulance at night due to the increase in arterial blood pressure was significantly higher on Mondays and Tuesdays. The number of calls for ambulance was 14% lower in the afternoon when the air temperature was 10 oC and 13% lower in the evening and at night. The number of calls for ambulance due to the increase in arterial blood pressure can be related to increased concentration of carbon monoxide one day before the call for ambulance (as a result of increased concentration of carbon monoxide by 1 mg/m3, the risk increases by 1.24 times). Increased concentration of carbon monoxide did not have negative influence on the number of calls for ambulance. Negative effect of carbon monoxide was observed when daily carbon concentration exceeded 80th percentile (0.583 mg/m3). Oro tarša anglies monoksidu, tikėtina, susijusi su arterinio kraujo spaudimo padidėjimu bei arterinės hipertenzijos išsivystymo rizika. Tyrimas atliktas Kaune, paros anglies monoksido koncentracija vertinta pagal Kauno regiono aplinkos apsaugos departamento ir miesto savivaldybės ekologinio monitoringo stotyse išmatuotus duomenis. Tyrimo tikslas – nustatyti trumpalaikį oro taršos anglies monoksidu poveikį greitosios medicinos pagalbos iškvietimų dėl arterinės hipertenzijos rizikai, atsižvelgiant į iškvietimo laiką ir kontroliuojant sezoniškumo, savaitės dienos bei oro temperatūros įtaką. Beveik pusė iškvietimų (45,1 %) dėl arterinio kraujo spaudimo padidėjimo buvo registruojami popietinėmis valandomis (nuo 0 iki 15 iškvietimų per parą). Šilčiausiu metų laiku (vasarą) iškvietimų skaičius dėl arterinio kraujospūdžio padidėjimo nepriklausomai nuo paros meto buvo mažiausias, o didžiausias – žiemą (po pietų ir vakare). Nakties metu iškvietimų rizika dėl padidėjusio arterinio kraujo spaudimo buvo žymiai didesnė pirmadieniais ir antradieniais. Iškvietimo parą oro temperatūrai pakilus 10 ºC greitosios medicinos pagalbos iškvietimų rizika buvo 14 % mažesnė popietinėmis valandomis bei 13 % mažesnė vakare ir naktį. Iškvietimų dėl padidėjusio arterinio kraujospūdžio ryte rizika sietina su padidėjusia anglies monoksido koncentracija parą prieš iškvietimą (padidėjus anglies monoksido koncentracijai 1 mg/m3, rizika padidėja 1,24 karto). Padidėjusi anglies monoksido koncentracija neigiamos įtakos iškvietimams neturėjo. Neigiamas anglies monoksido poveikis stebėtas paros koncentracijai viršijus 80 procentilių (0,583 mg/m3).

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