scholarly journals Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chihiro Nagase ◽  
Masaya Tanno ◽  
Hidemichi Kouzu ◽  
Takayuki Miki ◽  
Junichi Nishida ◽  
...  
Keyword(s):  
Risk Factor ◽  
Coronary Artery ◽  
Independent Risk Factor ◽  
Coronary Artery Stenosis ◽  
Multivariate Logistic Regression Analysis ◽  
Area Under The Curve ◽  
Artery Stenosis ◽  
Outcome Variable ◽  
Diabetic Patients ◽  
Secretory Capacity

AbstractMultiple factors regulate glucagon-like peptide-1 (GLP-1) secretion, but a group of apparently healthy subjects showed blunted responses of GLP-1 secretion in our previous study. In this study, we examined whether the reduction in GLP-1 secretory capacity is associated with increased extent of coronary artery stenosis in non-diabetic patients. Non-diabetic patients who were admitted for coronary angiography without a history of coronary interventions were enrolled. Coronary artery stenosis was quantified by Gensini score (GS), and GS ≥ 10 was used as an outcome variable based on its predictive value for cardiovascular events. The patients (mean age, 66.5 ± 8.8 years; 71% males, n = 173) underwent oral 75 g-glucose tolerant tests for determination of glucose, insulin and active GLP-1 levels. The area under the curve of plasma active GLP-1 (AUC-GLP-1) was determined as an index of GLP-1 secretory capacity. AUC-GLP-1 was not correlated with fasting glucose, AUC-glucose, serum lipids or indices of insulin sensitivity. In multivariate logistic regression analysis for GS ≥ 10, AUC-GLP-1 < median, age and hypertension were selected as explanatory variables, though fasting GLP-1 level was not selected. The findings suggest that reduction in GLP-1 secretory capacity is a novel independent risk factor of coronary stenosis.

scholarly journals Polymorphisms in the Glucagon-Like Peptide 1 Receptor (GLP-1R) Gene Are Associated with the Risk of Coronary Artery Disease in Chinese Han Patients with Type 2 Diabetes Mellitus: A Case-Control Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Xiaowei Ma ◽  
Ran Lu ◽  
Nan Gu ◽  
Xiaowei Wei ◽  
Ge Bai ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Chinese Han ◽  
Inheritance Mode ◽  
Glucagon Like Peptide 1 ◽  
Artery Disease

Background. Glucagon-like peptide 1 (GLP-1) bestows protective effects upon the cardiovascular system through direct cardiovascular interactions or by improvements to metabolic function. Both these effects are thought to be at least partly mediated by the GLP-1 receptor (GLP-1R). This case-controlled study investigated whether polymorphisms in theGLP-1Rgene affect the risk of cardiovascular disease in type 2 diabetic patients in the Chinese Han population.Methods. Eleven haplotype-tagging single nucleotide polymorphisms (SNPs), distributed across 22 kb of the 39 kbGLP-1Rgene, were selected and genotyped in diabetic patients from a Chinese Han population. Patients were classified based on the severity of coronary artery stenosis. Coronary artery stenosis was ≥50% in 394 patients (coronary artery disease- (CAD-) positive group), and coronary artery stenosis was <50% in 217 patients (control group). Allele and genotype frequencies were compared between the two groups at all 11 SNPs.Results. When considered in recessive inheritance mode, patients with the GG genotype at rs4714210 had a lower CAD risk than patients with other genotypes (OR = 0.442, 95% CI = 0.258–0.757,p=0.002), even when other known CAD risk factors were taken into account (ORa = 0.440, 95%CIa = 0.225–0.863,pa=0.017). In additive inheritance mode, GG genotype carriers at rs4714210 exhibited a lower risk of CAD than AA carriers (ORa = 0.475,CIa = 0.232–0.970,pa=0.041).Conclusion. In type 2 diabetic patients from a Han Chinese population, some variations in theGLP-1Rgene were associated with a lower risk of developing CAD.

Is Left Main Coronary Artery Stenosis a Risk Factor for Early Mortality in Coronary Artery Surgery?

2000 ◽  
Vol 15 (3) ◽  
pp. 217-222 ◽  
Author(s):  
M. Kamil Göl ◽  
Ibrahim Özsöyler ◽  
Erol Şener ◽  
Sabahattin Göksel ◽  
Ahmet Saritaş ◽  
...  
Keyword(s):  
Risk Factor ◽  
Coronary Artery ◽  
Left Main Coronary Artery ◽  
Coronary Artery Stenosis ◽  
Early Mortality ◽  
Artery Stenosis ◽  
Left Main ◽  
Coronary Artery Surgery ◽  
Main Coronary Artery Stenosis

Associations of Circulating microRNA-221 and 222 With the Severity of Coronary Artery Lesions in Acute Coronary Syndrome Patients

Angiology ◽  
2021 ◽  
pp. 000331972110342
Author(s):  
Xin Yu ◽  
Jian-feng Xu ◽  
Ming Song ◽  
Lei Zhang ◽  
Yi-hui Li ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Coronary Artery Stenosis ◽  
Quantitative Polymerase Chain Reaction ◽  
Area Under The Curve ◽  
Artery Stenosis ◽  
Circulating Microrna ◽  
Coronary Artery Lesions ◽  
Expression Levels ◽  
Coronary Syndrome

Circulating levels of microRNA-221 and 222 (miR-221/222) in patients with coronary artery disease (CAD) are elevated, yet the relationship between circulating miR-221/222 and the severity of coronary lesions in patients with acute coronary syndrome (ACS) remains unknown. In this study, the relative expression levels of circulating miR-221/222 in patients with ACS (n = 267) and controls (n = 71) were compared by real-time fluorescence quantitative-polymerase chain reaction (RT-qPCR). The ACS group was further divided into unstable angina pectoris (UA) group (n = 191) and acute myocardial infarction (AMI) group (n = 76). Significant upregulation of circulating miR-221/222 was observed in ACS. A positive linear correlation between circulating miR-221/222 and Gensini scores was demonstrated. The area under the curve (AUC) of circulating miR-221/222 in the diagnosis of coronary artery stenosis ≥50% was 0.605 and 0.643, respectively. The circulating miRNA-221/222 expression levels in ACS patients were elevated and positively associated with the severity of the coronary artery lesions. Circulating miR-221/222 may be novel biomarkers for the diagnosis of coronary artery stenosis ≥50% and the occurrence of ACS.

scholarly journals ACE I/D and AT1 1166A/C Polymorphism as a Risk Factor for Coronary Artery Stenosis in Kawasaki Disease

2003 ◽  
Vol 53 (1) ◽  
pp. 166-166
Author(s):  
Ryuji Fukazawa ◽  
Tomoyoshi Sonobe ◽  
Kenji Hamaoka ◽  
Kunihiro Hamamoto ◽  
Yohko Uchikoba ◽  
...  
Keyword(s):  
Risk Factor ◽  
Coronary Artery ◽  
Kawasaki Disease ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis

scholarly journals Association of Coronary Artery Stenosis with Carotid Atherosclerosis in Asymptomatic Type 2 Diabetic Patients

2011 ◽  
Vol 18 (4) ◽  
pp. 337-344 ◽  
Author(s):  
Yoko Irie ◽  
Kenya Sakamoto ◽  
Fumiyo Kubo ◽  
Takahiro Okusu ◽  
Takashi Katura ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Carotid Atherosclerosis ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Trimethylamine N-Oxide is Associated with Heart Failure Risk in Patients with Preserved Ejection Fraction

2020 ◽  
Author(s):  
Zengxiang Dong ◽  
Sijia Zheng ◽  
Zhaoqian Shen ◽  
Yingchun Luo ◽  
Xin Hai
Keyword(s):  
Heart Failure ◽  
Risk Factor ◽  
Ejection Fraction ◽  
Plasma Levels ◽  
Independent Risk Factor ◽  
Multivariate Logistic Regression Analysis ◽  
Area Under The Curve ◽  
Preserved Ejection Fraction ◽  
The Relationship ◽  
Biochemical Examination

Abstract Background Trimethylamine N-oxide (TMAO) has been considered to be an independent risk factor of heart failure (HF). Objectives To further determine the plasma levels of TMAO in patients who have HF with preserved ejection fraction (HFpEF), and to analyze the relationship between TMAO and HFpEF risk. Methods A total of 57 control participants and 61 patients with HFpEF were recruited. We measured and analyzed plasma levels of TMAO and performed biochemical examination of all patients. Results The mean (SD) plasma levels of TMAO in patients with HFpEF (6.84 [1.12] μmol/L) were significantly higher than in controls (1.63 [0.08] μmol/L; P &lt;.01). The area under the curve (AUC) of TMAO and N-terminal pro b-type natriuretic peptide (NT-proBNP) was 0.817 and 0.924, respectively, which were determined by receiver operating characteristic (ROC) analysis. TMAO was an independent risk factor in patients with HFpEF, as revealed by univariate and multivariate logistic regression analysis. The level of TMAO was correlated with blood urea nitrogen (BUN), creatinine, and NT-proBNP. Conclusions TMAO level was highly associated with HFpEF risk.

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