scholarly journals Genome-wide identification, evolution, and transcript profiling of Aldehyde dehydrogenase superfamily in potato during development stages and stress conditions

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Md. Sifatul Islam ◽  
Md. Soyib Hasan ◽  
Md. Nazmul Hasan ◽  
Shamsul H. Prodhan ◽  
Tahmina Islam ◽  
...  
Keyword(s):  
Aldehyde Dehydrogenase ◽  
Gene Expression Analysis ◽  
Evolutionary Analysis ◽  
Functional Studies ◽  
Cofactor Binding ◽  
Genome Wide ◽  
Comprehensive Information ◽  
A Genome ◽  
Aldehyde Dehydrogenase Superfamily ◽  
Genome Wide Study

AbstractThe Aldehyde dehydrogenase (ALDH) superfamily comprises a group of enzymes involved in the scavenging of toxic aldehyde molecules by converting them into their corresponding non-toxic carboxylic acids. A genome-wide study in potato identified a total of 22 ALDH genes grouped into ten families that are presented unevenly throughout all the 12 chromosomes. Based on the evolutionary analysis of ALDH proteins from different plant species, ALDH2 and ALDH3 were found to be the most abundant families in the plant, while ALDH18 was found to be the most distantly related one. Gene expression analysis revealed that the expression of StALDH genes is highly tissue-specific and divergent in various abiotic, biotic, and hormonal treatments. Structural modelling and functional analysis of selected StALDH members revealed conservancy in their secondary structures and cofactor binding sites. Taken together, our findings provide comprehensive information on the ALDH gene family in potato that will help in developing a framework for further functional studies.

scholarly journals Genome-wide study of methotrexate clearance replicates SLCO1B1

Blood ◽  
2013 ◽  
Vol 121 (6) ◽  
pp. 898-904 ◽  
Author(s):  
Laura B. Ramsey ◽  
John C. Panetta ◽  
Colton Smith ◽  
Wenjian Yang ◽  
Yiping Fan ◽  
...  
Keyword(s):  
Genetic Variations ◽  
Genome Wide ◽  
A Genome ◽  
Key Points ◽  
Genome Wide Study

Key Points A genome-wide study of the association of over 5 million SNPs with methotrexate clearance in 1279 patients treated with HDMTX in multicenter COG trials 9904 and 9905. We replicated the finding that inherited variations in SLCO1B1 are the most important genetic variations influencing methotrexate clearance.

scholarly journals A genome-wide study of de novo deletions identifies a candidate locus for non-syndromic isolated cleft lip/palate risk

BMC Genetics ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 24 ◽  
Author(s):  
Samuel G Younkin ◽  
Robert B Scharpf ◽  
Holger Schwender ◽  
Margaret M Parker ◽  
Alan F Scott ◽  
...  
Keyword(s):  
Cleft Lip ◽  
De Novo ◽  
Candidate Locus ◽  
Genome Wide ◽  
A Genome ◽  
Cleft Lip Palate ◽  
Genome Wide Study

scholarly journals A Genome-Wide Comparative Evolutionary Analysis of Herpes Simplex Virus Type 1 and Varicella Zoster Virus

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e22527 ◽  
Author(s):  
Peter Norberg ◽  
Shaun Tyler ◽  
Alberto Severini ◽  
Rich Whitley ◽  
Jan-Åke Liljeqvist ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Herpes Simplex Virus Type ◽  
Evolutionary Analysis ◽  
Varicella Zoster ◽  
Genome Wide ◽  
A Genome ◽  
Simplex Virus

scholarly journals Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome

2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Thomas M Morgan ◽  
John A House ◽  
Sharon Cresci ◽  
Philip Jones ◽  
Hooman Allayee ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Syndrome ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Study

scholarly journals A Genome-Wide Study of Cytogenetic Changes in Colorectal Cancer Using SNP Microarrays: Opportunities for Future Personalized Treatment

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31968 ◽  
Author(s):  
Farzana Jasmine ◽  
Ronald Rahaman ◽  
Charlotte Dodsworth ◽  
Shantanu Roy ◽  
Rupash Paul ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Personalized Treatment ◽  
Genome Wide ◽  
A Genome ◽  
Snp Microarrays ◽  
Cytogenetic Changes ◽  
Genome Wide Study

scholarly journals Chromatin architectural proteins regulate flowering time by precluding gene looping

2021 ◽  
Vol 7 (24) ◽  
pp. eabg3097
Author(s):  
Bo Zhao ◽  
Yanpeng Xi ◽  
Junghyun Kim ◽  
Sibum Sung
Keyword(s):  
Chromatin Structure ◽  
Cellular Processes ◽  
Genome Wide ◽  
A Genome ◽  
Evolutionarily Conserved ◽  
Architectural Proteins ◽  
Floral Repressor ◽  
Flanking Regions ◽  
Genome Wide Study

Chromatin structure is critical for gene expression and many other cellular processes. In Arabidopsis thaliana, the floral repressor FLC adopts a self-loop chromatin structure via bridging of its flanking regions. This local gene loop is necessary for active FLC expression. However, the molecular mechanism underlying the formation of this class of gene loops is unknown. Here, we report the characterization of a group of linker histone-like proteins, named the GH1-HMGA family in Arabidopsis, which act as chromatin architecture modulators. We demonstrate that these family members redundantly promote the floral transition through the repression of FLC. A genome-wide study revealed that this family preferentially binds to the 5′ and 3′ ends of gene bodies. The loss of this binding increases FLC expression by stabilizing the FLC 5′ to 3′ gene looping. Our study provides mechanistic insights into how a family of evolutionarily conserved proteins regulates the formation of local gene loops.

scholarly journals A Genome-Wide Study of Moyamoya-Type Cerebrovascular Disease in the Korean Population

2011 ◽  
Vol 50 (6) ◽  
pp. 486 ◽  
Author(s):  
Sung-Pil Joo ◽  
Tae Sun Kim ◽  
Il-Kwon Lee ◽  
Joon-Tae Kim ◽  
Man-Seok Park ◽  
...  
Keyword(s):  
Cerebrovascular Disease ◽  
Korean Population ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Study
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