Plasma leptin is associated with insulin resistance independent of age, body mass index, fat mass, lipids, and pubertal development in nondiabetic adolescents

2004 ◽  
Vol 28 (4) ◽  
pp. 470-475 ◽  
Author(s):  
K-C Huang ◽  
R C Y Lin ◽  
N Kormas ◽  
L-T Lee ◽  
C-Y Chen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Mass ◽  
Fat Mass ◽  
Pubertal Development ◽  
Plasma Leptin

scholarly journals Lipoprotein Metabolism, Insulin Resistance, and Adipocytokine Levels in Japanese Female Adolescents With a Normal Body Mass Index and High Body Fat Mass

2009 ◽  
Vol 73 (3) ◽  
pp. 534-539 ◽  
Author(s):  
Noriaki Kishimoto ◽  
Koichi Okita ◽  
Shingo Takada ◽  
Ichiro Sakuma ◽  
Yasuaki Saijo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Lipoprotein Metabolism ◽  
Female Adolescents ◽  
Normal Body Mass Index ◽  
Body Fat Mass ◽  
Japanese Female

Cardiometabolic Risks Among Survivors of Childhood Hematologic Malignancies.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 4113-4113
Author(s):  
Daniel A. Mulrooney ◽  
Aaron Kelly ◽  
K. Scott Baker ◽  
Lyn Steffen ◽  
Jill Lunsford-Lee ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Carotid Artery ◽  
Body Mass ◽  
Visceral Fat ◽  
Fasting Glucose ◽  
Lymphoblastic Leukemia ◽  
Pubertal Development ◽  
Hematologic Malignancies ◽  
Increased Risk

Abstract Abstract 4113 Survival rates for childhood hematologic malignancies continue to improve. Research suggests these individuals are at increased risk for late adverse cardiovascular outcomes. This analysis includes children (n=101) who survived ≥ 5-yrs following diagnosis of acute lymphoblastic leukemia (ALL) (n=78), acute myeloid leukemia (AML) (n=5), and non-Hodgkin lymphoma (NHL) (n=18), compared to their frequency matched healthy siblings (n=123). Anthropometric measurements, blood pressure (BP), fasting glucose, insulin, and lipids were collected; insulin resistance was assessed by euglycemic hyperinsulinemic clamp, adjusted for lean body mass (low Mlbm represents insulin resistance); carotid artery stiffness (distensibility and compliance – low levels represent increased stiffness), adjusted for lumen diameter, was assessed by ultrasound. Least squares means and standard errors, adjusted for age, gender, pubertal development, and body mass index (BMI) were compared. Survivors (63.4% male) mean age at diagnosis was 10.3 yrs (5.7-15.8) and 15.0 yrs (9.9-17.9) at evaluation; siblings (56.1% male) were 13.6 yrs (9.0-18.0) at evaluation. Among survivors, 88 (87.1%) received chemotherapy only and 13 (12.9%) chemotherapy and cranial radiation. Metabolic syndrome (MS) (modified criteria for children) was present in 8 (7.9%) survivors vs. 6 (4.9%) siblings (p=0.35). Nevertheless, 25 (24.8 %) survivors had two or more MS components compared to 17 (13.8 %) siblings (p=0.04). There were no differences between cases and siblings on measures of adiposity (BMI, waist circumference, % body fat, visceral fat), BP, fasting glucose, insulin, and lipids. However, survivors were significantly more insulin resistant and had stiffer carotid arteries compared to controls (Table). Despite similar levels of adiposity, survivors of childhood hematologic malignancies demonstrate signs of insulin resistance and increased vascular stiffness at a young age compared to healthy controls. These findings highlight: 1) the heightened cardiovascular risk profile among children who survived hematologic malignancies and 2) that the typical components of the MS may not be sufficiently sensitive measures of risk in this young population. Survivors (n = 101) Siblings (n = 123) (p) LS means (SE) LS means (SE) Body mass index (BMI) (kg/m2) 21.3 (0.5) 21.2 (0.5) 0.8 Visceral fat (cm3) 22.8 (1.0) 22.3 (1.0) 0.7 Insulin resistance [Mlbm (mg/kg/min)] 12.6 (0.5) 14.2 (0.5) 0.007 Carotid artery distensibility (%) 13.5 (0.4) 14.9 (0.4) 0.004 Carotid artery compliance (mm2/mmHg) 0.16 (0.004) 0.17 (0.004) 0.008 Disclosures: No relevant conflicts of interest to declare.

Plasma Obestatin Concentrations Are Negatively Correlated with Body Mass Index, Insulin Resistance Index, and Plasma Leptin Concentrations in Obesity and Anorexia Nervosa

2008 ◽  
Vol 64 (3) ◽  
pp. 252-255 ◽  
Author(s):  
Toshihiro Nakahara ◽  
Toshiro Harada ◽  
Daisuke Yasuhara ◽  
Nobuhiro Shimada ◽  
Haruka Amitani ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Anorexia Nervosa ◽  
Body Mass ◽  
Resistance Index ◽  
Insulin Resistance Index ◽  
Plasma Leptin

scholarly journals Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3–4 chronic kidney disease patients

2007 ◽  
Vol 86 (6) ◽  
pp. 1642-1648 ◽  
Author(s):  
M Luisa Trirogoff ◽  
Ayumi Shintani ◽  
Jonathan Himmelfarb ◽  
T Alp Ikizler
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Body Mass ◽  
Fat Mass

scholarly journals Plasma Leptin Levels in Healthy Children and Adolescents: Dependence on Body Mass Index, Body Fat Mass, Gender, Pubertal Stage, and Testosterone*

1997 ◽  
Vol 82 (9) ◽  
pp. 2904-2910 ◽  
Author(s):  
Werner F. Blum ◽  
Piera Englaro ◽  
Sigrid Hanitsch ◽  
Anders Juul ◽  
Niels T. Hertel ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Children And Adolescents ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Healthy Children ◽  
Pubertal Stage ◽  
Plasma Leptin

Structural and Functional State of the Heart in Hypertension, Depending on Body Mass Index and the Presence of Insulin Resistance

2019 ◽  
Vol 4 (6) ◽  
pp. 150-156
Author(s):  
M. M. Kochuieva ◽  
◽  
V. G. Psarova ◽  
N. M. Kyrychenko ◽  
L. A. Ruban ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Mass ◽  
Functional State
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