scholarly journals Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma-derived cell lines and normal human tissues

Oncogene ◽  
1998 ◽  
Vol 16 (25) ◽  
pp. 3243-3252 ◽  
Author(s):  
Hakjoo Lee ◽  
Nita J Maihle
Keyword(s):  
Ovarian Carcinoma ◽  
Cell Lines ◽  
Human Tissues ◽  
Isolation And Characterization ◽  
Normal Human

Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: Growth features and cytogenetics

1993 ◽  
Vol 53 (4) ◽  
pp. 613-620 ◽  
Author(s):  
Cornelia A. M. van den Berg-Bakker ◽  
Anne Hagemeijer ◽  
Elsa M. Franken-Postma ◽  
Vincent T. H. B. M. Smit ◽  
Peter J. K. Kuppen ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Ovarian Carcinoma ◽  
Cell Line ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Tumor Cell Line ◽  
Carcinoma Cell Lines ◽  
Growth Features

Isolation and characterization of conditionally immortalized astrocyte cell lines derived from adult human spinal cord

Glia ◽  
1994 ◽  
Vol 10 (3) ◽  
pp. 211-226 ◽  
Author(s):  
Scott R. Whittemore ◽  
Joseph T. Neary ◽  
Naomi Kleitman ◽  
Henry R. Sanon ◽  
Adelaida Benigno ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Lines ◽  
Human Spinal Cord ◽  
Adult Human ◽  
Isolation And Characterization

Isolation and Characterization of Mesoangioblasts from Mouse, Dog, and Human Tissues

2007 ◽  
Vol 3 (1) ◽  
Author(s):  
Rossana Tonlorenzi ◽  
Arianna Dellavalle ◽  
Esther Schnapp ◽  
Giulio Cossu ◽  
Maurilio Sampaolesi
Keyword(s):  
Human Tissues ◽  
Isolation And Characterization

Identification of Papilloma-Like Virus Particles in Cell Lines Derived from Green Sea Turtle (Chelonia Mydas) With Fibropapilloma

1998 ◽  
Vol 4 (S2) ◽  
pp. 1158-1159
Author(s):  
Yuanan Lu ◽  
Vivek R. Nerurkar ◽  
Tina M. Weatherby ◽  
Richard Yanagihara
Keyword(s):  
Cell Lines ◽  
Soft Tissues ◽  
Chelonia Mydas ◽  
Sea Turtle ◽  
Green Sea Turtle ◽  
Virus Particles ◽  
Green Sea Turtles ◽  
Multiple Organs ◽  
Isolation And Characterization

The near epidemic occurrence of fibropapilloma in green sea turtle (Chelonia my das) (Figure 1) significantly threatens the survival of this species which is protected under the U.S. Endangered Species Act. Although collective evidence suggests a viral etiology, the causative virus of green sea turtle fibropapilloma has not been isolated. To facilitate the isolation and characterization of the causative virus(es), we established 13 cell lines from multiple organs/tissues (tumor, kidney, lung, heart, gall bladder, testis, and skin) of green sea turtles with fibropapilloma. Serial subcultivation of cell lines derived from lungs, testis, eye soft tissues and tumors resulted in the formation of tumor-like aggregates, which attained sizes of 1-2 mm in diameter within two weeks (Figure 2). Media from such cultures, when inoculated onto cells derived from healthy turtle embryos, produced similar tumor-like aggregates, suggesting the presence of a transmissible agent.

scholarly journals Design, Synthesis, and Structural Characterization of Novel Diazaphenothiazines with 1,2,3-Triazole Substituents as Promising Antiproliferative Agents

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4388 ◽  
Author(s):  
Morak-Młodawska ◽  
Pluta ◽  
Latocha ◽  
Jeleń ◽  
Kuśmierz
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Human Fibroblasts ◽  
Human Tumor ◽  
Design Synthesis ◽  
Human Tumor Cell Lines ◽  
Ic50 Values ◽  
Normal Human ◽  
Low Cytotoxicity

A series of novel 1,2,3-triazole-diazphenothiazine hybrids was designed, synthesized, and evaluated for anticancer activity against four selected human tumor cell lines (SNB-19, Caco-2, A549, and MDA-MB231). The majority of the synthesized compounds exhibited significant potent activity against the investigated cell lines. Among them, compounds 1d and 4c showed excellent broad spectrum anticancer activity, with IC50 values ranging from 0.25 to 4.66 μM and 0.25 to 6.25 μM, respectively. The most promising compound 1d, possessing low cytotoxicity against normal human fibroblasts NHFF, was used for gene expression analysis using reverse transcription–quantitative real-time PCR (RT–qPCR). The expression of H3, TP53, CDKN1A, BCL-2, and BAX genes revealed that these compounds inhibited the proliferation in all cells (H3) and activated mitochondrial events of apoptosis (BAX/BCL-2).

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