scholarly journals A Novel PET Imaging Probe for the Detection and Monitoring of Translocator Protein 18 kDa Expression in Pathological Disorders

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mara Perrone ◽  
Byung Seok Moon ◽  
Hyun Soo Park ◽  
Valentino Laquintana ◽  
Jae Ho Jung ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Translocator Protein ◽  
Imaging Probe ◽  
Translocator Protein 18 Kda

scholarly journals PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease Using N-(2,5-Dimethoxybenzyl)-2-18F-Fluoro-N-(2-Phenoxyphenyl)Acetamide

2015 ◽  
Vol 56 (2) ◽  
pp. 311-316 ◽  
Author(s):  
M. L. James ◽  
N. P. Belichenko ◽  
T.-V. V. Nguyen ◽  
L. E. Andrews ◽  
Z. Ding ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Pet Imaging ◽  
Translocator Protein ◽  
Model Of Alzheimer’S Disease ◽  
Translocator Protein 18 Kda

scholarly journals Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases

2017 ◽  
Vol 18 (4) ◽  
pp. 785 ◽  
Author(s):  
Anne-Claire Dupont ◽  
Bérenger Largeau ◽  
Maria Santiago Ribeiro ◽  
Denis Guilloteau ◽  
Claire Tronel ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Neurodegenerative Diseases ◽  
Pet Imaging ◽  
Clinical Impact ◽  
Translocator Protein ◽  
Emission Tomography ◽  
Positron Emission ◽  
Translocator Protein 18 Kda

scholarly journals PET Imaging of Lung Inflammation with [18F]FEDAC, a Radioligand for Translocator Protein (18 kDa)

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45065 ◽  
Author(s):  
Akiko Hatori ◽  
Joji Yui ◽  
Tomoteru Yamasaki ◽  
Lin Xie ◽  
Katsushi Kumata ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Lung Inflammation ◽  
Translocator Protein ◽  
Translocator Protein 18 Kda

scholarly journals Fully Automated Synthesis of Novel TSPO PET Imaging Ligand [18F]Fluoroethyltemazepam

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2372
Author(s):  
Dario Fiorenza ◽  
Emanuele Nicolai ◽  
Carlo Cavaliere ◽  
Ferdinando Fiorino ◽  
Giovanna Esposito ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Benzodiazepine Receptor ◽  
Translocator Protein ◽  
One Pot ◽  
Synthesis Time ◽  
Future Production ◽  
Positron Emission ◽  
Activity Yield ◽  
Translocator Protein 18 Kda ◽  
Tlc Analysis

Introduction: Benzodiazepines, including temazepam are described as TSPO antagonists. In fact, TSPO was initially described as a peripheral benzodiazepine receptor (PBR) with a secondary binding site for diazepam. TSPO is a potential imaging target of neuroinflammation because there is an amplification of the expression of this receptor. Objectives: Herein, we developed a novel fluorinated benzodiazepine ligand, [18F]Fluoroethyltemazepam ([18F]F-FETEM), for positron emission tomography (PET) imaging of translocator protein (18 kDa). Methods: [18F]F-FETEM was radiolabelled with an automated synthesizer via a one-pot procedure. We conducted a [18F]F-aliphatic nucleophilic substitution of a tosylated precursor followed by purification on C18 and Alumina N SPE cartridges. Quality control tests was also carried out. Results: We obtained 2.0–3.0% decay-uncorrected radiochemical activity yield (3.7% decay-corrected) within the whole synthesis time about 33 min. The radiochemical purity of [18F]F-FETEM was over 90% by TLC analysis. Conclusion: This automated procedure may be used as basis for future production of [18F]F-FETEM for preclinical PET imaging studies.

Mapping of Translocator Protein (18 kDa) in Peripheral Sterile Inflammatory Disease and Cancer through PET Imaging

2021 ◽  
Vol 18 (4) ◽  
pp. 1507-1529
Author(s):  
Anupriya Adhikari ◽  
Priya Singh ◽  
Kamalesh S Mahar ◽  
Manish Adhikari ◽  
Bhawana Adhikari ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Inflammatory Disease ◽  
Translocator Protein ◽  
Translocator Protein 18 Kda

Structural and Functional Evolution of the Translocator Protein (18 kDa)

2012 ◽  
Vol 12 (4) ◽  
pp. 369-386 ◽  
Author(s):  
J. Fan ◽  
P. Lindemann ◽  
M. G.J. Feuilloley ◽  
V. Papadopoulos
Keyword(s):  
Translocator Protein ◽  
Functional Evolution ◽  
Translocator Protein 18 Kda

The Translocator Protein 18 kDa (TSPO) and Its Role in Mitochondrial Biology and Psychiatric Disorders

2015 ◽  
Vol 15 (5) ◽  
pp. 366-372 ◽  
Author(s):  
Vladimir Milenkovic ◽  
Rainer Rupprecht ◽  
Christian Wetzel
Keyword(s):  
Psychiatric Disorders ◽  
Translocator Protein ◽  
Translocator Protein 18 Kda

scholarly journals Translocator Protein PET Imaging for Glial Activation in Multiple Sclerosis

2010 ◽  
Vol 6 (3) ◽  
pp. 354-361 ◽  
Author(s):  
Unsong Oh ◽  
Masahiro Fujita ◽  
Vasiliki N. Ikonomidou ◽  
Iordanis E. Evangelou ◽  
Eiji Matsuura ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pet Imaging ◽  
Glial Activation ◽  
Translocator Protein
Sign in / Sign up

Export Citation Format

Share Document