scholarly journals Jolkinolide B induces apoptosis and inhibits tumor growth in mouse melanoma B16F10 cells by altering glycolysis

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Caixia Gao ◽  
Xinyan Yan ◽  
Bo Wang ◽  
Lina Yu ◽  
Jichun Han ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Mouse Melanoma ◽  
B16f10 Cells ◽  
Melanoma B16f10

Isoliquiritigenin Inhibits Proliferation and Induces Apoptosis via Alleviating Hypoxia and Reducing Glycolysis in Mouse Melanoma B16F10 Cells

2016 ◽  
Vol 11 (2) ◽  
pp. 215-227 ◽  
Author(s):  
Yanming Wang ◽  
Jun Ma ◽  
Xinyan Yan ◽  
Xiaoyu Chen ◽  
Lingling Si ◽  
...  
Keyword(s):  
Mouse Melanoma ◽  
B16f10 Cells ◽  
Melanoma B16f10

scholarly journals Suppression of tumor growth and metastasis by ethanol extract of Angelica dahurica Radix in murine melanoma B16F10 cells

2020 ◽  
Vol 14 (1) ◽  
pp. 23-34
Author(s):  
Hyun Hwangbo ◽  
Eun Ok Choi ◽  
Min Yeong Kim ◽  
Da Hye Kwon ◽  
Seon Yeong Ji ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Ethanol Extract ◽  
Angelica Dahurica ◽  
Murine Melanoma ◽  
B16f10 Cells ◽  
Melanoma B16f10 ◽  
Tumor Growth And Metastasis

scholarly journals Sarcophine-Diol Inhibits Expression of COX-2, Inhibits Activity of cPLA2, Enhances Degradation of PLA2 and PLCγ1 and Inhibits Cell Membrane Permeability in Mouse Melanoma B16F10 Cells

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 2166-2180 ◽  
Author(s):  
Pawel T. Szymanski ◽  
Pratik Muley ◽  
Safwat A. Ahmed ◽  
Sherief Khalifa ◽  
Hesham Fahmy
Keyword(s):  
Cell Membrane ◽  
Membrane Permeability ◽  
Cell Membrane Permeability ◽  
Mouse Melanoma ◽  
B16f10 Cells ◽  
Melanoma B16f10 ◽  
Cox 2

Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells

2013 ◽  
Vol 35 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Kil-Nam Kim ◽  
Ginnae Ahn ◽  
Soo-Jin Heo ◽  
Sung-Myung Kang ◽  
Min-Cheol Kang ◽  
...  
Keyword(s):  
Tumor Growth ◽  
B16f10 Cells ◽  
Melanoma B16f10 ◽  
Inhibition Of Tumor Growth

scholarly journals Recombinant human PRAME immunization reducesPRAME-expressing tumor growth in mice

2018 ◽  
Vol 17 (3) ◽  
pp. 36-42
Author(s):  
Yu. P. Finashutina ◽  
N. A. Lyzhko ◽  
N. N. Kasatkina ◽  
L. A. Kesaeva ◽  
V. V. Tikhonova ◽  
...  
Keyword(s):  
Recombinant Protein ◽  
Tumor Volume ◽  
High Titer ◽  
Mouse Melanoma ◽  
B16f10 Cells ◽  
Gene Coding ◽  
Melanoma B16f10 ◽  
Tumor Types ◽  
Human Recombinant Protein ◽  
Immunization Series

Intrоduction.Human antigen PRAME is preferentially expressed in a number of different tumor types and may be a potent target for anti-tumor immunotherapy.Purpose.To study anti-tumor action of immunogenic mix recombinant PRAME protein and adjuvant in mice with innate immunity.Materials and methods.C57BL/6 female mice were used for immunization with purified human recombinant protein PRAME. Human PRAME gene coding sequence was cloned in mammalian expressing vector pCEP4 and resulting plasmid was introduced in mouse melanoma B16F10 cells by transfection followed by RQ-PCR, Western blot and flow-cytometry analysis. Then stably PRAME-transfected melanoma cells were injected in mice.Results.The mouse melanoma B16F10 cells stably expressing human PRAME protein were obtained. We demonstrate the 10-fold decreased tumor volume in mice with melanoma B16F10 expressing human PRAME after preventive immunization series with recombinant PRAME protein. The tumor volume reducing was correlated with high titer (6.14 × 10 5) of anti-PRAME antibodies in mice sera.Conclusion.These data indicate that recombinant protein PRAME is immunogenic and may be a potent antigen for immunotherapuetics studies.

Transforming growth factor-β1 inhibits tumor growth in a mouse melanoma model by down-regulating the plasminogen activation system

2003 ◽  
Vol 291 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Laurent Ramont ◽  
Sylvie Pasco ◽  
William Hornebeck ◽  
François-Xavier Maquart ◽  
Jean Claude Monboisse
Keyword(s):  
Growth Factor ◽  
Tumor Growth ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Plasminogen Activation ◽  
Mouse Melanoma ◽  
Plasminogen Activation System ◽  
Activation System ◽  
Mouse Melanoma Model ◽  
Melanoma Model

Abstract A79: Inhibition of p53-MDM2 protein interaction reduces tumor growth in a mouse melanoma model

2020 ◽  
Author(s):  
Katrine Ingelshed ◽  
Danai Lianoudaki ◽  
Dilraj Lama ◽  
Silke Sohn ◽  
Nicolas Fritz ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Protein Interaction ◽  
Mdm2 Protein ◽  
Mouse Melanoma ◽  
Mouse Melanoma Model ◽  
Melanoma Model

scholarly journals Unveiling the Differential Antioxidant Activity of Maslinic Acid in Murine Melanoma Cells and in Rat Embryonic Healthy Cells Following Treatment with Hydrogen Peroxide

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 4020
Author(s):  
Khalida Mokhtari ◽  
Amalia Pérez-Jiménez ◽  
Leticia García-Salguero ◽  
José A. Lupiáñez ◽  
Eva E. Rufino-Palomares
Keyword(s):  
Antioxidant Enzyme ◽  
Cell Lines ◽  
Enzyme Activities ◽  
Biological Properties ◽  
Control Group ◽  
Antioxidant Enzyme Activities ◽  
Glutathione S Transferase ◽  
Maslinic Acid ◽  
B16f10 Cells ◽  
Melanoma B16f10

Maslinic acid (MA) is a natural triterpene from Olea europaea L. with multiple biological properties. The aim of the present study was to examine MA’s effect on cell viability (by the MTT assay), reactive oxygen species (ROS levels, by flow cytometry) and key antioxidant enzyme activities (by spectrophotometry) in murine skin melanoma (B16F10) cells compared to those on healthy cells (A10). MA induced cytotoxic effects in cancer cells (IC50 42 µM), whereas no effect was found in A10 cells treated with MA (up to 210 µM). In order to produce a stress situation in cells, 0.15 mM H2O2 was added. Under stressful conditions, MA protected both cell lines against oxidative damage, decreasing intracellular ROS, which were higher in B16F10 than in A10 cells. The treatment with H2O2 and without MA produced different responses in antioxidant enzyme activities depending on the cell line. In A10 cells, all the enzymes were up-regulated, but in B16F10 cells, only superoxide dismutase, glutathione S-transferase and glutathione peroxidase increased their activities. MA restored the enzyme activities to levels similar to those in the control group in both cell lines, highlighting that in A10 cells, the highest MA doses induced values lower than control. Overall, these findings demonstrate the great antioxidant capacity of MA.

Effect of downregulation of ZEB1 on vimentin expression, tumour migration and tumourigenicity of melanoma B16F10 cells and CSCs

2014 ◽  
Vol 38 (4) ◽  
pp. 452-461 ◽  
Author(s):  
Jun Dou ◽  
Xiangfeng He ◽  
Yurong Liu ◽  
Yaqian Wang ◽  
Fengshu Zhao ◽  
...  
Keyword(s):  
Vimentin Expression ◽  
B16f10 Cells ◽  
Melanoma B16f10
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