A cross-linking graphene oxide–polyethyleneimine hybrid film containing ciprofloxacin: one-step preparation, controlled drug release and antibacterial performance

2015 ◽  
Vol 3 (8) ◽  
pp. 1605-1611 ◽  
Author(s):  
Tiefan Huang ◽  
Lin Zhang ◽  
Huanlin Chen ◽  
Congjie Gao
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Release ◽  
Hybrid Film ◽  
Controlled Drug Release ◽  
Cross Linking ◽  
Antibacterial Performance ◽  
One Step ◽  
Novel Drug Delivery System ◽  
Novel Drug

A graphene oxide film was cross-linked by polyethyleneimine as a novel drug delivery system which showed excellent antibacterial performance.

Chitosan-based magnetic/fluorescent nanocomposites for cell labelling and controlled drug release

2017 ◽  
Vol 41 (4) ◽  
pp. 1736-1743 ◽  
Author(s):  
Yongling Ding ◽  
Hong Yin ◽  
Shirley Shen ◽  
Kangning Sun ◽  
Futian Liu
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Cell Labelling ◽  
Chitosan Matrix ◽  
Novel Drug Delivery System ◽  
Novel Drug

A novel drug delivery system, containing functional Fe3O4, CdTe@ZnS QDs, doxorubicin and a chitosan matrix, was designed via a polymer crosslinking method.

Bacterial cellulose/graphene oxide nanocomposite as a novel drug delivery system

2017 ◽  
Vol 17 (2) ◽  
pp. 249-254 ◽  
Author(s):  
Honglin Luo ◽  
Haiyong Ao ◽  
Gen Li ◽  
Wei Li ◽  
Guangyao Xiong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Bacterial Cellulose ◽  
Drug Delivery System ◽  
Delivery System ◽  
Novel Drug Delivery System ◽  
Novel Drug

scholarly journals Hybrid mesoporous silica with controlled drug release

2019 ◽  
Vol 84 (9) ◽  
pp. 1027-1039 ◽  
Author(s):  
László Almásy ◽  
Ana-Maria Putz ◽  
Qiang Tian ◽  
Gennady Kopitsa ◽  
Tamara Khamova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
Sol Gel ◽  
Nitrogen Adsorption ◽  
Controlled Drug Release ◽  
Ammonium Bromide ◽  
Structure Directing Agent ◽  
One Step

The mesoporous silica particles were prepared by the sol?gel method in one-step synthesis, in acidic conditions, from tetraethoxysilane (TEOS) and methyltriethoxysilane (MTES), varying the mole ratio of the silica precursors. Nitric acid was used as catalyst at room temperature and hexadecyltrimethyl ammonium bromide (CTAB) as structure directing agent. Optical properties, porosity and microstructure of the materials in function of the MTES/TEOS ratio were evaluated using infrared spectroscopy, nitrogen adsorption and small angle X-ray scattering. All materials showed the ordered pore structure and the high specific surfaces, making them suitable as the drug delivery systems. Drug loading and release tests using ketoprofen were performed to assess their performance for drug delivery applications. The amount of the methylated precursor used in the synthesis had little effect on the drug loading capacity, but had a strong influence on the initial rate of the drug release.

scholarly journals First step towards a model system of the drug delivery network based on amide-POSS nanocarriers

RSC Advances ◽  
2017 ◽  
Vol 7 (14) ◽  
pp. 8394-8401 ◽  
Author(s):  
Łukasz John ◽  
Mariola Malik ◽  
Mateusz Janeta ◽  
Sławomir Szafert
Keyword(s):  
Drug Delivery ◽  
Carboxylic Acid ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Model System ◽  
Novel Drug Delivery System ◽  
Novel Drug ◽  
Delivery Network ◽  
Acid Salts

We present the synthetic and release aspects of a novel drug delivery system (DDS) based on amido-functionalized POSS. DDS after drug release hydrolyses at pH = 7.40 to non-toxic products such as carboxylic acid salts and aminopropyl-POSS.

scholarly journals Simultaneous monitoring of the drug release and antitumor effect of a novel drug delivery system-MWCNTs/DOX/TC

Drug Delivery ◽  
2017 ◽  
Vol 24 (1) ◽  
pp. 143-151 ◽  
Author(s):  
Xia Dong ◽  
Zhiting Sun ◽  
Xiaoxiao Wang ◽  
Dunwan Zhu ◽  
Lanxia Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Antitumor Effect ◽  
Novel Drug Delivery System ◽  
Novel Drug

scholarly journals Intra Nasal In situ Gelling System of Lamotrigine Using Ion Activated Mucoadhesive Polymer

2017 ◽  
Vol 11 (1) ◽  
pp. 222-244 ◽  
Author(s):  
Asha Paul ◽  
K.M .Fathima ◽  
Sreeja C. Nair
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Evaluation Studies ◽  
Nasal Administration ◽  
Permeation Studies ◽  
Novel Drug Delivery System ◽  
Histopathological Studies ◽  
Novel Drug

Background:A novel drug delivery system for treating acute epileptic condition.Objective:To develop an intranasal mucoadhesive formulation of Lamotrigine (LTG) loadedinsitugel, for the treatment of epilepsy to avoid possible side effects and first pass metabolism associated with conventional treatment.Methods:Lamotrigine was loaded into different polymeric solutions of gellan and xanthan gum.Results:All formulations subjected to various evaluation studies were within their acceptable limits. The pH of formulation ranges between 5.8 ±.001 to 6.8 ±.005 indicating that no mucosal irritation is expected as pH was in acceptable range.Invitrodrug release from the mucoadhesiveinsitugel formulations showed immediate drug release pattern with a maximum drug release of 97.02 ±0.54% for optimized G5 formulation within 20min.Exvivopermeation studies of optimized formulation G5 and control formulation was estimated.Exvivopermeation studies of G5insituformulation done for a period of 12 h resulted in slow, sustained release and greater permeability significance(P <0.05) through nasal mucosa when compared to control. Histopathological studies showed that G5 formulation was safer for nasal administration without any irritation. The stability studies indicated that gels were stable over 45 days in refrigerated condition (4±2ºC).Conclusion:The intranasalinsitugelling system is a promising novel drug delivery system for an antiepileptic drug lamotrigine which could enhance nasal residence time with increased viscosity and mucoadhesive character and provided better release profile of drug for treating acute epileptic conditions.

Sign in / Sign up

Export Citation Format

Share Document