Manganism and Parkinson's disease: Mn(ii) and Zn(ii) interaction with a 30-amino acid fragment

A 30-amino acid fragment, Ac-SPDEKHELMIQLQKLDYTVGFCGDGANDCG-Am, from residues 1164 to 1193 in the encoded protein from Parkinson's disease gene Park9 (YPk9), was studied for manganese and zinc binding.

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Review of computational approaches to Parkinson’s disease gene prediction

2020 3rd International Conference on Intelligent Sustainable Systems (ICISS) ◽

10.1109/iciss49785.2020.9315926 ◽

2020 ◽

Author(s):

RHEA MARY JOSI ◽

R. I. MINU

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Disease Gene ◽

Gene Prediction ◽

Computational Approaches ◽

Disease Gene Prediction

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Neuropeptides, excitatory amino acid and adenosine A2 receptors regulate D2 receptors via intramembrane receptor-receptor interactions. Relevance for Parkinson's disease and schizophrenia

Neurochemistry International ◽

10.1016/0197-0186(92)90242-j ◽

1992 ◽

Vol 20 ◽

pp. 215-224 ◽

Cited By ~ 19

Author(s):

K. Fuxe ◽

L.F. Agnati ◽

G. von Euler ◽

S. Tanganelli ◽

W.T O'Connor ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Amino Acid ◽

Excitatory Amino Acid ◽

D2 Receptors ◽

Receptor Interactions ◽

A2 Receptors

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Methods for Increasing the Expression Level of a Soluble Fusion Protein Encoding a 62 Amino Acid Fragment of the α-Subunit of the Nicotinic Acetylcholine Receptora

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1995.tb17468.x ◽

1995 ◽

Vol 757 (1) ◽

pp. 117-119

Author(s):

LISA N. GENTILE ◽

EDWARD HAWROT

Keyword(s):

Amino Acid ◽

Fusion Protein ◽

Expression Level ◽

Nicotinic Acetylcholine ◽

Α Subunit ◽

Amino Acid Fragment ◽

Acid Fragment ◽

Protein Encoding ◽

Soluble Fusion Protein

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A Drosophila nuclear localisation signal included in an 18 amino acid fragment from the serendipity δ zinc finger protein

FEBS Letters ◽

10.1016/0014-5793(91)80229-v ◽

1991 ◽

Vol 280 (1) ◽

pp. 167-170 ◽

Cited By ~ 3

Author(s):

Stéphane Noselli ◽

Alain Vincent

Keyword(s):

Amino Acid ◽

Zinc Finger ◽

Zinc Finger Protein ◽

Nuclear Localisation Signal ◽

Nuclear Localisation ◽

Amino Acid Fragment ◽

Finger Protein ◽

Acid Fragment

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Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/3807476 ◽

2020 ◽

Vol 2020 ◽

pp. 1-14

Author(s):

Ting Sun ◽

Zhe-Xu Ding ◽

Xin Luo ◽

Qing-Shan Liu ◽

Yong Cheng

Keyword(s):

Oxidative Stress ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Amino Acid ◽

Dopaminergic Neurons ◽

Motor Coordination ◽

Oxidized Lipids ◽

Metabolomic Analysis ◽

Neuroprotective Effects ◽

And Control

Parkinson’s disease (PD) is a common and complex neurodegenerative disease; the pathogenesis of which is still uncertain. Exosomes, nanosized extracellular vesicles, have been suggested to participate in the pathogenesis of PD, but their role is unknown. Here, a metabolomic analysis of serum and brain exosomes showed differentially expressed metabolites between 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride- (MPTP-) induced PD mice and control mice, such as oxidized lipids, vitamins, and cholesterol. These metabolites were enriched in coenzyme, nicotinamide, and amino acid pathways related to PD, and they could be served as preclinical biomarkers. We further found that blood-derived exosomes from healthy volunteers alleviated impaired motor coordination in MPTP-treated mice. Results from immunohistochemistry and western blotting indicated that the loss of dopaminergic neurons in substantia nigra and striatum of PD model mice was rescued by the exosome treatment. The exosome treatment also restored the homeostasis of oxidative stress, neuroinflammation, and cell apoptosis in the model mice. These results suggest that exosomes are important mediators for PD pathogenesis, and exosomes are promising targets for the diagnosis and treatment of PD.

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