scholarly journals Improved antiviral activity of a polyamide against high-risk human papillomavirus via N-terminal guanidinium substitution

MedChemComm ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 2076-2082 ◽  
Author(s):  
C. H. Castaneda ◽  
M. J. Scuderi ◽  
T. G. Edwards ◽  
G. D. Harris Jr. ◽  
C. M. Dupureur ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Antiviral Activity

We report the synthesis of two novel pyrrole–imidazole polyamides with N-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing HPV strains.

scholarly journals Molecular characterization of high-risk human papillomavirus (HR-HPV) in women in Lomé, Togo

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Akouélé P. Kuassi-Kpede ◽  
Essolakina Dolou ◽  
Théodora M. Zohoncon ◽  
Ina Marie Angèle Traore ◽  
Gnatoulma Katawa ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
West Africa ◽  
Public Health Problem ◽  
Hpv Infection ◽  
Cervical Lesions ◽  
Hpv Genotypes ◽  
Precancerous Cervical Lesions ◽  
High Risk Hpv ◽  
First Time

Abstract Background The causative agent of cervical cancer referred to as Human papillomavirus (HPV) remains a real public health problem. Many countries in West Africa, such as Togo have no data on the high-risk HPV (HR-HPV) infection and genotypes distribution. In order to fill the knowledge gap in the field in Togo, the main objective of this study was to determine the prevalence of pre-cancerous lesions of the cervix and HR-HPV genotypes among Togolese women. Methods Samples were collected from 240 women by introducing a swab in the cervix. Then, the screening of precancerous cervical lesions using the visual inspection with acetic acid and lugol (VIA / VIL) was conducted. The HR-HPV genotypes were characterised by real-time multiplex PCR. Results Out of 240 women recruited, 128 (53.3%) were infected by HR-HPV. The most common genotypes were HPV 56 (22.7%), followed by HPV 51 (20.3%), HPV 31 (19.5%), HPV 52 (18.8%) and HPV 35 (17.2%). The least common genotypes were HPV 33 (2.3%) and HPV 16 (2.3%). Among the women, 1.3% (3/240) were positive to VIA/VIL. Conclusion This study allowed HR-HPV genotypes to be characterised for the first time in Lomé, Togo. This will help in mapping the HR-HPV genotypes in West Africa.

Prevalence of oropharyngeal high-risk human papillomavirus in tumor-free tonsil tissue in adults

2021 ◽  
pp. 103063
Author(s):  
Erdem Mengi ◽  
Cüneyt Orhan Kara ◽  
Yeliz Arman Karakaya ◽  
Ferda Bir
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Tonsil Tissue

scholarly journals Development of Antiviral CVC (Chief Value Cotton) Fabric

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2601
Author(s):  
Wen-Yi Wang ◽  
Sui-Lung Yim ◽  
Chun-Ho Wong ◽  
Chi-Wai Kan
Keyword(s):  
High Risk ◽  
Antiviral Activity ◽  
Cotton Fabric ◽  
Protective Clothing ◽  
Feline Coronavirus

The outbreak of COVID-19 has already generated a huge societal, economic and political losses worldwide. The present study aims to investigate the antiviral activity of Poly(hexamethylene biguanide) hydrochloride (PHMB) treated fabric against COVID-19 by using the surrogate Feline coronavirus. The antiviral analysis indicated that up to 94% of coronavirus was killed after contacting the CVC fabric treated with PHMB for 2 h, which suggests that PHMB treated fabric could be used for developing protective clothing and beddings with antiviral activity against coronavirus and can play a role in fighting the transmission of COVID-19 in the high-risk places.

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