scholarly journals Development of Antiviral CVC (Chief Value Cotton) Fabric

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2601
Author(s):  
Wen-Yi Wang ◽  
Sui-Lung Yim ◽  
Chun-Ho Wong ◽  
Chi-Wai Kan
Keyword(s):  
High Risk ◽  
Antiviral Activity ◽  
Cotton Fabric ◽  
Protective Clothing ◽  
Feline Coronavirus

The outbreak of COVID-19 has already generated a huge societal, economic and political losses worldwide. The present study aims to investigate the antiviral activity of Poly(hexamethylene biguanide) hydrochloride (PHMB) treated fabric against COVID-19 by using the surrogate Feline coronavirus. The antiviral analysis indicated that up to 94% of coronavirus was killed after contacting the CVC fabric treated with PHMB for 2 h, which suggests that PHMB treated fabric could be used for developing protective clothing and beddings with antiviral activity against coronavirus and can play a role in fighting the transmission of COVID-19 in the high-risk places.

Melanomas in Children

1995 ◽  
Vol 16 (10) ◽  
pp. 365-369
Author(s):  
Seth J. Orlow
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Protective Clothing ◽  
Pathologic Examination ◽  
Solar Exposure ◽  
Parents And Children ◽  
Grassroots Level ◽  
Suspicious Lesions

Although rare, melanomas do occur in children and adolescents. Pediatricians should be aware of the clinical features of melanoma and the risk factors for developing this malignancy. Children at high risk for melanoma should have at least annual cutaneous examinations in search of suspicious lesions. If a lesion is suspected of being a melanoma, it should be removed surgically and submitted for pathologic examination. Education of parents and children about the deleterious effects of ultraviolet light affords a means of counteracting the increasing incidence of melanoma at the grassroots level. The use of sunscreens, hats, and other protective clothing and the judicious timing of daily solar exposure should serve to prevent sunburning, limit tanning, and decrease the incidence of melanoma and other more common cutaneous malignancies, such as basal cell carcinoma and squamous cell carcinoma.

scholarly journals Improved antiviral activity of a polyamide against high-risk human papillomavirus via N-terminal guanidinium substitution

MedChemComm ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 2076-2082 ◽  
Author(s):  
C. H. Castaneda ◽  
M. J. Scuderi ◽  
T. G. Edwards ◽  
G. D. Harris Jr. ◽  
C. M. Dupureur ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Antiviral Activity

We report the synthesis of two novel pyrrole–imidazole polyamides with N-terminal guanidinium or tetramethylguanidinium groups and evaluate their antiviral activity against three cancer-causing HPV strains.

scholarly journals Antiviral activity of itraconazole against type I feline coronavirus infection

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Tomomi Takano ◽  
Misuzu Akiyama ◽  
Tomoyoshi Doki ◽  
Tsutomu Hohdatsu
Keyword(s):  
Antiviral Activity ◽  
Type I ◽  
Coronavirus Infection ◽  
Feline Coronavirus

scholarly journals Detoxification Properties of Guanidinylated Chitosan Against Chemical Warfare Agents and Its Application to Military Protective Clothing

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1461 ◽  
Author(s):  
Woong Kwon ◽  
Euigyung Jeong
Keyword(s):  
Acetic Acid ◽  
Cotton Fabric ◽  
Protective Clothing ◽  
Water Solution ◽  
Chemical Warfare Agents ◽  
Treatment Method ◽  
Chemical Warfare Agent ◽  
Chemical Warfare ◽  
Warfare Agents ◽  
First Time

This study investigates the detoxification properties of guanidinylated chitosan against chemical warfare agents and its application to the preparation of military protective clothing. Guanidinylated chitosan was synthesized by chitosan guanidinylation with cyanamide. The detoxification properties of the guanidinylated chitosan were then evaluated using a chemical warfare agent simulant, called diisopropylfluorophosphate (DFP). Cotton fabric was treated with 1 wt.% of guanidinylated chitosan in acetic acid and water solution using the simple and conventional textile treatment method of pad–dry–cure. The detoxification properties of the guanidinylated chitosan-treated cotton fabric were evaluated to investigate the application of guanidinylated chitosan to the preparation of military protective clothing. Subsequently, 71.3% of DFP was hydrolyzed to non-hazardous diisopropylhydrogenphosphate (DHP) in 2 h because of the base organocatalytic activity of 0.02 g guanidinylated chitosan itself. Moreover, 60.1% of DFP was hydrolyzed by the catalytic activity of the guanidinylated chitosan-treated cotton fabric, which contained only 0.0002 g of guanidinylated chitosan. This result shows that the guanidinylated chitosan itself has detoxification properties for hydrolyzing DFP to DHP, and its detoxification properties can be more efficient when applied to cotton fabric because it showed 84.3% of the detoxification properties with only 1 wt.% of guanidinylated chitosan. For the first time, this study shows that guanidinylated chitosan has considerable detoxification properties and can be used as an agent to prepare protective clothing.

scholarly journals Superamphiphobic and Flame-Resistant Cotton Fabrics for Protective Clothing

2021 ◽  
Author(s):  
Xiang Liu ◽  
Qingqing Shao ◽  
Jiqiang Cao ◽  
Zhaoqun Du ◽  
Weidong Yu
Keyword(s):  
Contact Angle ◽  
Flame Retardant ◽  
Cotton Fabric ◽  
Flame Retardancy ◽  
Protective Clothing ◽  
Mechanical Damage ◽  
Dip Coating ◽  
Water Contact ◽  
Protective Properties ◽  
Potential Applications

Abstract Superamphiphobic and flame-retardant finishing of cotton fabric can significantly improve its protective properties to expand its applications, such as protective clothing. However, creating such materials is still a challenging issue. Herein, we present a facile strategy to fabricate superamphiphobic and flame-retardant cotton fabric (SFC) via step-by-step dip-coating and spraying technology. Ammonium polyphosphate (APP) endows cotton fabric excellent flame retardancy. The robust coating formed by the polymerization product of ethyl 2-cyanoacrylate (ECA) and 1 H ,1 H ,2 H ,2 H - perfluorooctyl trichlorosilane (FOCS) can not only protect APP from being damaged, but also trap air to form "air plastron", which makes SFC have excellent antifouling, chemical repellence and self-cleaning. The resulting SFC exhibited superamphiphobicity and flame retardancy with water contact angle of 161°, oil contact angle of 158° and LOI of 30%. After UV irradiation, mechanical damage, 180° oven heating and ultrasonic washing, it still maintains excellent hydrophobicity without loss of flame retardancy. This study expands the potential applications of cotton and provides feasible technologies for improving the overall efficiency of cotton.

Preparation and characterisation of fire-resistant PNIPAAm/SA/AgNP thermosensitive network hydrogels and laminated cotton fabric used in firefighter protective clothing

Cellulose ◽  
2020 ◽  
Vol 27 (9) ◽  
pp. 5391-5406 ◽  
Author(s):  
Zhicai Yu ◽  
Abhijeet Suryawanshi ◽  
Hualing He ◽  
Jinru Liu ◽  
Yongquan Li ◽  
...  
Keyword(s):  
Cotton Fabric ◽  
Protective Clothing ◽  
Firefighter Protective Clothing

scholarly journals Possible Antiviral Activity of 5-Aminolevulinic Acid in Feline Infectious Peritonitis Virus (Feline Coronavirus) Infection

2021 ◽  
Vol 8 ◽  
Author(s):  
Tomomi Takano ◽  
Kumi Satoh ◽  
Tomoyoshi Doki
Keyword(s):  
Antiviral Activity ◽  
Aminolevulinic Acid ◽  
Low Molecular Weight ◽  
Animal Cells ◽  
Feline Infectious Peritonitis ◽  
Treatment And Prevention ◽  
Amino Levulinic Acid ◽  
Life Threatening ◽  
Coronavirus Infection ◽  
Feline Coronavirus

Feline infectious peritonitis (FIP) is a life-threatening infectious disease of cats caused by virulent feline coronavirus (FIP virus: FIPV). For the treatment of FIP, several effective antivirals were recently reported, but many of these are not available for practical use. 5-amino levulinic acid (5-ALA) is a low-molecular-weight amino acid synthesized in plant and animal cells. 5-ALA can be synthesized in a large amount, and it is widely applied in the medical and agricultural fields. We hypothesized that 5-ALA inhibits FIPV infection. Therefore, we evaluated its antiviral activity against FIPV in felis catus whole fetus-4 cells and feline primary macrophages. FIPV infection was significantly inhibited by 250 μM 5-ALA. Our study suggested that 5-ALA is applicable for the treatment and prevention of FIPV infection.

Comprehensive treatment of cervical intraepithelial neoplasia

GYNECOLOGY ◽  
2021 ◽  
Vol 23 (1) ◽  
pp. 62-67
Author(s):  
Liana S. Mkrtchian ◽  
Liudmila Iu. Grivtsova ◽  
Valentina I. Kiseleva ◽  
Anna M. Aleshina ◽  
Liudmila I. Krikunova
Keyword(s):  
High Risk ◽  
Antiviral Activity ◽  
Antiviral Drug ◽  
Intraepithelial Neoplasia ◽  
Lymphocyte Subpopulations ◽  
Comprehensive Treatment ◽  
Group 3 ◽  
Group 2 ◽  
High Risk Hpv ◽  
Group 1

Aim. To study the effectiveness of the use of Neovir (sodium oxodihydroacridinyl acetates) as immunomodulatory and antiviral drug in the comprehensive treatment of various grade cervical intraepithelial neoplasia (CIN). Study design: prospective comparative study. Materials and methods. The study included 60 patients (mean age 34.78.2 years) with morphologically verified various grade CIN, who were received comprehensive treatment, including the use of Neovir (sodium oxodihydroacridinyl acetate) as the drug with immunomodulatory and antiviral activity, 250 mg/2 ml intramuscularly every 48 hours, 10 injections before (group 1) or after (group 2) multi-stage radiosurgical diagnostic and treatment procedure or only a similar surgical intervention (group 3). All patients underwent complete clinical, morphological and laboratory examination with monitoring for the presence of high-risk human papillomavirus (HPV) in the cervical scraping and the dynamics of peripheral blood lymphocyte subpopulations. Results. Dynamic follow-up showed that in a month after surgery, patients who were treated with radiosurgical resection as monotherapy (group 3) had the lowest rate of complete epithelialization of the cervical stump 30.0% vs 55.0 and 65,0% in the group 1 and group 2 respectively. In this group, the proportion of patients with persistent viral infection was 1.52 times higher than in the groups where an antiviral drug was used in combination with radiosurgical intervention 35.7% vs 17.6 and 22.2% in the group 1 and group2, respectively. In 6 months, elimination of high-risk HPV in groups with comprehensive treatment reached 94.5 in the group 1 and 94.1% in the group 2 (p0.05) vs 78.6% in the group 3. The lowest number of TNK- and NK-cells was found in the group of patients who received radiosurgical treatment as monotherapy, which correlated with the highest incidence of high-risk HPV persistence after treatment in this group. Conclusions. In patients with various grade CIN, the use of an immunomodulatory drug with antiviral activity in combination with radiosurgical intervention promotes early epithelialization of the cervix and elimination of high-risk HPV, which is confirmed by significant changes in the lymphocyte subpopulations which provide antiviral immunity.

scholarly journals Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Che-Ming Jack Hu ◽  
Wei-Shan Chang ◽  
Zih-Syun Fang ◽  
You-Ting Chen ◽  
Wen-Lin Wang ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Vacuolar Atpase ◽  
Feline Coronavirus
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