An amphipathic lytic peptide for enhanced and selective delivery of ellipticine

2016 ◽  
Vol 4 (24) ◽  
pp. 4348-4355 ◽  
Author(s):  
Sheng Lu ◽  
Yong Ding ◽  
Yan Wu ◽  
Rong Wang ◽  
Ran Pan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bacterial Infection ◽  
Membrane Disruption ◽  
Lytic Peptide ◽  
Selective Membrane ◽  
Selective Delivery ◽  
Lytic Peptides

Cationic lytic peptides (CLPs) have shown promise in treating bacterial infection and cancer via selective membrane disruption but are seldom studied for drug delivery potential.

scholarly journals Selective Membrane Disruption Mechanism of an Antibacterial γ -AApeptide Defined by EPR Spectroscopy

2016 ◽  
Vol 110 (8) ◽  
pp. 1789-1799 ◽  
Author(s):  
Pavanjeet Kaur ◽  
Yaqiong Li ◽  
Jianfeng Cai ◽  
Likai Song
Keyword(s):  
Epr Spectroscopy ◽  
Membrane Disruption ◽  
Selective Membrane

scholarly journals Halloysite clay nanotubes as effective nanocarriers for the adsorption and loading of vancomycin for sustained release

RSC Advances ◽  
2017 ◽  
Vol 7 (34) ◽  
pp. 21352-21359 ◽  
Author(s):  
Qingqing Pan ◽  
Neng Li ◽  
Yu Hong ◽  
Heng Tang ◽  
Zongfu Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Bacterial Infection ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Infection Treatment ◽  
Local Drug Delivery System ◽  
Clay Nanotubes

A simple and effective local drug delivery system with halloysite clay nanotubes as nanocarriers for vancomycin was prepared for the bacterial infection treatment.

scholarly journals Passive and catalytic antibodies and drug delivery

2004 ◽  
Vol 76 (5) ◽  
pp. 983-989 ◽  
Author(s):  
G. Michael Blackburn ◽  
J. H. Rickard ◽  
S. Cesaro-Tadic ◽  
D. Lagos ◽  
A. Mekhalfia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Specific Antibody ◽  
Catalytic Antibodies ◽  
The Other ◽  
Covalent Attachment ◽  
Enzyme Prodrug Therapy ◽  
Toxic Agents ◽  
Antibody Conjugate ◽  
Selective Delivery ◽  
The One

Antibodies are one of the most promising components of the biotechnology repertoire for the purpose of drug delivery. On the one hand, they are proven agents for cell-selective delivery of highly toxic agents in a small but expanding number of cases. This technology calls for the covalent attachment of the cytotoxin to a tumor-specific antibody by a linkage that is reversible under appropriate conditions (antibody conjugate therapy, ACT —“passive delivery”). On the other hand, the linker cleavage can be accomplished by a protein catalyst attached to the tumor-specific antibody (“catalytic delivery”). Where the catalyst is an enzyme, this approach is known as antibody-directed enzyme prodrug therapy (ADEPT). Where the transformation is brought about by a catalytic antibody, it has been termed antibody-directed abzyme prodrug therapy (ADAPT). These approaches will be illustrated with emphasis on how their demand for new biotechnology is being realized by structure-based protein engineering.

scholarly journals Soft iontronic delivery devices based on an intrinsically stretchable ion selective membrane

2021 ◽  
Author(s):  
Dennis Cherian ◽  
Samuel Lienemann ◽  
Tobias Abrahamsson ◽  
Nara Kim ◽  
Magnus Berggren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Controlled Drug Delivery ◽  
Controlled Delivery ◽  
Ion Exchange Membranes ◽  
Delivery Device ◽  
Energy Devices ◽  
Skin Patch ◽  
Selective Membrane ◽  
Drug Delivery Devices

Abstract Implantable electronically controlled drug delivery devices can provide precision theraputic treatments by highly spatiotemporally controlled delivery. Iontronic delivery devices rely on the movement of ions rather than liquid, and can therefore achieve electronically controlled precision delivery in a compact setting without disturbing the microenvironment within the tissue with fluid flow. For maximum precision, the delivery device needs to be closely integrated into the tissue, which is challenging due to the mechanical mismatch between the soft tissue and the harder devices. Here we address this challenge by developing a soft and stretchable iontronic delivery device. By formulating an ink based on an in-house synthesized hyperbranched polyelectrolyte, water dispersed polyurethane, and a thickening agent, a viscous ink is developed for stencil patterning of soft ion exchange membranes. We use this ink for developing soft and stretchable delivery devices, which are characterized both in the relaxed and stretched state. We find that their functionality is preserved up to 100 % strain, with small variations in resistance due to the strain. Finally, we develop a skin patch to demonstrate the outstanding conformability of the developed device. The presented technology is attractive for future soft implantable delivery devices, and the stretchable ion exchange membranes may also find applications within wearable energy devices.

scholarly journals QbD-Based Development and Evaluation of Time-dependent Chronopharmaceutical Drug Delivery System of Amoxicillin Trihydrate for Management of Bacterial Infection

2018 ◽  
Vol 10 (03) ◽  
Author(s):  
Shyam Narayan Prasad ◽  
Ashok Kumar Sahoo ◽  
Abhijit V. Gothoskar
Keyword(s):  
Drug Delivery ◽  
Bacterial Infection ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bacterial Infections ◽  
Release Kinetics ◽  
Matrix Tablets ◽  
Critical Material ◽  
Amoxicillin Trihydrate

The present studies discuss about the quality by design (QbD)-based development and evaluation of chronomodulated release drug delivery system of amoxicillin trihydrate for management of bacterial infection. Initially, target product profile was defined and critical quality attributes were earmarked. Risk assessment study was performed for identifying the critical material attributes. Preformulation studies were carried out, and direct compression method was employed for the preparation of bilayer matrix tablets containing a delayed and a sustained release layer for preliminary optimization. Systematic formulation optimization was carried out using central composite design by selecting the concentration of Eudragit-L100 D55 and HPMCK4M. Mathematical modeling was performed and optimized compositions of the polymers were identified from the design space. Moreover, the prepared bilayer tablets were evaluated for various tablet properties including in vitro drug release study, release kinetics evaluation and characterized for FTIR, DSC, XRD, SEM studies, in vitro was-off test, antimicrobial assay and accelerated stability studies. In a nutshell, the present studies indicated the supremacy of designing a chronomodulated release bilayer tablet formulations of amoxicillin trihydrate for effective management of bacterial infections.

A Dense Magnetic Coil Array with Multi-locus and Multi-site Patterning

2021 ◽  
Author(s):  
Matthew Smith ◽  
Daniel Sievenpiper
Keyword(s):  
Drug Delivery ◽  
Membrane Disruption ◽  
Coil Array ◽  
Tumor Cell Membrane ◽  
Magnetic Coil ◽  
Magnetic Drug Delivery ◽  
Higher Power ◽  
Cell Membrane Disruption ◽  
Noninvasive Neuromodulation ◽  
Relevant Range

<p>· We propose multi-loci and multi-site current patterning (sequential or simultaneous) for precise, rapid and repeatable steering for improved neuronal targeting.</p><p>· Here we demonstrate these improvements by using a unique pixel cell for excitation synthesis as enabled by a three-layer dense magnetic coil array that is mapped to a hexagonal grid with cubic coordinates.</p><p>· We validate the theory with supporting simulations, experimental results and a scalable electronics design that can address a relevant range of larger coil diameters, higher power levels and topologies.</p><p><a></a></p><p>· Precise, rapid and repeatable patterns potentially offer new modalities for noninvasive neuromodulation (suprathreshold and subthreshold) and adjacent biomagnetic applications such as tumor cell membrane disruption [1], and magnetic drug delivery [2].</p>

A pH and hyaluronidase dual-responsive multilayer-based drug delivery system for resisting bacterial infection

2020 ◽  
Vol 527 ◽  
pp. 146806 ◽  
Author(s):  
Pirah Ayaz ◽  
Bingjie Xu ◽  
Xiansheng Zhang ◽  
Jiping Wang ◽  
Dan Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bacterial Infection ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dual Responsive
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