scholarly journals Novel T-C@AgNPs mediated biocidal mechanism against biofilm associated methicillin-resistant Staphylococcus aureus (Bap-MRSA) 090, cytotoxicity and its molecular docking studies

MedChemComm ◽  
2017 ◽  
Vol 8 (12) ◽  
pp. 2181-2194 ◽  
Author(s):  
H. M. Manukumar ◽  
B. Chandrasekhar ◽  
K. P. Rakesh ◽  
A. P. Ananda ◽  
M. Nandhini ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Molecular Docking ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Docking Studies ◽  
Methicillin Resistant ◽  
Molecular Docking Studies ◽  
Life Threatening

Staphylococcus aureus is a commonly found pathogen cause life threatening infections and can be controlled by nanoparticles as antibiofilm candidates.

scholarly journals Molecular Docking and Validation of Methicillin Resistant Staphylococcus aureus Targets against Geninthiocin

2021 ◽  
pp. 579-590
Author(s):  
G. S. Subha Lakshmi ◽  
A. Ronaldo Anuf ◽  
Samuel Gnana Prakash Vincent
Keyword(s):  
Staphylococcus Aureus ◽  
Molecular Docking ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Docking Studies ◽  
Protein Docking ◽  
Target Protein ◽  
Health Concern ◽  
Methicillin Resistant ◽  
Target Proteins ◽  
Life Threatening

Antibiotic resistance has been a serious public health concern in recent years. Methicillin resistant “Staphylococcus aureus” (MRSA) is a superbug that causes life threatening infections of Humanity which is difficult to treat. Geninthiocin is a macrocyclic thiopeptide with a 35-membered core moiety, which was isolated from marine streptomyces sp. ICN19, which has proven potent activity against MRSA.  Five target proteins PDB ID: 4YMX, 3ZDS, 3QLB, 4IEN and 1DXL were identified from MRSA for their presumptive action for Geninthiocin. In this study, we used molecular docking and molecular dynamic simulation, in order to validate Geninthiocin’s potential target protein.  Target proteins were subjected to ligand-protein docking studies. Based on their docking scores and Hydrogen bonding interactions, two possible proteins 4YMX and 3ZDS were further subjected to simulation strategies to validate the protein-drug interaction. Out of which, homogentisate1,2 dioxygenase turned out to be a possible drug target for Geninthiocin. The compound Geninthiocin could be developed as a potential inhibitor against the target protein homogentisate1,2-dioxygenase for exhibiting an effective antimicrobial activity.

Methicillin-Resistant Staphylococcus aureus: An Emerging Pathogen in Small Animals

2005 ◽  
Vol 41 (3) ◽  
pp. 150-157 ◽  
Author(s):  
J. Scott Weese
Keyword(s):  
Staphylococcus Aureus ◽  
Disease Surveillance ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Diagnostic Testing ◽  
Small Animals ◽  
Emerging Pathogen ◽  
Methicillin Resistant ◽  
Mild Disease ◽  
Life Threatening ◽  
The Impact

Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen in humans and is increasingly implicated in community-associated infections in people. In household pets, MRSA infections are uncommon but are on the rise, possibly because of the increased prevalence of human MRSA in the community. Clinical MRSA infections in some animals can be life threatening and difficult to treat; however, other animals may develop mild disease or only become colonized. Veterinarians should be aware of the concerns regarding MRSA and should develop an understanding of appropriate disease surveillance, diagnostic testing, and infection control in order to lessen the impact of MRSA on small animals.

scholarly journals Phenotypic and Genotypic Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Related to Persistent Endovascular Infection

Antibiotics ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 71 ◽  
Author(s):  
Liang Li ◽  
Michael R. Yeaman ◽  
Arnold S. Bayer ◽  
Yan Q. Xiong
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Specific Mechanism ◽  
Host Defense Peptides ◽  
Methicillin Resistant ◽  
Preventative Measures ◽  
Life Threatening ◽  
Genotypic Characteristics

Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (PB) represents an important subset of S. aureus infection and correlates with poor clinical outcomes. MRSA isolates from patients with PB differ significantly from those of resolving bacteremia (RB) with regard to several in vitro phenotypic and genotypic profiles. For instance, PB strains exhibit less susceptibility to cationic host defense peptides and vancomycin (VAN) killing under in vivo-like conditions, greater damage to endothelial cells, thicker biofilm formation, altered growth rates, early activation of many global virulence regulons (e.g., sigB, sarA, sae and agr) and higher expression of purine biosynthesis genes (e.g., purF) than RB strains. Importantly, PB strains are significantly more resistant to VAN treatment in experimental infective endocarditis as compared to RB strains, despite similar VAN minimum inhibitory concentrations (MICs) in vitro. Here, we review relevant phenotypic and genotypic characteristics related to the PB outcome. These and future insights may improve our understanding of the specific mechanism(s) contributing to the PB outcome, and aid in the development of novel therapeutic and preventative measures against this life-threatening infection.

Life-threatening infection due to community-acquired methicillin-resistant Staphylococcus aureus: case report and review

2009 ◽  
Vol 169 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Kalomoira Kefala-Agoropoulou ◽  
Efthimia Protonotariou ◽  
Danai Vitti ◽  
Sofia Sarafidou ◽  
Athanasia Anastasiou ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Case Report ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Life Threatening

Methicillin-resistant Staphylococcus aureus (MRSA) submandibular abscess in a neonate

2021 ◽  
Vol 14 (5) ◽  
pp. e242258
Author(s):  
Natalia Glibbery ◽  
Theodore Gouliouris ◽  
Jessica Bewick
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Complex Case ◽  
Airway Compromise ◽  
Methicillin Resistant ◽  
Life Threatening ◽  
Common Risk Factors ◽  
Male Neonate ◽  
Prompt Diagnosis

Neonatal suppurative submandibular sialadenitis and abscess formation is an exceedingly rare entity. This report describes a complex case of a male neonate with a methicillin-resistant Staphylococcus aureus (MRSA) submandibular abscess, requiring emergency intubation due to acute airway compromise. The patient was admitted to the paediatric intensive care unit, received appropriate antibiotic treatment and underwent urgent surgical drainage of the abscess. He made a full recovery and remains well 18 months later. No comorbidities or common risk factors for the disease were identified. Although extremely uncommon, neonatal submandibular abscesses can lead to significant morbidity. Neonates tend to present insidiously, and sudden clinical deterioration with airway compromise is possible. MRSA has been increasingly implicated in these infections, even in the absence of relevant risk factors. As such, continued clinical vigilance is essential for prompt diagnosis and prevention of life-threatening complications. Multidisciplinary input is paramount for appropriate management of these complex infections.

scholarly journals Blurred Molecular Epidemiological Lines Between the Two Dominant Methicillin-Resistant Staphylococcus aureus Clones

2019 ◽  
Vol 6 (9) ◽  
Author(s):  
Amy C Dupper ◽  
Mitchell J Sullivan ◽  
Kieran I Chacko ◽  
Aaron Mishkin ◽  
Brianne Ciferri ◽  
...  
Keyword(s):  
New York ◽  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Medical Center ◽  
Age Groups ◽  
Bloodstream Infections ◽  
Methicillin Resistant ◽  
Peripheral Intravenous Catheter ◽  
Life Threatening ◽  
Catheter Infections

Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) causes life-threatening infections in both community and hospital settings and is a leading cause of health care–associated infections (HAIs). We sought to describe the molecular epidemiological landscape of patients with MRSA bloodstream infections (BSIs) at an urban medical center by evaluating the clinical characteristics associated with the two dominant endemic clones. Methods Comprehensive clinical data from the electronic health records of 227 hospitalized patients ≥18 years old with MRSA BSI over a 33-month period in New York City were collected. The descriptive epidemiology and mortality associated with the two dominant clones were compared using logistic regression. Results Molecular analysis revealed that 91% of all single-patient MRSA BSIs were due to two equally represented genotypes, clonal complex (CC) 5 (n = 117) and CC8 (n = 110). MRSA BSIs were associated with a 90-day mortality rate of 27%. CC8 caused disease more frequently in younger age groups (56 ± 17 vs 67 ± 17 years old; P < .001) and in those of nonwhite race (odds ratio [OR], 3.45; 95% confidence interval [CI], 1.51–7.87; P = .003), with few other major distinguishing features. Morbidity and mortality also did not differ significantly between the two clones. CC8 caused BSIs more frequently in the setting of peripheral intravenous catheters (OR, 5.96; 95% CI, 1.51–23.50; P = .01). Conclusions The clinical features distinguishing dominant MRSA clones continue to converge. The association of CC8 with peripheral intravenous catheter infections underscores the importance of classical community clones causing hospital-onset infections. Ongoing monitoring and analysis of the dynamic epidemiology of this endemic pathogen are crucial to inform management and prevent disease.

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