scholarly journals One-pot synthesis of water-soluble near-infrared fluorescence RNase A capped CuInS2 quantum dots for in vivo imaging

RSC Advances ◽  
2017 ◽  
Vol 7 (80) ◽  
pp. 50949-50954 ◽  
Author(s):  
Yue Xi ◽  
Jianjun Yang ◽  
Yunshen Ge ◽  
Shenli Zhao ◽  
Jianguang Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Rnase A ◽  
Water Soluble ◽  
One Pot ◽  
Guided Surgery ◽  
Nir Fluorescence ◽  
Fluorescence Guided Surgery ◽  
Cuins2 Quantum Dots

Near-infrared (NIR) quantum dots (QDs) have been treated as a promising candidate of imaging agents for NIR fluorescence-guided surgery. Here, the RNase A-CuInS2 QDs is good candidate, which performers well in gastrointestinal system imaging.

scholarly journals Near-Infrared Molecular Imaging of Glioblastoma by Miltuximab®-IRDye800CW as a Potential Tool for Fluorescence-Guided Surgery

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 984 ◽  
Author(s):  
Dmitry M. Polikarpov ◽  
Douglas H. Campbell ◽  
Lucinda S. McRobb ◽  
Jiehua Wu ◽  
Maria E. Lund ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Near Infrared ◽  
Ex Vivo ◽  
Extent Of Resection ◽  
Fluorescent Imaging ◽  
Control Group ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Specific Accumulation

Glioblastoma (GBM) is one of the most aggressive tumors and its 5-year survival is approximately 5%. Fluorescence-guided surgery (FGS) improves the extent of resection and leads to better prognosis. Molecular near-infrared (NIR) imaging appears to outperform conventional FGS, however, novel molecular targets need to be identified in GBM. Proteoglycan glypican-1 (GPC-1) is believed to be such a target as it is highly expressed in GBM and is associated with poor prognosis. We hypothesize that an anti-GPC-1 antibody, Miltuximab®, conjugated with the NIR dye, IRDye800CW (IR800), can specifically accumulate in a GBM xenograft and provide high-contrast in vivo fluorescent imaging in rodents following systemic administration. Miltuximab® was conjugated with IR800 and intravenously administered to BALB/c nude mice bearing a subcutaneous U-87 GBM hind leg xenograft. Specific accumulation of Miltuximab®-IR800 in subcutaneous xenograft tumor was detected 24 h later using an in vivo fluorescence imager. The conjugate did not cause any adverse events in mice and caused strong fluorescence of the tumor with tumor-to-background ratio (TBR) reaching 10.1 ± 2.8. The average TBR over the 10-day period was 5.8 ± 0.6 in mice injected with Miltuximab®-IR800 versus 2.4 ± 0.1 for the control group injected with IgG-IR800 (p = 0.001). Ex vivo assessment of Miltuximab®-IR800 biodistribution confirmed its highly specific accumulation in the tumor. The results of this study confirm that Miltuximab®-IR800 holds promise for intraoperative fluorescence molecular imaging of GBM and warrants further studies.

Near-infrared Emitting Gold-silver Nanoclusters with Large Stokes Shift for Two-Photon in Vivo Imaging

2021 ◽  
Author(s):  
Yaowei Peng ◽  
Xiaoyu Huang ◽  
Fu Wang
Keyword(s):  
In Vivo Imaging ◽  
Near Infrared ◽  
Stokes Shift ◽  
Silver Nanoclusters ◽  
One Pot ◽  
Two Photon ◽  
Nir Fluorescence ◽  
Gold Silver ◽  
Stokes Shifts

Near-infrared emitting bi-metallic gold/silver nanoclusters with great stokes shifts were manufactured through one-pot synthesis. The gold/silver nanoclusters exhibit strong NIR fluorescence due to the silver effect, which can be applied...

scholarly journals Multimodal Mn-doped I–III–VI quantum dots for near infrared fluorescence and magnetic resonance imaging: from synthesis to in vivo application

Nanoscale ◽  
2014 ◽  
Vol 6 (15) ◽  
pp. 9264-9272 ◽  
Author(s):  
Gary Sitbon ◽  
Sophie Bouccara ◽  
Mariana Tasso ◽  
Aurélie Francois ◽  
Lina Bezdetnaya ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Quantum Dots ◽  
Magnetic Resonance ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Resonance Imaging ◽  
Near Infrared Fluorescence ◽  
Nir Fluorescence ◽  
Mn Doped

Cadmium-free quantum dots doped with Mn2+ions show promising results forin vivobimodal MRI and NIR fluorescence imaging.

Ultra-fast synthesis of water soluble MoO3−x quantum dots with controlled oxygen vacancies and their near infrared fluorescence sensing to detect H2O2

2020 ◽  
Vol 5 (11) ◽  
pp. 1538-1543
Author(s):  
Shichuan Zhong ◽  
Changchang Xing ◽  
An Cao ◽  
Tao Zhang ◽  
Xuejiao Li ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Detection Limit ◽  
Room Temperature ◽  
Oxygen Vacancies ◽  
Near Infrared ◽  
Fluorescence Probe ◽  
Water Soluble ◽  
Fluorescence Sensing ◽  
Nir Fluorescence ◽  
Fast Synthesis

We report a facile method for the synthesis of water soluble MoO3−x QDs with controlled oxygen vacancies at room temperature within 5 seconds, the QDs could be used as a NIR fluorescence probe to detect H2O2 with a low detection limit (3 nM).

scholarly journals Validation of a Three-Dimensional Head and Neck Spheroid Model to Evaluate Cameras for NIR Fluorescence-Guided Cancer Surgery

2021 ◽  
Vol 22 (4) ◽  
pp. 1966
Author(s):  
Claire Egloff-Juras ◽  
Ilya Yakavets ◽  
Victoria Scherrer ◽  
Aurélie Francois ◽  
Lina Bezdetnaya ◽  
...  
Keyword(s):  
Head And Neck ◽  
Near Infrared ◽  
Tumor Model ◽  
Resection Margins ◽  
Fluorescence Signal ◽  
Multicellular Tumor Spheroid ◽  
Guided Surgery ◽  
Nir Fluorescence ◽  
Fluorescence Guided Surgery

Near-infrared (NIR) fluorescence-guided surgery is an innovative technique for the real-time visualization of resection margins. The aim of this study was to develop a head and neck multicellular tumor spheroid model and to explore the possibilities offered by it for the evaluation of cameras for NIR fluorescence-guided surgery protocols. FaDu spheroids were incubated with indocyanine green (ICG) and then included in a tissue-like phantom. To assess the capability of Fluobeam® NIR camera to detect ICG in tissues, FaDu spheroids exposed to ICG were embedded in 2, 5 or 8 mm of tissue-like phantom. The fluorescence signal was significantly higher between 2, 5 and 8 mm of depth for spheroids treated with more than 5 µg/mL ICG (p < 0.05). The fluorescence intensity positively correlated with the size of spheroids (p < 0.01), while the correlation with depth in the tissue-like phantom was strongly negative (p < 0.001). This multicellular spheroid model embedded in a tissue-like phantom seems to be a simple and reproducible in vitro tumor model, allowing a comparison of NIR cameras. The ideal configuration seems to be 450 μm FaDu spheroids incubated for 24 hours with 0.05 mg/ml of ICG, ensuring the best stability, toxicity, incorporation and signal intensity.

One-pot synthesis of near-infrared type II quantum dots and their in vivo applications

RSC Advances ◽  
2013 ◽  
Vol 3 (29) ◽  
pp. 11511 ◽  
Author(s):  
Wing-Cheung Law ◽  
Rui Hu ◽  
Chih-Kuang Chen ◽  
Gaixia Xu ◽  
Xiaomei Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Type Ii ◽  
One Pot ◽  
One Pot Synthesis

Water-soluble Ag2S quantum dots for near-infrared fluorescence imaging in vivo

Biomaterials ◽  
2012 ◽  
Vol 33 (20) ◽  
pp. 5130-5135 ◽  
Author(s):  
Peng Jiang ◽  
Chun-Nan Zhu ◽  
Zhi-Ling Zhang ◽  
Zhi-Quan Tian ◽  
Dai-Wen Pang
Keyword(s):  
Quantum Dots ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Water Soluble ◽  
Near Infrared Fluorescence ◽  
Ag2s Quantum Dots ◽  
Near Infrared Fluorescence Imaging

One-Step Synthesis of Ribonucleases A–Ag Nanocomposites as Fluorescent Nanodrugs for in vivo Delivery

NANO ◽  
2021 ◽  
Vol 16 (09) ◽  
Author(s):  
Yuan Luo ◽  
Yunfeng Chen ◽  
Xing Yang ◽  
Yueming Wang ◽  
Yunxia Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
Rnase A ◽  
Multifunctional Composites ◽  
Fluorescent Indicators ◽  
Nir Fluorescence ◽  
Therapeutic Function ◽  
One Step ◽  
Ag Ncs

Proteins and enzymes with potential therapeutic function have been widely used in drug delivery. Meanwhile, nanocrystals (NCs) have showed their advantage as in vivo fluorescent indicators. Combining of these two kinds of materials can result in multifunctional composites. Here, a one-step synthesis of protein–NCs nanocomposites with near infrared (NIR) fluorescence and efficient therapeutic function was developed. Ag NCs were formed using ribonucleases A (RNase A) enzyme as a stabilizer. Meanwhile, the RNase A with long chain rapped around Ag NCs and formed RNase A–Ag nanocomposites. The nanocomposites remained both the NIR fluorescence of Ag NCs and antitumor activity of RNase A. The inhibition of the growth of tumor cells by the nanocomposites was confirmed. This study developed an efficient drug delivery system through combination of the protein and nanoparticles, which had potential clinical application in the future.

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