scholarly journals A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine

2018 ◽  
Vol 10 (25) ◽  
pp. 3066-3073 ◽  
Author(s):  
D. Martens ◽  
P. Ramirez-Priego ◽  
M. S. Murib ◽  
A. A. Elamin ◽  
A. B. Gonzalez-Guerrero ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Lab On A Chip ◽  
Biomarker Detection ◽  
Biomarker Analysis

We present a low-cost integrated nanophotonic lab-on-a-chip platform suitable for point-of-care (POC) biomarker analysis.

scholarly journals Silicon Photonic Biosensors Using Label-Free Detection

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3519 ◽  
Author(s):  
Enxiao Luan ◽  
Hossam Shoman ◽  
Daniel Ratner ◽  
Karen Cheung ◽  
Lukas Chrostowski
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Lab On A Chip ◽  
Complementary Metal Oxide Semiconductor ◽  
Oxide Semiconductor ◽  
System Level ◽  
High Yield ◽  
Label Free ◽  
Label Free Detection ◽  
Microfabrication Technology

Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, and Bragg grating waveguide-based sensors. Their sensing mechanisms and sensor performances, as well as real biomarkers for label-free detection, are exhibited and compared. We also review the development of chip-level integration for lab-on-a-chip photonic sensing platforms, which consist of the optical sensing device, flow delivery system, optical input and readout equipment. At last, some advanced system-level complementary metal-oxide semiconductor (CMOS) chip packaging examples are presented, indicating the commercialization potential for the low cost, high yield, portable biosensing platform leveraging CMOS processes.

scholarly journals Silicon Photonic Biosensors Using Label-Free Detection

2018 ◽  
Author(s):  
Enxiao Luan ◽  
Hossam Shoman ◽  
Daniel M. Ratner ◽  
Karen C. Cheung ◽  
Lukas Chrostowski
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Lab On A Chip ◽  
System Level ◽  
High Yield ◽  
Label Free ◽  
Label Free Detection ◽  
Microfabrication Technology ◽  
Scale Integration ◽  
Silicon Based

Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, and Bragg grating waveguide-based sensors. Their sensing mechanisms and sensor performances, as well as real biomarkers for label-free detection, are exhibited and compared. We also review the development of chip-level integration for lab-on-a-chip photonic sensing platforms, which consist of the optical sensing device, flow delivery system, optical input and readout equipment. At last, some advanced system-level CMOS-chip packaging examples are presented, indicating the commercialization potential for the low cost, high yield, portable biosensing platform leveraging CMOS processes.

scholarly journals Silicon Photonic Biosensors Using Label-Free Detection

2018 ◽  
Author(s):  
Enxiao Luan ◽  
Hossam Shoman ◽  
Daniel M. Ratner ◽  
Karen C. Cheung ◽  
Lukas Chrostowski
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Lab On A Chip ◽  
System Level ◽  
High Yield ◽  
Label Free ◽  
Label Free Detection ◽  
Microfabrication Technology ◽  
Scale Integration ◽  
Silicon Based

Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, and Bragg grating waveguide-based sensors. Their sensing mechanisms and sensor performances, as well as real biomarkers for label-free detection, are exhibited and compared. We also review the development of chip-level integration for lab-on-a-chip photonic sensing platforms, which consist of the optical sensing device, flow delivery system, optical input and readout equipment. At last, some advanced system-level CMOS-chip packaging examples are presented, indicating the commercialization potential for the low cost, high yield, portable biosensing platform leveraging CMOS processes.

What is the future of lab-on-a-chip diagnostic devices? Assessing changes in experts’ expectations over time

foresight ◽  
2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Fabio Mota ◽  
Luiza Amara Maciel Braga ◽  
Bernardo Pereira Pereira Cabral ◽  
Carlos Gilbert Conte Filho
Keyword(s):  
Industrial Development ◽  
Point Of Care ◽  
Low Cost ◽  
Diagnostic Testing ◽  
Lab On A Chip ◽  
Human Diseases ◽  
Scientific Publications ◽  
Content Type ◽  
The Future ◽  
The Way

Purpose Lab on-a-chip (LOC) may lead to low-cost point-of-care devices for the diagnosis of human diseases, possibly making laboratories dispensable. However, as it is still an emerging technology, very little is known about its future impact on the diagnosis of human diseases, and on the laboratory industry. Hence, the purpose of this study is to foresee possible developments of this technology through a consultation with researchers in the field in two distinct time periods. Design/methodology/approach Based on Technology Foresight, this study addresses this gap by assessing the opinions of over five hundred LOC researchers and tracking changes in their views on the future of LOC diagnostic devices. These researchers participated in a two-wave global survey with an interval of two and a half years Findings Although second-wave (2020) respondents are less optimistic than those of the first wave (2017), the results of both surveys show that LOC diagnostic devices are expected to: move from proof-of-concept demonstrations to industrial development, becoming commercially feasible worldwide; integrate all laboratory processes, delivering cheaper, faster and more reliable diagnoses than laboratories; and provide low-cost point-of-care solutions, improving access to healthcare. Research limitations/implications Although it would be desirable to collect and explore the views of different sets of stakeholders, the method of generating lists of survey respondents shows a bias toward academic/scientific circles because the respondents are authors of scientific publications. These publications may as well be authored by stakeholders from other fields but it is reasonable to assume that most of them are researchers affiliated with universities and research and development organizations. Therefore, this study lacks in providing an image of the future based on a more diverse set of respondents. Social implications The results show that these devices are expected to radically change the diagnostic testing market and the way laboratories are organized, perhaps moving to a non-laboratory-based model. In conclusion, in the coming decades, these devices may promote substantial changes in the way human diseases are diagnosed. Originality/value Only a few studies have attempted to foresee the future of LOC devices, and most are based on literature reviews. Thus, this study goes beyond the existing research by providing a broad understanding of what the future will look like from the views of researchers who are contributing to the advancement of knowledge in the field. The researchers invited to take part in this study are authors of LOC-related scientific publications indexed in the Web of Science Core Collection.

scholarly journals Polymer microfluidic devices: an overview of fabrication methods

2017 ◽  
Vol 1 (1) ◽  
pp. 67-79 ◽  
Author(s):  
Raquel O. Rodrigues ◽  
Rui Lima ◽  
Helder T. Gomes ◽  
Adrián M. T. Silva
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Lab On A Chip ◽  
Microfluidic Devices ◽  
Point Of Care Testing ◽  
Standard Methods ◽  
Time Consumption ◽  
Advantages And Disadvantages ◽  
Fundamental Research ◽  
Microfabrication Techniques

The amount of applications associated with microfluidic devices is increasing since the introduction of Lab-on-a-chip devices in the 1990s, especially regarding biomedical and clinical fields. However, in order for this technology to leave the fundamental research and become a day-life technology (e.g., as point-of-care testing), it needs to be disposable and reasonably less expensive. Polymers, due to their several advantages, such as easier microfabrication and low-cost, fill these needs. Several methods are reported regarding microfabrication and, thus, the main aim of the present work is to provide an overview of the most relevant microfabrication techniques found in literature employing polymers, clarifying also the main advantages and disadvantages of each technique and especially considering their cost and time-consumption. Moreover, a future outlook of low-cost microfabrication techniques and standard methods is provided.

scholarly journals Modular and Self-Contained Microfluidic Analytical Platforms Enabled by Magnetorheological Elastomer Microactuators

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 604
Author(s):  
Yuxin Zhang ◽  
Tim Cole ◽  
Guolin Yun ◽  
Yuxing Li ◽  
Qianbin Zhao ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Microfluidic Device ◽  
Microfluidic Chip ◽  
Point Of Care ◽  
Low Cost ◽  
Lab On A Chip ◽  
Magnetorheological Elastomer ◽  
Require Time ◽  
External Connection ◽  
Analytical Platforms

Portability and low-cost analytic ability are desirable for point-of-care (POC) diagnostics; however, current POC testing platforms often require time-consuming multiple microfabrication steps and rely on bulky and costly equipment. This hinders the capability of microfluidics to prove its power outside of laboratories and narrows the range of applications. This paper details a self-contained microfluidic device, which does not require any external connection or tubing to deliver insert-and-use image-based analysis. Without any microfabrication, magnetorheological elastomer (MRE) microactuators including pumps, mixers and valves are integrated into one modular microfluidic chip based on novel manipulation principles. By inserting the chip into the driving and controlling platform, the system demonstrates sample preparation and sequential pumping processes. Furthermore, due to the straightforward fabrication process, chips can be rapidly reconfigured at a low cost, which validates the robustness and versatility of an MRE-enabled microfluidic platform as an option for developing an integrated lab-on-a-chip system.

scholarly journals Validation of a point-of-care rapid diagnostic test for hepatitis C for use in resource-limited settings

2019 ◽  
Vol 11 (4) ◽  
pp. 314-315
Author(s):  
James S Leathers ◽  
Maria Belen Pisano ◽  
Viviana Re ◽  
Gertine van Oord ◽  
Amir Sultan ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Rapid Diagnosis ◽  
Direct Acting Antivirals ◽  
Resource Limited Settings ◽  
Rapid Diagnosis Test ◽  
Resource Limited ◽  
Specificity And Sensitivity ◽  
Hcv Screening ◽  
Direct Acting

Abstract Background Treatment of HCV with direct-acting antivirals has enabled the discussion of HCV eradication worldwide. Envisioning this aim requires implementation of mass screening in resource-limited areas, usually constrained by testing costs. Methods We validated a low-cost, rapid diagnosis test (RDT) for HCV in three different continents in 141 individuals. Results The HCV RDT showed 100% specificity and sensitivity across different samples regardless of genotype or viral load (in samples with such information, 90%). Conclusions The HCV test validated in this study can allow for HCV screening in areas of need when properly used.

scholarly journals Rapid and Sensitive Detection of miRNA Based on AC Electrokinetic Capacitive Sensing for Point-of-Care Applications

Sensors ◽  
2021 ◽  
Vol 21 (12) ◽  
pp. 3985
Author(s):  
Nan Wan ◽  
Yu Jiang ◽  
Jiamei Huang ◽  
Rania Oueslati ◽  
Shigetoshi Eda ◽  
...  
Keyword(s):  
Limit Of Detection ◽  
Point Of Care ◽  
Low Cost ◽  
Clinical Diagnostics ◽  
Detection Methods ◽  
Capacitive Sensing ◽  
Application Potential ◽  
Mirna Detection ◽  
Mirna 25 ◽  
Low Sensitivity

A sensitive and efficient method for microRNAs (miRNAs) detection is strongly desired by clinicians and, in recent years, the search for such a method has drawn much attention. There has been significant interest in using miRNA as biomarkers for multiple diseases and conditions in clinical diagnostics. Presently, most miRNA detection methods suffer from drawbacks, e.g., low sensitivity, long assay time, expensive equipment, trained personnel, or unsuitability for point-of-care. New methodologies are needed to overcome these limitations to allow rapid, sensitive, low-cost, easy-to-use, and portable methods for miRNA detection at the point of care. In this work, to overcome these shortcomings, we integrated capacitive sensing and alternating current electrokinetic effects to detect specific miRNA-16b molecules, as a model, with the limit of detection reaching 1.0 femto molar (fM) levels. The specificity of the sensor was verified by testing miRNA-25, which has the same length as miRNA-16b. The sensor we developed demonstrated significant improvements in sensitivity, response time and cost over other miRNA detection methods, and has application potential at point-of-care.

Sign in / Sign up

Export Citation Format

Share Document