scholarly journals Effects of exposure of adult mice to multi-walled carbon nanotubes on the liver lipid metabolism of their offspring

2018 ◽  
Vol 7 (5) ◽  
pp. 809-816 ◽  
Author(s):  
Hong-yu Zhang ◽  
Ru-long Chen ◽  
Yang Shao ◽  
Hua-lin Wang ◽  
Zhi-guo Liu
Keyword(s):  
Carbon Nanotubes ◽  
Lipid Metabolism ◽  
Liver Lipid ◽  
Adult Mice ◽  
Multi Walled Carbon Nanotubes ◽  
Liver Lipid Metabolism ◽  
Walled Carbon Nanotubes

Objective: To explore the toxicity of multi-walled carbon nanotubes (MWCNTs) on the liver lipid metabolism of offspring mice and the possible mechanisms involved.

scholarly journals Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Madlen Matz-Soja ◽  
Christiane Rennert ◽  
Kristin Schönefeld ◽  
Susanne Aleithe ◽  
Jan Boettger ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Lipid Metabolism ◽  
Liver Disease ◽  
Hepatic Steatosis ◽  
Hedgehog Signaling ◽  
Liver Lipid ◽  
Hedgehog Pathway ◽  
Alcoholic Fatty Liver ◽  
Adult Mice ◽  
Liver Lipid Metabolism

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries and is increasing in prevalence. The pathomechanisms, however, are poorly understood. This study assessed the unexpected role of the Hedgehog pathway in adult liver lipid metabolism. Using transgenic mice with conditional hepatocyte-specific deletion of Smoothened in adult mice, we showed that hepatocellular inhibition of Hedgehog signaling leads to steatosis by altering the abundance of the transcription factors GLI1 and GLI3. This steatotic 'Gli-code' caused the modulation of a complex network of lipogenic transcription factors and enzymes, including SREBP1 and PNPLA3, as demonstrated by microarray analysis and siRNA experiments and could be confirmed in other steatotic mouse models as well as in steatotic human livers. Conversely, activation of the Hedgehog pathway reversed the "Gli-code" and mitigated hepatic steatosis. Collectively, our results reveal that dysfunctions in the Hedgehog pathway play an important role in hepatic steatosis and beyond.

Multi-walled Carbon Nanotubes Penetrate into Plant Cells and Affect the Growth of Onobrychis arenaria Seedlings

Acta Naturae ◽  
2011 ◽  
Vol 3 (1) ◽  
pp. 99-106 ◽  
Author(s):  
E A Smirnova ◽  
A A Gusev ◽  
O N Zaitseva ◽  
E M Lazareva ◽  
G E Onishchenko ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Plant Cells ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Incorporation of Multi Wall Carbon Nanotubes into Glass-Surfaces via Laser-Treatment

2003 ◽  
Vol 772 ◽  
Author(s):  
T. Seeger ◽  
G. de la Fuente ◽  
W.K. Maser ◽  
A.M. Benito ◽  
A. Righi ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Continuous Wave ◽  
Silica Surface ◽  
Multi Wall Carbon Nanotubes ◽  
Composite Formation ◽  
Multi Walled Carbon Nanotubes ◽  
Glass Surfaces ◽  
Walled Carbon Nanotubes ◽  
First Time ◽  
Scanning Electron

AbstractCarbon nanotubes (CNT) are interesting candidates for the reinforcement in robust composites and for conducting fillers in polymers due to their fascinating electronic and mechanical properties. For the first time, we report the incorporation of multi walled carbon nanotubes (MWNTs) into silica-glass surfaces by means of partial surface-melting caused by a continuous wave Nd:YAG laser. MWNTs were detected being well incorporated in the silica-surface. The composites are characterized using scanning electron microscopy (SEM) and Raman-spectroscopy. A model for the composite-formation is proposed based on heatabsorption by MWNTs and a partial melting of the silica-surface.

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