Simultaneous identification and determination of eleven tyrosine kinase inhibitors by supercritical fluid chromatography-mass spectrometry

2019 ◽  
Vol 11 (16) ◽  
pp. 2211-2222
Author(s):  
Shaomin Zhang ◽  
Wei Jin ◽  
Yongjian Yang
Keyword(s):  
Mass Spectrometry ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Analytical Method ◽  
Kinase Inhibitors ◽  
Chromatography Mass Spectrometry ◽  
Simultaneous Identification

A rapid analytical method using supercritical fluid chromatography (SFC) coupled to mass spectrometry for the simultaneous identification and determination of eleven tyrosine kinase inhibitors (TKIs) was developed and validated.

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