Photothermal-modulated reversible volume transition of wireless hydrogels embedded with redox-responsive carbon dots

The reversible volume transition of redox-responsive hydrogels by NIR has attracted attention as novel therapy for tracking and treating cancer via stimuli-responsive fluorescence on/off with controllable volume transition via wireless system.

Download Full-text

Stimulus-responsive hydrogels reinforced by cellulose nanowhisker for controlled drug release

RSC Advances ◽

10.1039/c6ra14421g ◽

2016 ◽

Vol 6 (90) ◽

pp. 87422-87432 ◽

Cited By ~ 6

Author(s):

Y. Chen ◽

W. Y. Liu ◽

G. S. Zeng

Keyword(s):

Drug Release ◽

Controlled Drug Release ◽

Carboxymethyl Chitosan ◽

Stimuli Responsive ◽

Release System ◽

Cellulose Nanowhisker ◽

Hybrid Hydrogels ◽

System P ◽

Stimulus Responsive ◽

Responsive Hydrogels

Hybrid hydrogels (W–C gels), composed of PDMAEMA, cellulose nanowhisker (CNW) and carboxymethyl chitosan (CMCS), were prepared for developing a stimuli-responsive drug-release system.

Download Full-text

Natural Polymer-based Stimuli-responsive Hydrogels

Current Medicinal Chemistry ◽

10.2174/0929867326666191122144916 ◽

2020 ◽

Vol 27 (16) ◽

pp. 2631-2657 ◽

Cited By ~ 2

Author(s):

Yuheng Jiang ◽

Ying Wang ◽

Qin Li ◽

Chen Yu ◽

Wanli Chu

Keyword(s):

Natural Polymer ◽

Stimuli Responsive ◽

Medical Field ◽

Preparation Methods ◽

Polymer Hydrogels ◽

Advanced Technologies ◽

Redox Responsive ◽

Good Biocompatibility ◽

External Stimuli ◽

Responsive Hydrogels

The abilities of intelligent polymer hydrogels to change their structure and volume phase in response to external stimuli have provided new possibilities for various advanced technologies and great research and application potentials in the medical field. The natural polymer-based hydrogels have the advantages of environment-friendliness, rich sources and good biocompatibility. Based on their responsiveness to external stimuli, the natural polymer-based hydrogels can be classified into the temperature-responsive hydrogel, pH-responsive hydrogel, light-responsive hydrogel, electricresponsive hydrogel, redox-responsive hydrogel, enzyme-responsive hydrogel, magnetic-responsive hydrogel, multi-responsive hydrogel, etc. In this review, we have compiled some recent studies on natural polymer-based stimuli-responsive hydrogels, especially the hydrogels prepared from polysaccharides. The preparation methods, properties and applications of these hydrogels in the medical field are highlighted.

Download Full-text

Sticky ends in a self-assembling ABA triblock copolymer: the role of ureas in stimuli-responsive hydrogels

Molecular Systems Design & Engineering ◽

10.1039/c8me00063h ◽

2019 ◽

Vol 4 (1) ◽

pp. 91-102 ◽

Cited By ~ 5

Author(s):

Ryan T. Shafranek ◽

Joel D. Leger ◽

Song Zhang ◽

Munira Khalil ◽

Xiaodan Gu ◽

...

Keyword(s):

Self Assembly ◽

Viscoelastic Properties ◽

Triblock Copolymer ◽

Thermal Response ◽

Stimuli Responsive ◽

Self Assembling ◽

Polymeric Hydrogels ◽

Aba Triblock Copolymer ◽

Responsive Hydrogels

Directed self-assembly in polymeric hydrogels allows tunability of thermal response and viscoelastic properties.

Download Full-text

Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽

10.3390/nano11051108 ◽

2021 ◽

Vol 11 (5) ◽

pp. 1108

Author(s):

Manuela Curcio ◽

Alessandro Paolì ◽

Giuseppe Cirillo ◽

Sebastiano Di Pietro ◽

Martina Forestiero ◽

...

Keyword(s):

Cancer Therapy ◽

Drug Release ◽

Metastatic Cancer ◽

Stimuli Responsive ◽

Cancer Disease ◽

New Class ◽

Self Assembling ◽

Redox Responsive ◽

Potential Applicability ◽

Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

Download Full-text