scholarly journals Droplet microfluidics: from proof-of-concept to real-world utility?

2019 ◽  
Vol 55 (67) ◽  
pp. 9895-9903 ◽  
Author(s):  
Akkapol Suea-Ngam ◽  
Philip D. Howes ◽  
Monpichar Srisa-Art ◽  
Andrew J. deMello
Keyword(s):  
Real World ◽  
High Speed ◽  
Droplet Microfluidics ◽  
Proof Of Concept ◽  
Conventional Instrumentation ◽  
Practical Tool ◽  
Tool Set

Droplet microfluidics constitutes a diverse and practical tool set that enables chemical and biological experiments to be performed at high speed and with enhanced efficiency when compared to conventional instrumentation.

scholarly journals Multi-fidelity black-box optimization for time-optimal quadrotor maneuvers

2021 ◽  
pp. 027836492110333
Author(s):  
Gilhyun Ryou ◽  
Ezra Tal ◽  
Sertac Karaman
Keyword(s):  
Real World ◽  
High Speed ◽  
Analytical Approximation ◽  
Black Box ◽  
Bayesian Optimization ◽  
Optimization Framework ◽  
Quadrotor Aircraft ◽  
Time Optimal ◽  
Feasibility Constraints ◽  
Generation Problem

We consider the problem of generating a time-optimal quadrotor trajectory for highly maneuverable vehicles, such as quadrotor aircraft. The problem is challenging because the optimal trajectory is located on the boundary of the set of dynamically feasible trajectories. This boundary is hard to model as it involves limitations of the entire system, including complex aerodynamic and electromechanical phenomena, in agile high-speed flight. In this work, we propose a multi-fidelity Bayesian optimization framework that models the feasibility constraints based on analytical approximation, numerical simulation, and real-world flight experiments. By combining evaluations at different fidelities, trajectory time is optimized while the number of costly flight experiments is kept to a minimum. The algorithm is thoroughly evaluated for the trajectory generation problem in two different scenarios: (1) connecting predetermined waypoints; (2) planning in obstacle-rich environments. For each scenario, we conduct both simulation and real-world flight experiments at speeds up to 11 m/s. Resulting trajectories were found to be significantly faster than those obtained through minimum-snap trajectory planning.

scholarly journals Microdroplet-based system for culturing of environmental microorganisms using FNAP-sort

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kanako Saito ◽  
Yuri Ota ◽  
Dieter M. Tourlousse ◽  
Satoko Matsukura ◽  
Hirotsugu Fujitani ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
High Purity ◽  
Droplet Microfluidics ◽  
Individual Growth ◽  
Proof Of Concept ◽  
Widespread Adoption ◽  
Technical Challenges ◽  
On Chip ◽  
Uncultured Microorganisms ◽  
Environmental Microbes

AbstractDroplet microfluidics has emerged as a powerful technology for improving the culturing efficiency of environmental microorganisms. However, its widespread adoption has been limited due to considerable technical challenges, especially related to identification and manipulation of individual growth-positive droplets. Here, we combined microfluidic droplet technology with on-chip “fluorescent nucleic acid probe in droplets for bacterial sorting” (FNAP-sort) for recovery of growth-positive droplets and droplet microdispensing to establish an end-to-end workflow for isolation and culturing of environmental microbes. As a proof-of-concept, we demonstrate the ability of our technique to yield high-purity cultures of rare microorganisms from a representative complex environmental microbiome. As our system employs off-the-shelf commercially available equipment, we believe that it can be readily adopted by others and may thus find widespread use toward culturing the high proportion of as-of-yet uncultured microorganisms in different biomes.

Practicality Assessment of a Frugal Nanoparticle Generator: Opening doors to Nano Pharmaceuticals for the researchers and students of underprivileged academic institutions.

2021 ◽  
Vol 17 ◽  
Author(s):  
Swayamprakash Patel ◽  
Ashish Patel ◽  
Mruduka Patel ◽  
Umang Shah ◽  
Mehul Patel ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Organic Solvent ◽  
Ultrasonic Vibration ◽  
High Speed ◽  
Patent Application ◽  
Entrapment Efficiency ◽  
Proof Of Concept ◽  
Research Institutions ◽  
Novel Approach ◽  
Sophisticated Equipment

Background: Probe sonication and High-speed homogenizer are comparatively costly equipment to fabricate the nanoparticles. Many academic and research institutions cannot afford the procurement and maintenance of such sophisticated equipment. In the present work, a newer idea is conceptualized, which can be adopted by the underprivileged research institutions to fabricate solid lipid nanoparticles (SLN) in the absence of sophisticated equipment. The current work describes the pilot-level trials of this novel approach. This study represents the preliminary proof-of-concept trials for which the Indian patent application (3508/MUM/2015) is filed. Method: A frugal piece of equipment was made using a 50 ml centrifuge tube with conical bottom and a piezoelectric mist maker or humidifier. SLNs were prepared by combining the quasi-emulsion solvent evaporation approach and ultrasonic vibration approach. A quasi-emulsion was composed by the dropwise mixing of the organic solvent containing drug & lipid with an aqueous solution containing surfactant under continuous ultrasonic vibration in the piezoelectric chamber. The size of the droplets was significantly reduced due to piezoelectric ultrasonic vibration. Under the provision of mild vacuum and heat generated by vibration, the organic solvent was evaporated, which leaves behind a suspension of SLN. In the present work, albendazole was selected as a model drug. Various trials with Compritol 888 ATO® and Precirol ATO 5® as a lipid carrier and Tween 80 and Poloxamer 188 as a surfactant were performed. Zeta potential of SLNs was improved by the addition of polyelectrolytes like K2SO4 and Na4P2O7. Result and Conclusion: The ratio of drug to lipid was optimized to 1:4 for the most favorable results. SLN with a minimum Z-average diameter of 98.59 nm, -21 mV zeta potential, and 34.064 % (SD 10.78, n=9) entrapment efficiency were developed using the Precirol ATO 5 ® as a lipid carrier. The proof of concept for this novel approach is established through the development of Albendazole SLNs. This approach must also be evaluated for the development of polymeric nanoparticles and vesicular formulations. The further sophistication of the frugal equipment may allow more control over the quality of SLN. This approach will enable underprivileged researchers to prepare Nanopharmaceuticals. Researchers and students of such institutions can focus on the application of SLN by resolving the constraint of sophisticated equipment with this novel approach. This novel approach should also be tried for polymeric and vesicular nanopharmaceuticals.

Proof-of-concept of a risk calculator of chemotherapy induced (febrile) neutropenia (CIN/FN) based on real-world evidence (Monitor-GCSF study)

2017 ◽  
Vol 28 ◽  
pp. x161-x162
Author(s):  
C. Bokemeyer ◽  
M. Aapro ◽  
H. Ludwig ◽  
P. Gascón ◽  
M. Boccadoro ◽  
...  
Keyword(s):  
Febrile Neutropenia ◽  
Real World ◽  
Proof Of Concept ◽  
Risk Calculator ◽  
Real World Evidence

scholarly journals Development of Semi-Interface Motorcycle Simulator (SiMS)

2018 ◽  
Vol 7 (4.27) ◽  
pp. 148
Author(s):  
Wan Muhammad Syahmi Wan Fauzi ◽  
Abdul Rahman Omar ◽  
Helmi Rashid
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Real World ◽  
Computer Aided Design ◽  
High Speed ◽  
Controlled Environment ◽  
Element Analysis ◽  
Computer Aided ◽  
Niche Area ◽  
Aided Design

Recently, studies concerning motorcycle have been an overwhelming area of research interest. As an alternative to the real world assessment, researchers have utilized motorcycle simulator as a workstation to conduct studies in the motorcycle niche area. This paper deal with the development of a new motorcycle simulator named Semi-Interface Motorcycle Simulator (SiMS). Combination of Computer Aided Design (CAD) and Finite Element Analysis (FEA) software made it possible to design and simulates the motorcycle simulator’s conceptual design before being fabricated. The SiMS setup not only provides a near-to-real and immerse motorcycle riding experience on a super sport motorcycle model, but it also allows safer high speed motorcycle simulations to be conducted in a controlled environment that is portable and ergonomically easier to transport to various venues.  

A ROS-Simulink Real-Time Communication Bridge Using UDP With a Driver-in-the-Loop Application

2016 ◽  
Author(s):  
Mohamed Wahba ◽  
Robert Leary ◽  
Nicolás Ochoa-Lleras ◽  
Jariullah Safi ◽  
Sean Brennan
Keyword(s):  
Operating System ◽  
Real Time ◽  
High Speed ◽  
Performance Metrics ◽  
Proof Of Concept ◽  
Physical Separation ◽  
Robot Operating System ◽  
Time Latency ◽  
And Performance ◽  
Fast Transmission

This paper presents implementation details and performance metrics for software developed to connect the Robot Operating System (ROS) with Simulink Real-Time (SLRT). The communication takes place through the User Datagram Protocol (UDP) which allows for fast transmission of large amounts of data between the two systems. We use SLRT’s built-in UDP communication and binary packing blocks to send and receive the data over a network. We use implementation metrics from several examples to illustrate the effectiveness and drawbacks of this bridge in a real-time environment. The time latency of the bridge is analyzed by performing loop-back tests and obtaining the statistics of the time delay. A proof of concept experiment is presented that utilizes two laboratories that ran a driver-in-the-loop system despite a large physical separation. This work provides recommendations for implementing data integrity measures as well as the potential to use the system with other applications that demand high speed real-time communication.

Modeling Approach for a Fluid Movement Induced by Magnetic Forces for Viscous Loss Reduction of MRF Brakes and Clutches

2012 ◽  
Author(s):  
Dirk Güth ◽  
Markus Schamoni ◽  
Jürgen Maas
Keyword(s):  
High Speed ◽  
Complete Separation ◽  
Loss Reduction ◽  
Proof Of Concept ◽  
Idle Mode ◽  
Modeling Approach ◽  
Induced Drag ◽  
Viscous Loss ◽  
Novel Concept ◽  
Viscous Torque

A challenge that is opposed to a commercial use of actuators like brakes and clutches based on magnetorheological fluids (MRF), are durable no-load losses, because a complete torque-free separation due to the permanent liquid intervention is inherently not yet possible. In this paper, the necessity of reducing these durable no-load losses will be shown by measurements performed with a MRF brake for high rotational speeds of 6000min−1. The detrimental high viscous torque motivates the introduction of a novel concept that allows a controlled movement of the MRF from an active shear gap into an inactive shear gap, enabling a complete separation of the fluid engaging surfaces. This behavior is modeled by the use of the ferrohydrodynamics and simulations are performed for different transitions between braking and idle mode. Images of high speed video capturing, showing the motion of MRF induced by a magnetic field, are presented for the validation of the modeling approach. Measurements performed with a realized proof-of-concept actuator show that the viscous induced drag torque can be reduced significantly.

Anthropometric dependence of the response of a Thorax FE model under high speed loading: Validation and real world accident replication

2013 ◽  
Vol 110 (2) ◽  
pp. 160-170 ◽  
Author(s):  
Sébastien Roth ◽  
Fabien Torres ◽  
Philippe Feuerstein ◽  
Karine Thoral-Pierre
Keyword(s):  
Real World ◽  
High Speed ◽  
Fe Model
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