An integrated targeting drug delivery system based on the hybridization of graphdiyne and MOFs for visualized cancer therapy

Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to address these issues and bring new hope for cancer treatment. In this context, we established an original nanomicellar drug delivery system based on an amphiphilic dendrimer (AmDM), which could generate supramolecular micelles to effectively encapsulate the anticancer drug doxorubicin (DOX) with high drug-loading capacity (>40%), thanks to the unique dendritic structure creating large void space for drug accommodation. The resulting AmDM/DOX nanomicelles were able to enhance drug potency and combat doxorubicin resistance in breast cancer models by significantly enhancing cellular uptake while considerably decreasing efflux of the drug. In addition, the AmDM/DOX nanoparticles abolished significantly the toxicity related to the free drug. Collectively, our studies demonstrate that the drug delivery system based on nanomicelles formed with the self-assembling amphiphilic dendrimer constitutes a promising and effective drug carrier in cancer therapy.

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Pluronic F127 self-assembled MoS2 nanocomposites as an effective glutathione responsive anticancer drug delivery system

RSC Advances ◽

10.1039/c9ra04249k ◽

2019 ◽

Vol 9 (44) ◽

pp. 25592-25601 ◽

Cited By ~ 4

Author(s):

Adhisankar Vadivelmurugan ◽

Rajeshkumar Anbazhagan ◽

Vinothini Arunagiri ◽

Juin-Yih Lai ◽

Hsieh-Chih Tsai

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery System ◽

Anticancer Drug ◽

Delivery System ◽

Drug Carrier ◽

Pluronic F127 ◽

Anticancer Drug Delivery ◽

System P ◽

Self Assembled

In this study, bio-responsive polymeric MoS2 nanocomposites were prepared for use as a drug carrier for cancer therapy.

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Preparation and evaluation of gemcitabin and cisplatin-entrapped Folate-PEGylated liposomes as targeting co-drug delivery system in cancer therapy

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2021.102756 ◽

2021 ◽

pp. 102756

Author(s):

Pooneh Pakdaman Goli ◽

Maryam Bikhof Torbati ◽

Kazem Parivar ◽

Azim Akbarzadeh Khiavi ◽

Mohammad Yousefi

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery System ◽

Delivery System ◽

Pegylated Liposomes ◽

Preparation And Evaluation

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Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1714421115 ◽

2018 ◽

Vol 115 (3) ◽

pp. 501-506 ◽

Cited By ~ 356

Author(s):

Meng Qiu ◽

Dou Wang ◽

Weiyuan Liang ◽

Liping Liu ◽

Yin Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Near Infrared ◽

Black Phosphorus ◽

Deep Penetration ◽

Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

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Environment Responsive Metal–Organic Frameworks as Drug Delivery System for Tumor Therapy

Nanoscale Research Letters ◽

10.1186/s11671-021-03597-w ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Chao Yan ◽

Yue Jin ◽

Chuanxiang Zhao

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Tumor Therapy ◽

Metal Organic Frameworks ◽

Delivery Systems ◽

Drug Uptake ◽

High Concentration ◽

Metal Organic

AbstractNanoparticles as drug delivery systems can alter the drugs' hydrophilicity to affect drug uptake and efflux in tissues. They prevent drugs from non-specifically binding with bio-macromolecules and enhance drug accumulation at the lesion sites, improving therapy effects and reducing unnecessary side effects. Metal–organic frameworks (MOFs), the typical nanoparticles, a class of crystalline porous materials via self-assembled organic linkers and metal ions, exhibit excellent biodegradability, pore shape and sizes, and finely tunable chemical composition. MOFs have a rigid molecular structure, and tunable pore size can improve the encapsulation drug's stability under harsh conditions. Besides, the surface of MOFs can be modified with small-molecule ligands and biomolecule, and binding with the biomarkers which is overexpressed on the surface of cancer cells. MOFs formulations for therapeutic have been developed to effectively respond to the unique tumor microenvironment (TEM), such as high H2O2 levels, hypoxia, and high concentration glutathione (GSH). Thus, MOFs as a drug delivery system should avoid drugs leaking during blood circulation and releasing at the lesion sites via a controlling manner. In this article, we will summary environment responsive MOFs as drug delivery systems for tumor therapy under different stimuli.

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Functionalized halloysite nanotube by chitosan grafting for drug delivery of curcumin to achieve enhanced anticancer efficacy

Journal of Materials Chemistry B ◽

10.1039/c5tb02725j ◽

2016 ◽

Vol 4 (13) ◽

pp. 2253-2263 ◽

Cited By ~ 115

Author(s):

Mingxian Liu ◽

Yanzhou Chang ◽

Jing Yang ◽

Yuanyuan You ◽

Rui He ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery System ◽

Delivery System ◽

Halloysite Nanotube ◽

Anticancer Efficacy

A new HNTs-based drug delivery system to improve the bioavailability of curcumin for cancer therapy is proposed.

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Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

Nanotechnology Reviews ◽

10.1515/ntrev-2018-0029 ◽

2018 ◽

Vol 7 (4) ◽

pp. 291-301 ◽

Cited By ~ 16

Author(s):

Zepeng Jiao ◽

Bin Zhang ◽

Chunya Li ◽

Weicong Kuang ◽

Jingxian Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Graphene Oxide ◽

Drug Delivery System ◽

Delivery System ◽

Carboxymethyl Cellulose ◽

Drug Carrier ◽

Controlled Drug Release ◽

Ph Sensitive ◽

Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

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