scholarly journals The effects of aloe emodin-mediated antimicrobial photodynamic therapy on drug-sensitive and resistant Candida albicans

2020 ◽  
Vol 19 (4) ◽  
pp. 485-494 ◽  
Author(s):  
Wenpeng Ma ◽  
Chengcheng Liu ◽  
Jiao Li ◽  
Ming Hao ◽  
Yanhong Ji ◽  
...  
Keyword(s):  
Cell Wall ◽  
Candida Albicans ◽  
Photodynamic Therapy ◽  
Antimicrobial Photodynamic Therapy ◽  
Aloe Emodin

Aloe emodin-mediated antimicrobial photodynamic therapy effectively inactivated drug-sensitive and resistant C. albicans and caused damage to the cell wall, cytoplasm, and nucleus.

Copolymer-nanocapsules of zinc phenyl-thio-phthalocyanine and amphotericin-B in association with antimicrobial photodynamic therapy (A-PDT) applications against Candida albicans yeasts

2021 ◽  
Vol 34 ◽  
pp. 102273
Author(s):  
Rodrigo P. Evangelista ◽  
Camila F. Amantino ◽  
Rosemeire C.L.R. Pietro ◽  
Rodrigo Sorrechia ◽  
Rodolfo D. Piazza ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Photodynamic Therapy ◽  
Amphotericin B ◽  
Antimicrobial Photodynamic Therapy

DNase increases the efficacy of antimicrobial photodynamic therapy on Candida albicans biofilms

2019 ◽  
Vol 27 ◽  
pp. 124-131 ◽  
Author(s):  
Beatriz H.D. Panariello ◽  
Marlise I. Klein ◽  
Fernanda Alves ◽  
Ana Cláudia Pavarina
Keyword(s):  
Candida Albicans ◽  
Photodynamic Therapy ◽  
Antimicrobial Photodynamic Therapy ◽  
Candida Albicans Biofilms

scholarly journals Spatial Distribution of a Porphyrin-Based Photosensitizer Reveals Mechanism of Photodynamic Inactivation of Candida albicans

2021 ◽  
Vol 8 ◽  
Author(s):  
Thomas Voit ◽  
Fabian Cieplik ◽  
Johannes Regensburger ◽  
Karl-Anton Hiller ◽  
Anita Gollmer ◽  
...  
Keyword(s):  
Cell Wall ◽  
Candida Albicans ◽  
Fungal Infections ◽  
Cell Envelope ◽  
Antimicrobial Photodynamic Therapy ◽  
Fungal Cell ◽  
Before And After ◽  
Antifungal Action ◽  
Complete Cell ◽  
Further Development

The antimicrobial photodynamic therapy (aPDT) is a promising approach for the control of microbial and especially fungal infections such as mucosal mycosis. TMPyP [5,10,15, 20-tetrakis(1-methylpyridinium-4-yl)-porphyrin tetra p-toluenesulfonate] is an effective photosensitizer (PS) that is commonly used in aPDT. The aim of this study was to examine the localization of TMPyP in Candida albicans before and after irradiation with visible light to get information about the cellular mechanism of antifungal action of the photodynamic process using this PS. Immediately after incubation of C. albicans with TMPyP, fluorescence microscopy revealed an accumulation of the PS in the cell envelope. After irradiation with blue light the complete cell showed red fluorescence, which indicates, that aPDT is leading to a damage in the cell wall with following influx of PS into the cytosol. Incubation of C. albicans with Wheat Germ Agglutinin (WGA) could confirm the cell wall as primary binding site of TMPyP. The finding that the porphyrin accumulates in the fungal cell wall and does not enter the interior of the cell before irradiation makes it unlikely that resistances can emerge upon aPDT. The results of this study may help in further development and modification of PS in order to increase efficacy against fungal infections such as those caused by C. albicans.

scholarly journals Antimicrobial Photodynamic Therapy in Combination with Nystatin in the Treatment of Experimental Oral Candidiasis Induced by Candida albicans Resistant to Fluconazole

2019 ◽  
Vol 12 (3) ◽  
pp. 140 ◽  
Author(s):  
Karem Janeth Rimachi Hidalgo ◽  
Juliana Cabrini Carmello ◽  
Cláudia Carolina Jordão ◽  
Paula Aboud Barbugli ◽  
Carlos Alberto de Sousa Costa ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Photodynamic Therapy ◽  
Combined Therapy ◽  
Oral Candidiasis ◽  
Confocal Scanning Laser Microscopy ◽  
Antimicrobial Photodynamic Therapy ◽  
Promising Alternative ◽  
Confocal Scanning ◽  
Confocal Scanning Laser

Background: It has been demonstrated that azole-resistant strains of Candida albicans have a greater resistance to antimicrobial photodynamic therapy (aPDT) when compared to their more susceptible counterparts. For this reason, the present study evaluated the efficacy of aPDT, together with nystatin (NYS), in the treatment of oral candidiasis in vivo. Methods: Mice were infected with fluconazole-resistant C. albicans (ATCC 96901). To perform the combined therapy, aPDT, mediated by Photodithazine (PDZ) and LED light, was used together with NYS. The efficacy of the treatments was evaluated by microbiological, macroscopic, histopathological and Confocal Scanning Laser Microscopy analyses of the lesions. The expression of p21 and p53, proteins associated with cell death, from the tongues of mice, was also performed. Results: The combined therapy reduced the fungal viability by around 2.6 log10 and decreased the oral lesions and the inflammatory reaction. Additionally, it stimulated the production of p53 and p21. Conclusions: The combined therapy is a promising alternative treatment for oral candidiasis induced by C. albicans resistant to fluconazole.

scholarly journals Application of benzo[a]phenoxazinium chlorides in antimicrobial photodynamic therapy of Candida albicans biofilms

2014 ◽  
Vol 141 ◽  
pp. 93-99 ◽  
Author(s):  
Marisa Lopes ◽  
Carlos Tiago Alves ◽  
B. Rama Raju ◽  
M. Sameiro T. Gonçalves ◽  
Paulo J.G. Coutinho ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Photodynamic Therapy ◽  
Antimicrobial Photodynamic Therapy ◽  
Candida Albicans Biofilms

scholarly journals Action of antimicrobial photodynamic therapy on heterotypic biofilm: Candida albicans and Bacillus atrophaeus

2016 ◽  
Vol 31 (4) ◽  
pp. 605-610 ◽  
Author(s):  
Michelle Peneluppi Silva ◽  
Thais Alves dos Santos ◽  
Patrícia Pimentel de Barros ◽  
Felipe de Camargo Ribeiro ◽  
Juliana Campos Junqueira ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Photodynamic Therapy ◽  
Antimicrobial Photodynamic Therapy ◽  
Bacillus Atrophaeus

scholarly journals Antimicrobial photodynamic therapy in rat experimental candidiasis: evaluation of pathogenicity factors of Candida albicans

2011 ◽  
Vol 111 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Joyce da Silva Martins ◽  
Juliana Campos Junqueira ◽  
Raquel Lourdes Faria ◽  
Naiara Fonseca Santiago ◽  
Rodnei Dennis Rossoni ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Photodynamic Therapy ◽  
Antimicrobial Photodynamic Therapy ◽  
Pathogenicity Factors

scholarly journals Aloe‐emodin‐mediated antimicrobial photodynamic therapy against dermatophytosis caused by Trichophyton rubrum

2021 ◽  
Author(s):  
Wenpeng Ma ◽  
Miaomiao Zhang ◽  
Zixin Cui ◽  
Xiaopeng Wang ◽  
Xinwu Niu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Trichophyton Rubrum ◽  
Antimicrobial Photodynamic Therapy ◽  
Aloe Emodin
Sign in / Sign up

Export Citation Format

Share Document