Nisin/polyanion layer-by-layer films exhibiting different mechanisms in antimicrobial efficacy

Polyanion–nisin multilayer films exhibit antimicrobial activity by controlled release of nisin or as stable biofilm inhibiting coatings depending on polyanion.

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A Novel Layer-by-Layer Approach for the Fabrication of Conducting Polymer/RNA Multilayer Films for Controlled Release

Langmuir ◽

10.1021/la053031m ◽

2006 ◽

Vol 22 (6) ◽

pp. 2811-2815 ◽

Cited By ~ 45

Author(s):

Carmen L. Recksiedler ◽

Bhavana A. Deore ◽

Michael S. Freund

Keyword(s):

Controlled Release ◽

Conducting Polymer ◽

Multilayer Films ◽

Layer By Layer

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Antimicrobial Activities of Hydrophobically Modified Poly(Acrylate) Films and Their Complexes with Different Chain Length Cationic Surfactants

Coatings ◽

10.3390/coatings9040244 ◽

2019 ◽

Vol 9 (4) ◽

pp. 244

Author(s):

Ioana Cătălina Gîfu ◽

Monica Elisabeta Maxim ◽

Ludmila Otilia Cinteza ◽

Marcela Popa ◽

Ludmila Aricov ◽

...

Keyword(s):

Antimicrobial Activity ◽

Cationic Surfactants ◽

Antimicrobial Properties ◽

Multilayer Films ◽

Antimicrobial Activities ◽

Layer By Layer ◽

Antimicrobial Efficiency ◽

Hydrophobically Modified ◽

Multilayered Systems ◽

The Stability

Multilayer films from hydrophobically modified poly(acrylic acid) (HMPA) and their complexes with cationic surfactants were successfully prepared using the layer-by-layer (LbL) method. Alkyl trimethylammonium bromide derivatives with various lengths of the hydrophobic chain (C10–C18) were used to interact with the HMPA polymer, generating highly hydrophobic domains in the films and contributing to the antimicrobial properties of the prepared coating. The antimicrobial efficiency against common pathogens such as Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans was investigated in relationship with the morphology and composition of the thin films. The wettability and roughness of the multilayered systems were evaluated using atomic force microscopy (AFM) and contact angle measurements. The effects of the microbial exposure on the surface properties of the prepared films were investigated in order to assess the stability of the HMPA-deposited multilayers and the durability of the antimicrobial activity. The hydrophobically modified films exhibited antimicrobial activity against the studied pathogens. The best efficiency was registered in the case of S. aureus, which showed an inhibition of growth up to 100% after 2 h. C. albicans proved to be less sensitive to the effect of the multilayers deposited from HMPA–surfactant complexes. These results suggest that HMPA and HMPA–surfactant complex LbL multilayer films can be used as promising materials in antimicrobial surface coatings with increased resistance to pathogens during exposure.

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Dendronized polymer as building block for layer-by-layer assembly: Polyelectrolyte multilayer films for incorporation and controlled release of water-insoluble dye

Polymer ◽

10.1016/j.polymer.2008.01.064 ◽

2008 ◽

Vol 49 (6) ◽

pp. 1520-1526 ◽

Cited By ~ 19

Author(s):

Qing Jiao ◽

Zhuo Yi ◽

Yongming Chen ◽

Fu Xi

Keyword(s):

Controlled Release ◽

Building Block ◽

Multilayer Films ◽

Layer By Layer ◽

Polyelectrolyte Multilayer ◽

Layer By Layer Assembly ◽

Dendronized Polymer ◽

Layer Assembly

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Encapsulation of Essential Oils within a Polymeric Liposomal Formulation for Enhancement of Antimicrobial Efficacy

Natural Product Communications ◽

10.1177/1934578x1000500912 ◽

2010 ◽

Vol 5 (9) ◽

pp. 1934578X1000500 ◽

Cited By ~ 7

Author(s):

Sandy F. van Vuuren ◽

Lisa C. du Toit ◽

Ashleigh Parry ◽

Viness Pillay ◽

Yahya E. Choonara

Keyword(s):

Antimicrobial Activity ◽

Essential Oils ◽

Polymer Coating ◽

Chitosan Solution ◽

Antimicrobial Efficacy ◽

Polymeric Coating ◽

Limiting Factor ◽

Layer By Layer ◽

Positive Effects ◽

The Stability

Essential oils and their constituents are known to possess antimicrobial activity; however, their inherent volatility is a limiting factor. In order to exploit the antimicrobial efficacy of essential oils, encapsulation within polymeric liposomal systems was undertaken. The liposomes were subsequently polymer-coated in order to further enhance the stability of the formulations. Essential oils distilled from Artemisia Afra, Eucalyptus Globulus and Melaleuca alternifolia were encapsulated into diastearoyl phosphatidylcholine and diastearoyl phosphatidylethanolamine liposomes employing a reverse phase evaporation methodology. A polyelectrolyte coating was then applied via the layer-by-layer self-deposition technique. A batch of the liposomes was polymer-coated with a 0.15%w/v chitosan solution. Using the minimum inhibitory concentration assay, the liposome-encapsulated, unencapsulated and polymer-coated liposome-encapsulated essential oils were compared in order to observe whether the antimicrobial efficacy was improved with encapsulation and polymer coating. Fractional inhibitory concentrations (FICs) were calculated in order to determine the antimicrobial interactions amongst the lipoid components, polymer coating and essential oils (synergistic, additive, indifferent and antagonistic interactions). With the exception of A. afra, microbial growth was inhibited at lower concentrations for the encapsulated formulations in comparison with the non-encapsulated oils. Synergistic to additive interactions were noted for encapsulated E. globulus (ΣFIC values 0.25-0.45) and M. alternifolia (ΣFIC values 0.26-0.52) formulations. The addition of the polymer coating did not enhance antimicrobial activity, but owing to their positive effects on membrane stability, its presence is important as a means of extending the shelf life of these formulations. Additionally, the presence of the polymeric coating availed the essential oil at a slower rate. This investigation is a stepping stone towards the promotion of the antimicrobial use of essential oils. The added benefits are that essential oils not only provide effective antimicrobial efficacy, but also promote a “greener” consumerism. Within liposomes, they will enhance dermato-cosmetic properties and increase the marketing image of the final product.

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Temperature-Responsive Multilayer Films of Micelle-Based Composites for Controlled Release of a Third-Generation EGFR Inhibitor

ACS Applied Polymer Materials ◽

10.1021/acsapm.9b01051 ◽

2020 ◽

Vol 2 (2) ◽

pp. 741-750 ◽

Cited By ~ 20

Author(s):

Li Xu ◽

Hailong Wang ◽

Zihan Chu ◽

Lawrence Cai ◽

Haifeng Shi ◽

...

Keyword(s):

Controlled Release ◽

Multilayer Films ◽

Third Generation ◽

Egfr Inhibitor ◽

Temperature Responsive

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Layer-by-layer Thin Films and Microcapsules for Biosensors and Controlled Release

Analytical Sciences ◽

10.2116/analsci.28.929 ◽

2012 ◽

Vol 28 (10) ◽

pp. 929-938 ◽

Cited By ~ 59

Author(s):

Katsuhiko SATO ◽

Shigehiro TAKAHASHI ◽

Jun-ichi ANZAI

Keyword(s):

Thin Films ◽

Controlled Release ◽

Layer By Layer

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Layer-by-layer assembly of multilayer films for controlled drug release

Archives of Pharmacal Research ◽

10.1007/s12272-013-0289-x ◽

2013 ◽

Vol 37 (1) ◽

pp. 79-87 ◽

Cited By ~ 29

Author(s):

Daheui Choi ◽

Jinkee Hong

Keyword(s):

Drug Release ◽

Controlled Drug Release ◽

Multilayer Films ◽

Layer By Layer ◽

Layer By Layer Assembly ◽

Layer Assembly

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Pectin-Chitosan Multilayer Coated Microbeads of Diclofenac Sodium Prepared by Layer-by-Layer Technique

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1060.45 ◽

2014 ◽

Vol 1060 ◽

pp. 45-49

Author(s):

Kamonrak Cheewatanakornkool ◽

Pornsak Sriamornsak

Keyword(s):

Controlled Release ◽

Drug Release ◽

Diclofenac Sodium ◽

Gastric Fluid ◽

Layer By Layer ◽

Release Behavior ◽

Freeze Dried ◽

Layer Technique ◽

Calcium Pectinate ◽

Layer By Layer Technique

The main objective of this study was to fabricate biopolymer-based microbeads, providing enteric properties and controlled release of diclofenac sodium, using layer-by-layer technique. The calcium pectinate microbeads have been designed and coated with chitosan and pectin multilayers. Drug release was performed in simulate gastric fluid (pH 1.2) for 2 hours, followed by pH 6.8 buffer for 8 hours. The effects of chitosan concentration, number of layer and drying technique on drug release were investigated. The results showed that the calcium pectinate microbeads could be simply prepared by ionotropic gelation and then coated with chitosan and pectin solutions using layer-by-layer procedure. The diameter of the microbeads ranged from 800 to 1000 μm for air-dried samples and from 1 to 2 mm for freeze-dried samples. The freeze-dried microbeads had a rough surface and many pores inside, as observed by SEM. The microbeads coated with 4% chitosan/4% pectin revealed a slower drug release than those coated with 1% chitosan/4% pectin and demonstrated a controlled release pattern. Moreover, different drying techniques and numbers of layer also influenced drug release behavior of the prepared microbeads.

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Multilayer composite beads constructed via layer-by-layer self-assembly for lysozyme controlled release

RSC Advances ◽

10.1039/c4ra02780a ◽

2014 ◽

Vol 4 (46) ◽

pp. 24369-24376 ◽

Cited By ~ 10

Author(s):

Jiemin Zhao ◽

Xiaoping Wang ◽

Yanshen Kuang ◽

Yufeng Zhang ◽

Xiaowen Shi ◽

...

Keyword(s):

Controlled Release ◽

Self Assembly ◽

Cross Linking ◽

Layer By Layer ◽

Multilayer Composite ◽

Composite Beads ◽

Assembly Technique ◽

Positively Charged

Alginate (ALG)–lysozyme (LZ) beads were fabricated by a cross-linking process. Negatively charged ALG and positively charged LZ were alternately deposited on the positively charged ALG–LZ beads via a layer-by-layer (LBL) self-assembly technique.

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