scholarly journals Restricted suitability of BODIPY for caging in biological applications based on singlet oxygen generation

2020 ◽  
Vol 19 (10) ◽  
pp. 1319-1325 ◽  
Author(s):  
Theo Rodat ◽  
Melanie Krebs ◽  
Alexander Döbber ◽  
Björn Jansen ◽  
Anja Steffen-Heins ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Singlet Oxygen ◽  
Cancer Cell ◽  
Biological Applications ◽  
Biological Characterization ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Photochemical analysis and biological characterization in vitro revealed not only significant limitations of the BODIPY-caged inhibitor concept regarding uncaging in aqueous solution, but also promising cancer cell treatment through photodynamic effects.

In vitro assay of singlet oxygen generation in the presence of water-soluble derivatives of C60

Carbon ◽  
2004 ◽  
Vol 42 (5-6) ◽  
pp. 1195-1198 ◽  
Author(s):  
Bertrand Vileno ◽  
Andrzej Sienkiewicz ◽  
Małgorzata Lekka ◽  
Andrzej J. Kulik ◽  
László Forró
Keyword(s):  
Singlet Oxygen ◽  
In Vitro Assay ◽  
Water Soluble ◽  
Vitro Assay ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Derivatives Of

Synthesis of porphyrin-incorporated covalent organic frameworks for sonodynamic therapy

2021 ◽  
Author(s):  
Sainan Liu ◽  
Ying Zhou ◽  
Chunling Hu ◽  
Lihan Cai ◽  
Zhendong Liu ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Room Temperature ◽  
Covalent Organic Frameworks ◽  
Sonodynamic Therapy ◽  
Oxygen Generation ◽  
Covalent Organic Framework ◽  
Singlet Oxygen Generation ◽  
Organic Framework

Porphyrin-incorporated covalent organic framework was synthesized at room temperature. The resulting product with uniform morphology and excellent crystallinity exhibited good singlet oxygen generation ability. Both in vitro and in vivo...

scholarly journals Singlet oxygen generation from Li+@C60nano-aggregates dispersed by laser irradiation in aqueous solution

2015 ◽  
Vol 51 (38) ◽  
pp. 8082-8085 ◽  
Author(s):  
Kei Ohkubo ◽  
Naoki Kohno ◽  
Yusuke Yamada ◽  
Shunichi Fukuzumi
Keyword(s):  
Aqueous Solution ◽  
Singlet Oxygen ◽  
Laser Irradiation ◽  
Lithium Ion ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Lithium ion encapsulated fullerene was solubilised in water by laser irradiation, acting as a photosensitiser for singlet oxygen generation.

Rose Bengal-Grafted Biodegradable Microcapsules: Singlet-Oxygen Generation and Cancer-Cell Incapacitation

2011 ◽  
Vol 17 (40) ◽  
pp. 11223-11229 ◽  
Author(s):  
Xiao-Lei Wang ◽  
Yu Zeng ◽  
Yan-Zhen Zheng ◽  
Jian-Feng Chen ◽  
Xia Tao ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Cancer Cell ◽  
Rose Bengal ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

pH Controlled Intersystem Crossing and Singlet Oxygen Generation of 8-Azaadenine in Aqueous Solution

ChemPhysChem ◽  
2019 ◽  
Vol 20 (5) ◽  
pp. 757-765 ◽  
Author(s):  
Zhongneng Zhou ◽  
Zhubin Hu ◽  
Xianwang Zhang ◽  
Menghui Jia ◽  
Xueli Wang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Singlet Oxygen ◽  
Intersystem Crossing ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Ph Controlled

scholarly journals Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Mohammad Tavakkoli Yaraki ◽  
Min Wu ◽  
Eshu Middha ◽  
Wenbo Wu ◽  
Soroosh Daqiqeh Rezaei ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Enhancement Factor ◽  
Fluorescence Emission ◽  
Localized Surface Plasmon ◽  
Enhanced Fluorescence ◽  
Oxygen Generation ◽  
Image Guided ◽  
Singlet Oxygen Generation

AbstractDual-functional aggregation-induced photosensitizers (AIE-PSs) with singlet oxygen generation (SOG) ability and bright fluorescence in aggregated state have received much attention in image-guided photodynamic therapy (PDT). However, designing an AIE-PS with both high SOG and intense fluorescence via molecular design is still challenging. In this work, we report a new nanohybrid consisting of gold nanostar (AuNS) and AIE-PS dots with enhanced fluorescence and photosensitization for theranostic applications. The spectral overlap between the extinction of AuNS and fluorescence emission of AIE-PS dots (665 nm) is carefully selected using five different AuNSs with distinct localized surface plasmon (LSPR) peaks. Results show that all the AuNSs can enhance the 1O2 production of AIE-PS dots, among which the AuNS with LSPR peak at 585 nm exhibited the highest 1O2 enhancement factor of 15-fold with increased fluorescence brightness. To the best of our knowledge, this is the highest enhancement factor reported for the metal-enhanced singlet oxygen generation systems. The Au585@AIE-PS nanodots were applied for simultaneous fluorescence imaging and photodynamic ablation of HeLa cancer cells with strongly enhanced PDT efficiency in vitro. This study provides a better understanding of the metal-enhanced AIE-PS nanohybrid systems, opening up new avenue towards advanced image-guided PDT with greatly improved efficacy.

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