Synthesis of porphyrin-incorporated covalent organic frameworks for sonodynamic therapy

2021 ◽  
Author(s):  
Sainan Liu ◽  
Ying Zhou ◽  
Chunling Hu ◽  
Lihan Cai ◽  
Zhendong Liu ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Room Temperature ◽  
Covalent Organic Frameworks ◽  
Sonodynamic Therapy ◽  
Oxygen Generation ◽  
Covalent Organic Framework ◽  
Singlet Oxygen Generation ◽  
Organic Framework

Porphyrin-incorporated covalent organic framework was synthesized at room temperature. The resulting product with uniform morphology and excellent crystallinity exhibited good singlet oxygen generation ability. Both in vitro and in vivo...

scholarly journals In vivo oral insulin delivery via covalent organic frameworks

2021 ◽  
Author(s):  
Farah Benyettou ◽  
Nawel Kaddour ◽  
Thirumurugan Prakasam ◽  
Gobinda Das ◽  
Sudhir Kumar Sharma ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Insulin Delivery ◽  
Oral Insulin ◽  
Covalent Organic Frameworks ◽  
Covalent Organic Framework ◽  
Organic Framework

We report the successful use of a gastro-resistant covalent organic framework for in vivo oral delivery of insulin.

Singlet oxygen generation by sonication using a water-soluble fullerene (C60) complex: a potential application for sonodynamic therapy

2020 ◽  
Vol 52 (12) ◽  
pp. 1387-1394
Author(s):  
Thi Lien Nguyen ◽  
Risa Katayama ◽  
Chie Kojima ◽  
Akikazu Matsumoto ◽  
Kazuhiko Ishihara ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Potential Application ◽  
Fullerene C60 ◽  
Water Soluble ◽  
Sonodynamic Therapy ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

In vitro assay of singlet oxygen generation in the presence of water-soluble derivatives of C60

Carbon ◽  
2004 ◽  
Vol 42 (5-6) ◽  
pp. 1195-1198 ◽  
Author(s):  
Bertrand Vileno ◽  
Andrzej Sienkiewicz ◽  
Małgorzata Lekka ◽  
Andrzej J. Kulik ◽  
László Forró
Keyword(s):  
Singlet Oxygen ◽  
In Vitro Assay ◽  
Water Soluble ◽  
Vitro Assay ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Derivatives Of

Riboflavin-Based Carbon Dots with High Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Juan Yue ◽  
Li Li ◽  
Chenyu Jiang ◽  
Qian Mei ◽  
Wen-Fei Dong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Effective Treatment ◽  
Carbon Dots ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Photodynamic therapy, as an effective treatment for superficial tumors, has attracted more and more attention. The development of safe, biocompatible and in vivo photosensitive materials is helpful to promote photodynamic...

Photophysical properties and study of the singlet oxygen generation of tetraphenylporphyrinato palladium(II) complexes

2013 ◽  
Vol 17 (10) ◽  
pp. 964-971 ◽  
Author(s):  
Pınar Şen ◽  
Catherine Hirel ◽  
Ayşe-Gül Gürek ◽  
Chantal Andraud ◽  
Yann Bretonnière ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Room Temperature ◽  
Singlet State ◽  
Photophysical Properties ◽  
Spin Transfer ◽  
Excited Singlet ◽  
Excitation Spectra ◽  
X Ray ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Three differently substituted Pd-tetraphenyl-porphyrins complexes were synthesized and their X-ray crystal and photophysical properties were studied. All compounds display intense phosphorescence in de-aerated solutions at room temperature with decay time in the μs range. An efficient spin transfer to oxygen in aerated solutions was monitored using singlet oxygen (1 O 2) luminescence at 1275 nm. For all compounds, the quantum efficiency for generating singlet oxygen was found to be close to unity. Interesting differences in the pathways from the excited singlet state to singlet oxygen via the intermediate triplet state were observed. The excitation spectra obtained while recording the phosphorescence at 1275 nm closely matched the absorption spectra with two bands: the Soret (or B) band near 410–420 nm and a split Q-band at 510–520 nm. Noticeable differences in the B/Q intensity ratio between the absorption and excitation spectra (for both phosphorescence and singlet oxygen luminescence) were determined, indicating different Sx → T1 pathways.

scholarly journals Restricted suitability of BODIPY for caging in biological applications based on singlet oxygen generation

2020 ◽  
Vol 19 (10) ◽  
pp. 1319-1325 ◽  
Author(s):  
Theo Rodat ◽  
Melanie Krebs ◽  
Alexander Döbber ◽  
Björn Jansen ◽  
Anja Steffen-Heins ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Singlet Oxygen ◽  
Cancer Cell ◽  
Biological Applications ◽  
Biological Characterization ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Photochemical analysis and biological characterization in vitro revealed not only significant limitations of the BODIPY-caged inhibitor concept regarding uncaging in aqueous solution, but also promising cancer cell treatment through photodynamic effects.

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