Phenylboronic Acid-based Core-Shell Drug Delivery Platform Clasping 1,3-Dicarbonyl Compounds by A Coordinate Interaction

Biomaterials Science ◽

10.1039/d1bm01169c ◽

2021 ◽

Author(s):

Sungjin Jung ◽

Junseok Lee ◽

Won Jong Kim

Keyword(s):

Drug Delivery ◽

Natural Compound ◽

Phenylboronic Acid ◽

Natural Compounds ◽

Clinical Applications ◽

Core Shell ◽

Dicarbonyl Compounds ◽

Delivery Platform

Along with the successful commercialization of chemotherapeutics, such as doxorubicin and paclitaxel, numerous natural compounds have been investigated for clinical applications. Recently, curcumin (CUR), a natural compound with various therapeutic...

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Core–shell-type lipid–polymer hybrid nanoparticles as a drug delivery platform

Nanomedicine Nanotechnology Biology and Medicine ◽

10.1016/j.nano.2012.11.010 ◽

2013 ◽

Vol 9 (4) ◽

pp. 474-491 ◽

Cited By ~ 215

Author(s):

Bivash Mandal ◽

Himanshu Bhattacharjee ◽

Nivesh Mittal ◽

Hongkee Sah ◽

Pavan Balabathula ◽

...

Keyword(s):

Drug Delivery ◽

Hybrid Nanoparticles ◽

Core Shell ◽

Polymer Hybrid ◽

Shell Type ◽

Delivery Platform

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Effective Dispensing Methods for Loading Drugs Only to the Tip of DNA Microneedles

Pharmaceutics ◽

10.3390/pharmaceutics12100954 ◽

2020 ◽

Vol 12 (10) ◽

pp. 954

Author(s):

Moonjeong Bok ◽

Zhi-Jun Zhao ◽

Soon Hyoung Hwang ◽

Hyeok-Joong Kang ◽

Sohee Jeon ◽

...

Keyword(s):

Drug Delivery ◽

Manufacturing Process ◽

Fluorescein Isothiocyanate ◽

Clinical Applications ◽

Simple Method ◽

Molecular Weights ◽

Micro Nozzle ◽

Rapid Loading ◽

Apparent Diffusion ◽

Delivery Platform

Here, we propose a novel and simple method to efficiently capture the diffusion of fluorescein isothiocyanate (FITC)-dextran from a biocompatible substance and load the drug only to the tip of DNA microneedles. A dispensing and suction method was chosen to fabricate the designed microneedles with efficient amounts of FITC as the drug model. Importantly, the vacuum process, which could influence the capturing of FITC diffusion from the tip, was evaluated during the manufacturing process. In addition, the simulations were consistent with the experimental results and showed apparent diffusion. Moreover, dextrans of different molecular weights labeled with FITC were chosen to fabricate the tip of microneedles for demonstrating their applicability. Finally, a micro-jetting system with a micro-nozzle (diameter: 80 μm) was developed to achieve the accurate and rapid loading of small amounts of FITC using the anti-diffusion and micro-jetting methods. Our method not only uses a simple and fast manufacturing process, but also fabricates the tips of microneedles more efficiently with FITC compared with the existing methods. We believe that the proposed method is essential for the clinical applications of the microneedle drug delivery platform.

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Core–Shell Fibers: Design, Roles, and Controllable Release Strategies in Tissue Engineering and Drug Delivery

Polymers ◽

10.3390/polym11122008 ◽

2019 ◽

Vol 11 (12) ◽

pp. 2008 ◽

Cited By ~ 14

Author(s):

Muhammad Faiq Abdullah ◽

Tamrin Nuge ◽

Andri Andriyana ◽

Bee Chin Ang ◽

Farina Muhamad

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Clinical Applications ◽

Bioactive Molecules ◽

Core Shell ◽

Therapeutic Effects ◽

Design Requirement ◽

Preparation Methods ◽

Controllable Release ◽

Future Direction

The key attributes of core–shell fibers are their ability to preserve bioactivity of incorporated-sensitive biomolecules (such as drug, protein, and growth factor) and subsequently control biomolecule release to the targeted microenvironments to achieve therapeutic effects. Such qualities are highly favorable for tissue engineering and drug delivery, and these features are not able to be offered by monolithic fibers. In this review, we begin with an overview on design requirement of core–shell fibers, followed by the summary of recent preparation methods of core–shell fibers, with focus on electrospinning-based techniques and other newly discovered fabrication approaches. We then highlight the importance and roles of core–shell fibers in tissue engineering and drug delivery, accompanied by thorough discussion on controllable release strategies of the incorporated bioactive molecules from the fibers. Ultimately, we touch on core–shell fibers-related challenges and offer perspectives on their future direction towards clinical applications.

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